China Cognition and Aging Study

China Cognition and Aging Study: a Multi-center, National-wide, Longitudinal Study in China

Sponsors

Lead Sponsor: Capital Medical University

Collaborator: Beijing Tiantan Hospital
Beijing Chao Yang Hospital
Fu Xing Hospital, Capital Medical University
Peking Union Medical College Hospital
Peking University First Hospital
Peking University Third Hospital
Chinese PLA General Hospital
China-Japan Friendship Hospital
Beijing Geriatric Hospital
The First Affiliated Hospital of Dalian Medical University
Fujian Medical University Union Hospital
Guangzhou Psychiatric Hospital
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
First Affiliated Hospital of Guangxi Medical University
The Affiliated Hospital Of Guizhou Medical University
Handan Central Hospital
Hebei General Hospital
First Hospital of Shijiazhuang City
Tangshan Worker's Hospital
Hunan Provincial People's Hospital
Kaifeng Central Hospital
People's Hospital of Zhengzhou University
Wuhan University Zhongnan Hospital
First Affiliated Hospital of Harbin Medical University
Tongji Hospital
People's Hospital Affiliated Hubei Medical University
The Third Xiangya Hospital of Central South University
Xiangya Hospital of Central South University
The First Hospital of Jilin University
China-Japan Union Hospital, Jilin University
Subei People's Hospital of Jiangsu
Nantong University Affiliated Hospital
Mineral General Hospital, Xuzhou
Jiangxi Provincial People's Hopital
Anshan Central Hospital
The Affiliated Zhongshan Hospital of Dalian University
First Hospital of China Medical University
Baotou Central Hospital
General Hospital of Ningxia Medical University
The People's Hospital of Ningxia
The Affiliated Hospital of Qingdao University
The 960th Hospital of PLA
Qilu Hospital of Shandong University
Qilu Hospital of Shandong University (Qingdao)
Shandong Provincial Hospital
Qingdao Municipal Hospital
The First Affiliated Hospital of Shanxi Medical University
Tang-Du Hospital
First Affiliated Hospital Xi'an Jiaotong University
Ruijin Hospital
RenJi Hospital
Shanghai Changzheng Hospital
Affiliated Hospital of North Sichuan Medical College
Tianjin Huanhu Hospital
Tianjin Medical University General Hospital
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region
Ningbo Medical Center Lihuili Hospital
First Affiliated Hospital of Wenzhou Medical University
First Affiliated Hospital of Zhejiang University
Shao Yifu Hospital of Zhejiang Medical University
Zhejiang Provincial People's Hospital
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
The Second Affiliated Hospital of Chongqing Medical University
The First Affiliated Hospital of Anhui Medical University
People's Hospital of Chongqing
Dongfang Hospital Beijing University of Chinese Medicine
Zigong First People's Hospital

Source Capital Medical University
Brief Summary

The aim of this study is to establish and perfect the China Cognition and Aging Study (China COAST) cohort, to clarify the epidemiology, influencing factors, genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of dementia and its subtypes in China. It is of great significance to establish a relatively comprehensive national database of cognitive disorders, improve the clinical diagnosis and treatment level of cognitive disorders, and formulate prevention and treatment strategies for dementia. The primary aims of China COAST are as follows: 1. To use the prospective cohort to establish a large database research platform, so as to provide comprehensive epidemiological data, clinical and neuropsychological evaluation data, biological samples, and laboratory tests and imaging data. 2. To update the prevalence and incidence rate of dementia and its subtypes every 2-3 years, and clarify the conversion pattern from normal elderly to MCI and from MCI to dementia. 3. To explore the known or unknown protective and risk factors of dementia and its major subtypes (AD, VaD, other dementia). 4. To discover new pathogenic genes and susceptible genes of dementia and its major subtypes (AD and VaD), as well as new mutation sites of known pathogenic genes. To study the genetic variation, mutation and polymorphism of PSEN1, PSEN2, APP and APOE genes in dementia patients, and to understand their distribution and roles in the pathogenesis. 5. To study the biomarkers (body fluid, genetics, imaging) with diagnostic value of MCI, AD (sporadic and familial) and VaD, to define their cut-off values, and to establish prediction models. 6. To study the diagnostic criteria of cognitive normal, MCI, dementia and their subtypes (clinical and molecular subtypes) in the cohort, and to make psychological assessment scales with high sensitivity and specificity, and in line with the characteristics of Chinese people. 7. To find potentially modifiable risk factors for dementia and to study the prevention and intervention effect of non-pharmacological treatment on APOE ε4 carriers, MCI and AD or other dementia patients,which included improvements in education, nutrition, health care, and lifestyle changes. This needs a long time follow-up. 8. To explore the relationship between dementia as well as its major subtype AD and cerebral and systemetic circulatory disorders (for example, mixed dmentia), as well as potential therapeutic strategies. 9. To carry out investigation and researches about dementia related education, improve the awareness of dementia, and strengthen the management of dementia.

Detailed Description

This study involved participants including Mild cognitive impairment (MCI) and its subtypes、Sporadic Alzheimer's disease (SAD)、 Familial Alzheimer's disease (FAD)、Vascular dementia (VaD)、Normal control in community population and hospital population. Research contents are as follow: 1. Through the collection of basic demographic information and clinical data from the multi-center cohort, we will calculate the prevalence and incidence rate of AD, VaD, other dementia (mixed dementia, FTD, DLB, PDD, alcohol dementia, hydrocephalus dementia, post-traumatic dementia, etc.), and update the numbers every 1-2 years. 2. To clarify the conversion pattern from normal elderly to MCI and from MCI to dementia. Through the collection and analysis of current medical history, past history, family history, living habits, drug use, physical examination and other information, we will explore the protective and risk factors of dementia and its main subtypes (AD, VaD, Other dementia), including age, gender, education level, rural/urban, marital status, parental dementia history, dietary habbit, blood pressure, drinking, smoking, diabetes, hyperlipidemia, cerebrovascular disease, heart disease, depression, hearing impairment, exercise habits (Tai chi, etc.), dementia specialist influence on patients, occupation, BMI, lifestyle changes, air pollution, head injury , social contact, low-income, and other unknown protective or risk factors. To investigate the role of ApoE gene, especially ApoEε4 in the disease onset and development, and to explore the non-pharmacological interventions For the study purpose we do follow-up every 2or 3 years. 3. By using exome sequencing, GWAS, WGS and other methods, we will search for new mutations of known pathogenic genes (APP, PSEN1, PSEN2) of AD in China, find new pathogenic genes and susceptible genes of dementia and its main subtypes (AD and VaD), and understand their distribution. We will explore the independent and combined effect of susceptibility gene variation on the risk of illness in Chinese AD population, and to obtain the key mutation sites that have a clear relationship with the incidence of AD. We will do regular follow up visits for the FAD members with new mutations of pathogenic genes, and clarify the important role of new mutations of pathogenic genes during the onset and progression of AD. 4. We will collect the biofluids (blood, cerebrospinal fluid, urine, etc.) and 18F-FDG / 11C-PIB PET/MR multimodal imaging data from people with normal cognition, MCI, AD (sporadic and familial) and VaD, and conduct regular follow up. Discover and verify the SAD related susceptible gene and FAD related pathogenic gene mutation. Through analyzing the imaging data (such as MRI brain regional volume, 18F-FDG PET and cortical Aβ load), cerebrospinal fluid and plasma markers (such as Aβ, T-tau and P-tau) and clinical features (such as psychiatric symptoms and age of onset), we will develop gene chip with high sensitivity and high specificity for early screening of dementia; develop diagnostic kits for biofluid markers (blood and cerebrospinal fluid); determine imaging cut-off values at all stages of dementia in Chinese people. We will do correlation analysis to establish early diagnosis and risk prediction model for dementia, and verify the newly developed instruments that can detect the peripheral markers of dementia patients and predict the disease progression in national large sample. 5. Through the unified and standardized neuropsychological scales, including MMSE, MoCA, CDR, NPI, ADL, etc, we will conduct investigation to subjects in baseline and follow-up period, and analyze the changes of cognitive function, ability of daily life and mental behavior symptoms in different cognitive disorders. According to the social, cultural and material changes in China in recent years, we will develop psychological assessment scales with high sensitivity and specificity, and in line with the characteristics of Chinese people. Meanwhile, on the basis of the international diagnostic standards of various subtypes of dementia, combined with the etiology, clinical manifestations, scale classification, imaging characteristics, biofluid examination, etc., we will study the novel typing method and diagnostic standards of cognitive normal, MCI, dementia and its subtypes (clinical and molecular subtypes) in Chinese population. 6. Through designing randomized controlled trials, we will study the systematic and effective NPT intervention program, including lifestyle (diet and sleep habits, smoking, drinking and social networking), health products, exercise habits, cognitive training, risk factor control, etc. We will explore the quantitative and objective evaluation criteria of NPT in AD and dementia, clarify its prevention and control efficacy on APOE ε4 carriers, MCI and dementia patients, and potential neurobiological mechanism. At the same time, we will carry out dementia related education in the community, improve the public knowledge, attention and awareness of dementia, so that patients can get early detection, early diagnosis and early intervention. 7. To explore the relationship between dementia as well as its major subtype AD and cerebral circulatory disorders (cerebral ischemic and hemorrhage diseases, cerebral arteriosclerosis and stenosis, cerebral venous diseases, etc.), especially clarify the relationship between chronic cerebral ischemia and AD, as well as its effect on AD onset, and whether or not it's risk factor for AD. Whether the therapeutic strategies for cerebral circulatory disorders should be included in the treatment of AD.

Overall Status Recruiting
Start Date 2007-01-10
Completion Date 2038-01-01
Primary Completion Date 2038-01-01
Study Type Observational [Patient Registry]
Primary Outcome
Measure Time Frame
The prevalence of MCI and AD measured using a population-based cross-sectional survey with a multistage cluster sampling design an average of 2 years
The conversion rate of normal to MCI to AD in Chinese an average of 2 years
The biomarkers for normal (pre-MCI), MCI and AD diagnosis an average of 2 years
The risk factors (genetic and environmental factors) for MCI, AD and VCI at genomic and expression levels an average of 2 years
The effective non-pharmacologic treatment(NPT) intervention an average of 2 years
Enrollment 100000
Condition
Eligibility

Sampling Method:

Non-Probability Sample

Criteria:

Community population: age ≥ 55 years, male or female, with consent to participant the study. Hospital population: subjects are all over 18 years old. Through clinical evaluation, neuropsychological test, imaging examination, blood and cerebrospinal fluid examination, etc, we will comprehensively evaluate the cognitive function and various test measures. (1) MCI and its subtypes Inclusion criteria: 1. Diagnosis according to 2004 Peterson's MCI criteria. 2. CDR = 0.5. 3. Memory loss is prominent, and may also be with other cognitive domain dysfunction. 4. Insidious onset, slow progress. 5. Not reaching the level of dementia. Exclusion criteria: 1. With history of stroke and a neurological focal sign, the imaging findings are consistent with cerebral small vessal disease (Fazekas score ≥ 2 points). 2. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 3. Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.). 4. Mental and neurodevelopmental retardation. 5. Contraindications to MRI. 6. Suffering from a disease that cannot be combined with cognitive examination. 7. Refuse to draw blood. 8. Refuse to sign the informed consent at baseline (2) Sporadic Alzheimer's disease (SAD) Inclusion criteria: 1. Dementia is diagnosed according to the criteria described by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-R). The diagnosis of AD is made using the National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) or National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria. 2. Subjects and their informed persons can complete relevant and follow- up examinations. 3. Subjects or their authorized legal guardians sign the informed consent. Exclusion criteria: 1. With a family history of dementia. 2. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 3. Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.). 4. Mental and neurodevelopmental retardation. 5. Contraindications to MRI. 6. Suffering from a disease that cannot be combined with cognitive examination. 7. Refuse to draw blood. 8. Refuse to sign the informed consent at baseline (3) Familial Alzheimer's disease (FAD) Inclusion criteria: 1. Written informed consent obtained from participant or legal guardian prior to any study-related procedures. 2. Members in FAD pedigree (FAD is defined as at least two first- degree relatives suffer from AD). 3. Aged 18 (inclusive) or older. 4. At least two persons who can provide reliable information for the study. Note: Dementia is diagnosed according to the criteria described by DSM-IV-R. The diagnosis of AD is made using NINCDS-ADRDA or NIA-AA criteria. A diagnosis of MCI is assigned according to Petersen criteria. Exclusion criteria: 1. Dementia caused by other factors such as depression, other psychiatric illnesses, thyroid dysfunction, encephalitis, multiple sclerosis, brain trauma, brain tumor, syphilis, acquired immunodeficiency syndrome (AIDS), Creutzfeldt-Jakob disease and other types of dementias such as vascular dementia (VaD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD). 2. MRI and laboratory tests do not support or rule out a diagnosis of AD. 3. Severe circulatory, respiratory, urinary, digestive, hematopoietic diseases (such as unstable angina, uncontrollable asthma, active gastric bleeding) and cancer. 4. Participant has severe psychiatric illness or severe dementia that would interfere in completing initial and follow-up clinical assessments. 5. With history of alcohol or drug abuse. 6. Pregnant or lactating women. 7. No reliable insiders. 8. Refuse to sign the informed consent at baseline. (4) Vascular dementia (VaD) Inclusion criteria: Diagnosis for probable VaD according to NINDS-AIREN diagnostic criteria. MRI inclusion criteria: All patients who meet clinical inclusion criteria should accept MRI scans which include an assessment of hippocampal volume. 1. multiple (≥3) supratentorial subcortical small infarcts (3-20 mm in diameter) with or without any degree of white matter lesion (WML); or moderate to severe WML (Fazekas score ≥ 2), with or without small infarction; or ≥ 1 subcortical small infarct in key regions, such as caudate nucleus, globus pallidus, or thalamus. 2. no cortical and watershed infarction, hemorrhage, hydrocephalus, or WML with specific causes (such as multiple sclerosis). 3. no hippocampus or entorhinal cortex atrophy (MTA score = 0 point). Exclusion criteria: 1. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 2. Other systemic diseases that can cause cognitive impairment (such as liver insufficiency, renal insufficiency, thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.). 3. With a history of mental illness or those with congenital mental retardation. 4. Suffering from a disease that cannot be combined with a cognitive examination. 5. Contraindications to MRI. 6. Refuse to draw blood. 7. Refuse to sign informed consent. (5) Normal control Inclusion criteria: 1. Aged 18 (inclusive) or above. 2. Normal MMSE and MoCA evaluations. MMSE>19 points for illiteracy, >24 points for those educated less than 7 years, >27 points for those educated equal to or more than 7 years. MoCA>13 points for illiteracy, >19 points for those educated less than 7 years, >24 points for those educated equal to or more than 7 years. Exclusion criteria: 1. Subjects with abnormal MMSE or MoCA scores. 2. Subjects with a history of cerebral infarction, traumatic brain injury or related manifestations in MRI. 3. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 4. Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.). 5. Mental and neurodevelopmental retardation. 6. Suffering from a disease that cannot be combined with a cognitive examination. 7. Contraindications to MRI. 8. Refuse to draw blood. 9. Refuse to sign the informed consent at baseline.

Gender:

All

Minimum Age:

18 Years

Maximum Age:

N/A

Healthy Volunteers:

Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Jianping Jia, Doctor Study Chair Xuanwu Hospital of Capital Medical University
Overall Contact

Last Name: Jianping Jia, Doctor

Phone Ext.: 010-83108650

Email: [email protected]

Location
Facility: Status: Contact:
The First Affiliated Hospital of Anhui Medical University | Hefei, Anhui, China Recruiting Yanghua Tian, Doctor [email protected]
Beijing Geriatric Hospital | Changping, Beijing, China Recruiting Jihui Lv [email protected]
Beijing Chao Yang Hospital | Chaoyang, Beijing, China Recruiting Yue Wang, Doctor [email protected]
China-Japan Friendship Hospital | Chaoyang, Beijing, China Recruiting Dantao Peng [email protected]
Dongfang Hospital Affiliated to Beijing University of Chinese Medicine | Fengtai, Beijing, China Recruiting Lanxiang Jin, Doctor [email protected]
Chinese PLA General Hospital | Haidian, Beijing, China Recruiting Jianjun Jia, Doctor [email protected]
Fu Xing Hospital, Capital Medical University | Haidian, Beijing, China Recruiting Fang Li, Doctor [email protected]
Peking University Third Hospital | Haidian, Beijing, China Recruiting Weizhong Xiao [email protected]
Peking Union Medical College Hospital | Xicheng, Beijing, China Recruiting Jing Gao, Doctor [email protected]
Peking University First Hospital | Xicheng, Beijing, China Recruiting Zhirong Jia [email protected]
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | Yuzhong, Chongqing, China Recruiting Yanjiang Wang
The Second Affiliated Hospital of Chongqing Medical University | Yuzhong, Chongqing, China Recruiting Yangmei Chen [email protected]
Fujian Medical University Union Hospital | Fujian, Guangdong, China Recruiting Qinyong Ye [email protected]
Guangzhou Psychiatric Hospital | Guangzhou, Guangdong, China Recruiting Mouni Tang, Doctor [email protected]
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Zhongshan, Guangdong, China Recruiting Jun Liu, Doctor [email protected]
First Affiliated Hospital of Guangxi Medical University | Nanning, Guangxi, China Recruiting Shengliang Liang [email protected]
The Affiliated Hospital Of Guizhou Medical University | Guiyang, Guizhou, China Recruiting Lan Chu, Doctor [email protected]
Handan Central Hospital | Handan, Hebei, China Recruiting Minchen Kan, Doctor [email protected]
First Hospital of Shijiazhuang City | Shijiazhuang, Hebei, China Recruiting Huiying Zhao [email protected]
Tangshan Worker's Hospital | Tangshan, Hebei, China Recruiting Yongqiu Li, Doctor [email protected]
Hebei General Hospital | Zhijiazhuang, Hebei, China Recruiting Peiyuan Lv, Doctor [email protected]
First Affiliated Hospital of Harbin Medical University | Haerbin, Heilongjiang, China Recruiting Shurong Duan, Doctor [email protected]
Kaifeng Central Hospital | Kaifeng, Henan, China Recruiting Huanrong Yu, Doctor [email protected]
Henan Provincial People's Hospital | Zhengzhou, Henan, China Recruiting Jiewen Zhang, Doctor [email protected]
People's Hospital of Zhengzhou | Zhengzhou, Henan, China Recruiting Shuling Zhang, Doctor
People's Hospital Affiliated Hubei Medical University | Wuhan, Hubei, China Recruiting Jianjun Zhang, Doctor [email protected]
Tongji Hospital | Wuhan, Hubei, China Recruiting Min Zhang [email protected]
The Third Xiangya Hospital of Central South University | Wuhan, Hunan, China Recruiting Lu Shen [email protected]
Wuhan University Zhongnan Hospital | Wuhan, Hunan, China Recruiting Hanxing Liu [email protected]
Xiangya Hospital of Central South University | Wuhan, Hunan, China Recruiting Qiuyun Tu, Doctor [email protected]
Nantong University Affiliated Hospital | Nantong, Jiangsu, China Recruiting Maohong Cao, Doctor [email protected]
Subei People's Hospital of Jiangsu | Subei, Jiangsu, China Recruiting Jun Xu, Doctor [email protected]
Mineral General Hospital, Xuzhou | Xuzhou, Jiangsu, China Recruiting Liangqun Rong, Doctor [email protected]
Jiangxi Provincial People's Hospital | Nanchang, Jiangxi, China Recruiting Kunnan Zhang, Doctor [email protected]
China-Japan friendship Hospital of Jilin university | Changchun, Jilin, China Recruiting Qin Zhao, Doctor [email protected]
The First Hospital of Jilin University | Changchun, Jilin, China Recruiting Li Sun, Doctor [email protected]
Changda Hospital, Anshan | Anshan, Liaoning, China Recruiting Xiu Han, Doctor [email protected]
Affiliated Zhongshan hospital of Dalian university | Dalian, Liaoning, China Recruiting Qiang Ma, Doctor [email protected]
The First Affiliated Hospital of Dalian Medical University | Dalian, Liaoning, China Recruiting Cui Wang, Doctor [email protected]
First Hospital of China Medical University | Shenyang, Liaoning, China Recruiting Yunpeng Cao, Doctor [email protected]
Baotou Central Hospital | Baotou, Nei Monggol, China Recruiting Furu Liang, Doctor [email protected]
General Hospital of Ningxia Medical University | Yinchuan, Ningxia, China Recruiting Qin Zhang, Doctor [email protected]
The People's Hospital of Ningxia | Yinchuan, Ningxia, China Recruiting Yongying Gao, Doctor [email protected]
Qilu Hospital of Shandong University | Jinan, Shandong, China Recruiting Peiyan Shan, Doctor [email protected]
Shandong Provincial Hospital | Jining, Shandong, China Recruiting Yifeng Du, Doctor [email protected]
Qilu Hospital of Shandong University (Qingdao) | Qingdao, Shandong, China Recruiting Bin Liang, Doctor [email protected]
QingDao Municipal Hospital | Qingdao, Shandong, China Recruiting Lan Tan, Doctor [email protected]
The Affiliated Hospital of Qingdao University | Qingdao, Shandong, China Recruiting Jinping Sun, Doctor [email protected]
The 88th Hospital of PLA | Tai'an, Shandong, China Recruiting Jintao Zhang, Doctor [email protected]
Shanghai Changzheng Hospital | Huangpu, Shanghai, China Recruiting Jianhua Zhuang, Doctor [email protected]
Ruijin Hospital | Luwan, Shanghai, China Recruiting Gang Wang, Doctor [email protected]
RenJi Hospital | Putong, Shanghai, China Recruiting Qun Xu, Doctor xuqun628[email protected]
The First Affiliated Hospital of Shanxi Medical University | Taiyuan, Shanxi, China Recruiting Yuling Tian, Doctor [email protected]
First Affiliated Hospital Xi'an Jiaotong University | Xi'an, Shanxi, China Recruiting Qiumin Qu, Doctor [email protected]
Tang-Du Hospital | Xi'an, Shanxi, China Recruiting Wei Zhang, Doctor [email protected]
Affiliated Hospital of North Sichuan Medical College | Nanchong, Sichuan, China Recruiting Ying Ma, Doctor [email protected]
Zigong First People's Hospital | Zigong, Sichuan, China Recruiting Xiaoya Xu, Doctor [email protected]
Tianjin Medical University General Hospital | Heping, Tianjin, China Recruiting Nan Zhang, Doctor [email protected]
Tianjin Huanhu Hospital | Jinnan, Tianjin, China Recruiting Yuying Zhou, Doctor [email protected]
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region | Urumqi, Xinjiang, China Recruiting Xinling Meng [email protected]
First Affiliated Hospital of Zhejiang University | Hangzhou, Zhejiang, China Recruiting Benyan Luo, Doctor [email protected]
Shao Yifu Hospital of Zhejiang Medical University | Hangzhou, Zhejiang, China Recruiting Peilin Lu, Doctor [email protected]
Zhejiang Provincial People's Hospital | Hangzhou, Zhejiang, China Recruiting Enyan Yu [email protected]
Ningbo City Medical Treatment Center Lihuili Hospital | Ningbo, Zhejiang, China Recruiting Guomin Xie, Doctor [email protected]
First Affiliated Hospital of Wenzhou Medical Univeristy | Wenzhou, Zhejiang, China Recruiting Zhen Wang [email protected]
Location Countries

China

Verification Date

2021-04-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Capital Medical University

Investigator Full Name: Jianping Jia

Investigator Title: Chief Director

Has Expanded Access No
Condition Browse
Arm Group

Label: Mild cognitive impairment (MCI) and its subtypes

Description: MCI cohort consists of mild cognitive impairment subjects with memory loss as predominant symptom, including amnestic mild cognitive impairment and vascular cognitive impairment no dementia, which recruit from community population and hospital population.

Label: Sporadic Alzheimer's disease (SAD)

Description: SAD cohort consists of mild to moderate sporadic Alzheimer's disease subjects, which recruit from community population and hospital population.

Label: Familial Alzheimer's disease (FAD)

Description: FAD cohort consists of familial Alzheimer disease subjects with known or unknown mutations, which recruit from community population and hospital population.

Label: Vascular dementia(VaD)

Description: VaD cohort consists of cognitive impairment subjects caused by cerebral vessel disease, including vascular dementia and mixes dementia, which recruit from community population and hospital population.

Label: Normal control

Description: Normal control cohort consists of cognitive normal subjects with ApoE ε4 positive or negative, which recruit from community population and hospital population.

Label: Non-Alzheimer degenerative dementia

Description: Frontotemporal dementia (FTD); or Parkinson's disease dementia (PDD); or dementia with Lewy bodies (DLB); or corticobasal degeneration (CBD); or dementia not otherwise specified.

Acronym COAST
Patient Data Undecided
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

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