Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction (oclusion)

Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction: a Randomized Controlled Trial

Introduction: studies on resistance training of low intensity associated with blood flow restriction in recent years, although there are still gaps that can be explored in relation to their physiological phenomena when associated with eccentric training. In this way, from there the exploration becomes relevant the investigation of eccentric training associated to an RFS. Objective: To analyze and compare the effects of a high intensity and low intensity intensive resistance training associated with an RFS (TREAI-RFS and TREBI-RFS) with a high intensity eccentric resistance training without RFS (TREAI) in knee extensors. Method: The study will consist of 45 male participants, allocated from a stratified randomization into three groups: TREAI (n = 15), TREAI-RFS (n = 15) and TREBI-RFS (n = 15). Participants underwent a training program with a minimum of 40% without RFS, 80% with RFS and 40% with CVS of CVIM, 3 times a week, and the outcomes of muscle strength, muscle structure, power test and Endothelial growth will be assessed one week before, the fourth week and one week after the end of the training program. In addition, clinical markers of perception and recovery effort are investigated before and after a session. The graph used is descriptive and descriptive, as it is used as a model of analysis of variance for the analysis of replications without a two-factor scheme, which provides detailed information on how the measures are repeated, neither. A whole statistical analysis can reach the level of significance of 5%.

Study Overview

• Status: Completed
• Conditions: Exercise
• Intervention / Treatment: Other: High intensity eccentric training; Other: High intensity eccentric training with BFR; Other: Low intensity eccentric training with BFR; Other: Low intensity eccentric training

• Study Type: Interventional
• Enrollment (Actual): 61
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • SP
    • Presidente Prudente, SP, Brazil, 55
      • Franciele Marques Vanderlei

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• male sex;
• healthy;
• aged between 18 and 35 years

Exclusion Criteria:

• smokers;
• alcoholics;
• use drugs that influenced cardiac autonomic activity;
• cardiovascular, metabolic or endocrine diseases.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: HIET (n = 15); High intensity eccentric training: A high intensity (80% isometric peak) eccentric training of the knee extensors in the isokinetic will be performed during 6 weeks, 3 times a week.	Other: High intensity eccentric training; High intensity eccentric training group with 80% of isometric peak torque.
Experimental: HIET-BFR (n= 15); High intensity eccentric training with blood flow restriction (BFR): A high intensity eccentric (80% isometric peak) training of the knee extensors in isokinetic will be performed, associated with a pressure cuff placed in the proximal thigh (40% of absolute occlusion pressure) for 6 weeks, 3 times a week.	Other: High intensity eccentric training with BFR; Eccentric high intensity training group with 80% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).
Experimental: LIET-BFR (n = 15); Low intensity eccentric training with blood flow restriction (BFR): A low intensity eccentric (40% isometric peak) training of the knee extensors in isokinetic will be performed associated with a pressure cuff placed in the proximal thigh (40% absolute occlusion pressure) for 6 weeks, 3 times a week.	Other: Low intensity eccentric training with BFR; Low intensity eccentric training group with 40% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).
Active Comparator: LIET (n= 15); Low intensity eccentric training: A low intensity (40% isometric peak) eccentric training of the knee extensors in the isokinetic will be performed during 6 weeks, 3 times a week.	Other: Low intensity eccentric training; Low intensity eccentric training group with 40% of isometric peak torque

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in muscle strength torque peaks at dinamometer isokinetic	The isometric, eccentric and concentric torque peaks will be measured with an isokinetic dynamometer in order to evaluate the adaptations of knee extensor force to eccentric training.	baseline, fourth week and one week after sixth week
Change in muscular structure with ultrasonography	Ultrasonographic imaging of the dominant lower limb will be captured to determine muscle thickness of the vastus lateralis (VL) and rectus femoris (RF) muscles.	baseline, fourth week and one week after sixth week.
Change in Vascular Endothelial Growth Factor (VEGF)	For the analysis of the concentration of endothelial growth factor (VEGF) will be collected 10 ml of blood sample. The plasma of this sample will be stored at -80 ° C for further analysis.	baseline, fourth week and one week after sixth week.
Change in muscle power test	The strength and muscle power tests will be performed on a vertical squat with a guided bar.	baseline, fourth week and one week after sixth week.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pain threshold	To assess the pain threshold, the pressure algometer will be applied at five specific locations on the quadriceps.	Assessed at baseline, 4th week, and 6th week.
Analog Visual Scale	The subjective evaluation of pain will be obtained through the Visual Analogue Scale (EVA), graded from 0 to 10, with zero being the total absence of pain and 10 the maximum level of pain supported by the participant.	Assessed at baseline, 4th week, and 6th week.
Perceived Effort Scale (Borg)	The degree of subjective exertion reported by the participants in relation to the lower limbs will be analyzed by Borg's scale of perception of effort of 6 to 20 points, 6 being "very easy" and 20 being "exhaustive."	Assessed at baseline, 4th week, and 6th week.
Recovery Perception Scale	The perception of recovery of the lower limb submitted to the eccentric exercise protocol will be evaluated by means of a 10-point Likert Scale, where 1 indicates "not recovered" and 10 "fully recovered".	Assessed at baseline, 4th week, and 6th week.

Collaborators and Investigators

• Sponsor: Paulista University
• Investigators: Principal Investigator: Franciele Marques Vanderlei, PhD, Universidade Estadual Paulista - FCT / UNESP

Study record dates

Study Major Dates

• Study Start (Actual): March 12, 2019
• Primary Completion (Actual): May 12, 2019
• Study Completion (Actual): December 31, 2020

Study Registration Dates

• First Submitted: June 21, 2018
• First Submitted That Met QC Criteria: July 17, 2018
• First Posted (Actual): July 26, 2018

Study Record Updates

• Last Update Posted (Actual): March 9, 2021
• Last Update Submitted That Met QC Criteria: March 8, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Keywords: Resistance Training; Eccentric Training
• Other Study ID Numbers: 680075683140

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No