Analgesia in Total Hip Arthroplasty by Quadratus Lumborum Block (ATHAQLuB)

Comparison of the Clinical Effectiveness of the Quadratus Lumborum Block and Femoral Block in the Analgesia of Total Posterior Hip Arthroplasty

Patients are painful after total hip arthroplasty. These patients have significant co-morbidities. Analgesics cause significant side effects in this population. Locoregional analgesia is therefore an effective means of reducing the consumption of opioids in this surgery.

The "gold standard" of locoregional analgesia after Total Hip Arthroplasty is the femoral block. However, a new technique has recently been described: the Quadratus Lumborum Block.

The comparison of these two techniques is lacking in the literature. The comparison of the Quadratus Lumborum Block to the femoral block in Total Hip arthroplasty is important in the analgesic strategy of patients undergoing this surgery.

Study Overview

• Status: Unknown
• Conditions: Total Hip Replacement Surgery
• Intervention / Treatment: Procedure: Quadratus Lumborum Block; Procedure: femoral block

Detailed Description

The aim of this study is to compare the clinical efficacy of two regional locoregional analgesia strategies in total hip replacement surgery: the ultrasound-guided Quadratus Lumborum Block and the ultrasound-guided femoral block.

This is a double-blind, randomized study in prospective inclusion with a superiority test. Two groups of patients will be compared: a group of patients with a quadratus lumborum block and a group of patients with a femoral block.

Management (quadratus lumborum block or femoral block) will be randomized. The randomization will be stratified on the type of anesthesia (spinal anesthesia and general anesthesia). Randomization will be done on the day of surgery to determine the patient's treatment group. The surgical procedure will not be modified by the participation of the patent in the study.

Patients who would benefit from total hip replacement surgery in the Reims University Hospital and who agreed to participate in the study were included.

• Study Type: Interventional
• Enrollment (Anticipated): 170
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Olivier FERNANDES; Phone Number: 03 10 73 61 68; Email: 0fernandes@chu-reims.fr
• Study Contact Backup: Name: Armelle DE BAENE; Phone Number: 03 10 73 66 70; Email: adebaene@chu-reims.fr

Study Locations

• France
  • Reims, France
    • Recruiting
    • Damien JOLLY
    • Contact: Olivier FERNANDES; Phone Number: 03 10 73 61 68; Email: ofernandes@chu-reims.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 95 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients eligible for total hip replacement surgery in Reims University Hospital
• Patients agreeing to participate in the research and having signed informed consent
• between 18 yo and 95 yo
• Patients affiliated to a social security system

Exclusion Criteria:

• Patients with allergy to local anesthetics
• Patients with neuropathy
• Patients with an ASA score of 4
• Patients undergoing revision surgery for total hip arthroplasty
• Patients receiving anterior hip total hip replacement surgery
• Patients with a contraindication to the realization of the quadratus lumborum block, femoral block or spinal anesthesia (clinical coagulopathy, infection at the point of puncture ...)
• Patients refusing the proposed techniques

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Quadratus Lumborum Block arm	Procedure: Quadratus Lumborum Block; Quadratus Lumborum Block with echography
Active Comparator: Femoral block arm	Procedure: femoral block; femoral block with echography

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
morphine consumption	Morphine consumption during the 24 hours postoperative	24 hours

Collaborators and Investigators

• Sponsor: CHU de Reims

Study record dates

Study Major Dates

• Study Start (Actual): October 8, 2018
• Primary Completion (Anticipated): October 8, 2020
• Study Completion (Anticipated): April 8, 2021

Study Registration Dates

• First Submitted: September 10, 2018
• First Submitted That Met QC Criteria: September 10, 2018
• First Posted (Actual): September 11, 2018

Study Record Updates

• Last Update Posted (Actual): December 11, 2018
• Last Update Submitted That Met QC Criteria: December 10, 2018
• Last Verified: September 1, 2018

More Information

Terms related to this study

• Keywords: post operative pain; quadratus lumborum block; femoral block; Total hip replacement surgery
• Other Study ID Numbers: PO18122

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No