Myoelectric Computer Interface to Reduce Muscle Co-activation After Stroke

April 7, 2026 updated by: Marc Slutzky, Northwestern University
This study examines whether in-lab training with a myoelectric-computer interface (MyCI) can reduce abnormal muscle co-activation after stroke.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

35

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Illinois
      • Chicago, Illinois, United States, 60611
        • Northwestern University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Stroke survivors at least 6 months after stroke onset
  • Persistent moderate to severe arm impairment
  • Increased arm tone

Exclusion Criteria:

  • Substantial impairment of vision, memory, language or concentration
  • Botulinum toxin use in the affected arm
  • Concomitant participation in another research study on the arm

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 60-minute Isometric
60-min Isometric MyCI training: EMG-controlled game training for 60-minutes per session
Behavioral: 60-min isometric MyCI training
EMG-controlled in-lab training with arm restrained for 60 minutes per session
Experimental: 90-minute Isometric
90-min Isometric MyCI training: EMG-controlled game training for 90-minutes per session
Behavioral: 90-min isometric MyCI training
EMG-controlled in-lab training with arm restrained for 90 minutes per session
Experimental: 90-minute Movement
90-min movement MyCI training: EMG-controlled game training for 90-minutes per session
Behavioral: 90-min movement MyCI training
EMG-controlled in-lab training without restraint for 90 minutes per session

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Fugl-Meyer Assessment - Upper Extremity
Time Frame: 6 weeks
Scale 0-66, total score
6 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Fugl-Meyer Assessment - Upper Extremity
Time Frame: 10 weeks
Scale 0-66, total score
10 weeks
Wolf Motor Function Test
Time Frame: 6 and 10 weeks
Timed test
6 and 10 weeks
Motor Activity Log
Time Frame: 6 and 10 weeks
30-question test, total score
6 and 10 weeks

Other Outcome Measures

Outcome Measure
Time Frame
Modified Ashworth Scale
Time Frame: 6 and 10 weeks
6 and 10 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Northwestern University

Investigators

  • Principal Investigator: Marc Slutzky, MD, PhD, Northwestern University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 1, 2014

Primary Completion (Actual)

November 1, 2017

Study Completion (Actual)

November 1, 2017

Study Registration Dates

First Submitted

June 28, 2018

First Submitted That Met QC Criteria

July 5, 2018

First Posted (Actual)

July 9, 2018

Study Record Updates

Last Update Posted (Actual)

April 13, 2026

Last Update Submitted That Met QC Criteria

April 7, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • STU00042554

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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