- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03695458
Local and Systemic Effects of Photobiomodulation Therapy on Muscle Performance and Recovery Post-exercise.
November 28, 2019 updated by: Ernesto Cesar Pinto Leal Junior, University of Nove de Julho
Recent studies with photobiomodulation therapy have shown positive results in delaying skeletal muscle fatigue and improving performance through levels of biochemical markers and variables related to exercise when this therapy was applied before exercise.
Some studies suggest that photobiomodulation therapy has systemic effects, but it is not known whether therapy exerts any systemic effects on human skeletal muscle.
With this factor in mind, this research aims to verify the local and systemic effects of phototherapy on muscle performance and recovery after exercise in healthy male participants.
This research consists in a randomized, triple-blinded, placebo-controlled trial, with participation of 30 healthy subjects.
Will be analyzed parameters related to exercise performance (peak torque in the maximum voluntary contraction test- MVC), delayed onset muscle soreness (DOMS) by visual analogue scale (VAS), and biochemical marker of muscle damage (CK) and blood Lactate (BL).
The analysis will be performed before exercise protocol (baseline), after 1 minute of the exercise, and 1, 24, 48 and 72 hours after the end of exercise protocol
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
A total of 30 healthy male non-athletes, between 18-35 years, will be randomly divided into 3 experimental groups, named "Placebo (Control)", "Local", "Systemic", according to the lower limb who will receive photobiomodulation therapy.
Firstly, a blood collection will be performed by a nurse with sterile and disposable materials for posterior analysis of creatine kinase (CK) and Blood Lactate (BL).
Delayed onset muscle soreness (DOMS) will be assessed with the Visual Analogue Scale (VAS) using a 10 cm line.
Participants will be instructed to mark the line where their pain best fits at that time (0=no pain, 10=worst pain).Then, the maximum voluntary contraction test (MVC) will be performed, which will consist in performing 3 times of 5-sec isometric contractions of the non-dominant knee extensors in the isokinetic dynamometer device.
During the execution of the MVC, the participants will be verbally encouraged to exert the greatest force at that moment.
Photobiomodulation therapy will be applied 2 minutes after the MVC test in six points of non-dominant anterior thigh muscle.
After irradiation, participants will perform the protocol of eccentric contractions.
This protocol will be performed to induce muscle fatigue by resisting the movement of knee flexion in 5 series of 15 repetitions with 30 seconds -intervals (eccentric contractions).
Assessments (blood collection, VAS and MVC) will be performed before warm-up (baseline), 1 minute after exercise protocol and 1, 24, 48 and 72 hours after eccentric exercise protocol.
Study Type
Interventional
Enrollment (Actual)
30
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
SP
-
São Paulo, SP, Brazil, 01504-001
- Universidade Nove de Julho
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 35 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Healthy individuals,
- Non-athletes
- Those who practice physical activity at maximal of once a week
- Between 18 and 35 years old,
- Male
- No history of musculoskeletal injury in the hip or knee previous two months of the study.
- Not be taking pharmacological agents and / or nutritional supplements, and should have frequency of 100% in all days of data collection.
Exclusion Criteria:
- Individuals who present musculoskeletal injury during the study
- Chronic joint disease in the non-dominant lower limb
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo-Control
Photobiomodulation Therapy with the placebo program will be applied in both legs.
|
The Photobiomodulation Therapy will be applied 3 minutes after MVC test in 6 points of the quadriceps muscle (2 points in vastus lateralis, 2 in rectus femoris and 2 in vastus medialis).
Other Names:
|
Active Comparator: irradiation effect Local
Photobiomodulation Therapy with the active irradiation will be applied on the exercised leg and Photobiomodulation Therapy with the placebo program will be applied on the non-exercised leg.
|
The Photobiomodulation Therapy will be applied 3 minutes after MVC test in 6 points of the quadriceps muscle (2 points in vastus lateralis, 2 in rectus femoris and 2 in vastus medialis).
Other Names:
|
Active Comparator: irradiation effect Systemic
Photobiomodulation Therapy with the active program will be applied on non-exercised leg and Photobiomodulation Therapy with the placebo program will be applied on the exercised leg.
|
The Photobiomodulation Therapy will be applied 3 minutes after MVC test in 6 points of the quadriceps muscle (2 points in vastus lateralis, 2 in rectus femoris and 2 in vastus medialis).
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Maximum Voluntary Contraction
Time Frame: baseline
|
An isokinetic dynamometer (System 4, Biodex®, USA) will be used to assess muscle function and also for exercise protocol.
Immediately after warm-up, volunteers will perform the maximum voluntary contraction test (MVC).
Volunteers will be placed on the isokinetic dynamometer seated with a 100° angle between trunk and hip, and the non-dominant leg will be positioned to 60° knee flexion (0° corresponds to the total knee extension) and attached to the seat of the dynamometer through a belt.
Volunteers will also be attached to the dynamometer seat through two straps on their trunk.
MVC test consists of three isometric contractions of non-dominant lower limb knee extensors with a duration of 5 seconds and 30-second intervals between contractions, the highest torque value obtained at the three contractions (peak torque) will be used for statistical analysis.
|
baseline
|
Maximum Voluntary Contraction
Time Frame: 1 minute after the protocol of eccentric contractions
|
An isokinetic dynamometer (System 4, Biodex®, USA) will be used to assess muscle function and also for exercise protocol.
Immediately after warm-up, volunteers will perform the maximum voluntary contraction test (MVC).
Volunteers will be placed on the isokinetic dynamometer seated with a 100° angle between trunk and hip, and the non-dominant leg will be positioned to 60° knee flexion (0° corresponds to the total knee extension) and attached to the seat of the dynamometer through a belt.
Volunteers will also be attached to the dynamometer seat through two straps on their trunk.
MVC test consists of three isometric contractions of non-dominant lower limb knee extensors with a duration of 5 seconds and 30-second intervals between contractions, the highest torque value obtained at the three contractions (peak torque) will be used for statistical analysis.
|
1 minute after the protocol of eccentric contractions
|
Maximum Voluntary Contraction
Time Frame: 1 hour after the protocol of eccentric contractions
|
An isokinetic dynamometer (System 4, Biodex®, USA) will be used to assess muscle function and also for exercise protocol.
Immediately after warm-up, volunteers will perform the maximum voluntary contraction test (MVC).
Volunteers will be placed on the isokinetic dynamometer seated with a 100° angle between trunk and hip, and the non-dominant leg will be positioned to 60° knee flexion (0° corresponds to the total knee extension) and attached to the seat of the dynamometer through a belt.
Volunteers will also be attached to the dynamometer seat through two straps on their trunk.
MVC test consists of three isometric contractions of non-dominant lower limb knee extensors with a duration of 5 seconds and 30-second intervals between contractions, the highest torque value obtained at the three contractions (peak torque) will be used for statistical analysis.
|
1 hour after the protocol of eccentric contractions
|
Maximum Voluntary Contraction
Time Frame: 24 hours after the protocol of eccentric contractions
|
An isokinetic dynamometer (System 4, Biodex®, USA) will be used to assess muscle function and also for exercise protocol.
Immediately after warm-up, volunteers will perform the maximum voluntary contraction test (MVC).
Volunteers will be placed on the isokinetic dynamometer seated with a 100° angle between trunk and hip, and the non-dominant leg will be positioned to 60° knee flexion (0° corresponds to the total knee extension) and attached to the seat of the dynamometer through a belt.
Volunteers will also be attached to the dynamometer seat through two straps on their trunk.
MVC test consists of three isometric contractions of non-dominant lower limb knee extensors with a duration of 5 seconds and 30-second intervals between contractions, the highest torque value obtained at the three contractions (peak torque) will be used for statistical analysis.
|
24 hours after the protocol of eccentric contractions
|
Maximum Voluntary Contraction
Time Frame: 48 hours after the protocol of eccentric contractions
|
An isokinetic dynamometer (System 4, Biodex®, USA) will be used to assess muscle function and also for exercise protocol.
Immediately after warm-up, volunteers will perform the maximum voluntary contraction test (MVC).
Volunteers will be placed on the isokinetic dynamometer seated with a 100° angle between trunk and hip, and the non-dominant leg will be positioned to 60° knee flexion (0° corresponds to the total knee extension) and attached to the seat of the dynamometer through a belt.
Volunteers will also be attached to the dynamometer seat through two straps on their trunk.
MVC test consists of three isometric contractions of non-dominant lower limb knee extensors with a duration of 5 seconds and 30-second intervals between contractions, the highest torque value obtained at the three contractions (peak torque) will be used for statistical analysis.
|
48 hours after the protocol of eccentric contractions
|
Maximum Voluntary Contraction
Time Frame: 72 hours after the protocol of eccentric contractions
|
An isokinetic dynamometer (System 4, Biodex®, USA) will be used to assess muscle function and also for exercise protocol.
Immediately after warm-up, volunteers will perform the maximum voluntary contraction test (MVC).
Volunteers will be placed on the isokinetic dynamometer seated with a 100° angle between trunk and hip, and the non-dominant leg will be positioned to 60° knee flexion (0° corresponds to the total knee extension) and attached to the seat of the dynamometer through a belt.
Volunteers will also be attached to the dynamometer seat through two straps on their trunk.
MVC test consists of three isometric contractions of non-dominant lower limb knee extensors with a duration of 5 seconds and 30-second intervals between contractions, the highest torque value obtained at the three contractions (peak torque) will be used for statistical analysis.
|
72 hours after the protocol of eccentric contractions
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
enzymatic activity of creatine kinase (CK)
Time Frame: baseline
|
wil be analysis of the enzymatic activity of CK as an indirect marker of muscle damage, the initial absorbance will be read through the spectrophotometry test, use of specific reagent kits commercial manufactured (Labtest®, São Paulo - Brazil). 5 ml Blood samples, via antecubital vein puncture, will be collected in tubes by a nurse.
The samples, it will be centrifuged at 3000 rpm for 20 minutes.
The supernatant (serum) will then be pipetted and stored in tubes (Eppendorf ®) at -80°C for further analysis of the enzymatic activity of creatine kinase (CK).
|
baseline
|
enzymatic activity of creatine kinase (CK)
Time Frame: 1 minute after the protocol of eccentric contractions
|
wil be analysis of the enzymatic activity of CK as an indirect marker of muscle damage, the initial absorbance will be read through the spectrophotometry test, use of specific reagent kits commercial manufactured (Labtest®, São Paulo - Brazil). 5 ml Blood samples, via antecubital vein puncture, will be collected in tubes by a nurse.
The samples, it will be centrifuged at 3000 rpm for 20 minutes.
The supernatant (serum) will then be pipetted and stored in tubes (Eppendorf ®) at -80°C for further analysis of the enzymatic activity of creatine kinase (CK).
|
1 minute after the protocol of eccentric contractions
|
enzymatic activity of creatine kinase (CK)
Time Frame: 1 hour after the protocol of eccentric contractions
|
wil be analysis of the enzymatic activity of CK as an indirect marker of muscle damage, the initial absorbance will be read through the spectrophotometry test, use of specific reagent kits commercial manufactured (Labtest®, São Paulo - Brazil). 5 ml Blood samples, via antecubital vein puncture, will be collected in tubes by a nurse.
The samples, it will be centrifuged at 3000 rpm for 20 minutes.
The supernatant (serum) will then be pipetted and stored in tubes (Eppendorf ®) at -80°C for further analysis of the enzymatic activity of creatine kinase (CK).
|
1 hour after the protocol of eccentric contractions
|
enzymatic activity of creatine kinase (CK)
Time Frame: 24 hours after the protocol of eccentric contractions
|
wil be analysis of the enzymatic activity of CK as an indirect marker of muscle damage, the initial absorbance will be read through the spectrophotometry test, use of specific reagent kits commercial manufactured (Labtest®, São Paulo - Brazil). 5 ml Blood samples, via antecubital vein puncture, will be collected in tubes by a nurse.
The samples, it will be centrifuged at 3000 rpm for 20 minutes.
The supernatant (serum) will then be pipetted and stored in tubes (Eppendorf ®) at -80°C for further analysis of the enzymatic activity of creatine kinase (CK).
|
24 hours after the protocol of eccentric contractions
|
enzymatic activity of creatine kinase (CK)
Time Frame: 48 hours after the protocol of eccentric contractions
|
wil be analysis of the enzymatic activity of CK as an indirect marker of muscle damage, the initial absorbance will be read through the spectrophotometry test, use of specific reagent kits commercial manufactured (Labtest®, São Paulo - Brazil). 5 ml Blood samples, via antecubital vein puncture, will be collected in tubes by a nurse.
The samples, it will be centrifuged at 3000 rpm for 20 minutes.
The supernatant (serum) will then be pipetted and stored in tubes (Eppendorf ®) at -80°C for further analysis of the enzymatic activity of creatine kinase (CK).
|
48 hours after the protocol of eccentric contractions
|
enzymatic activity of creatine kinase (CK)
Time Frame: 72 hours after the protocol of eccentric contractions
|
wil be analysis of the enzymatic activity of CK as an indirect marker of muscle damage, the initial absorbance will be read through the spectrophotometry test, use of specific reagent kits commercial manufactured (Labtest®, São Paulo - Brazil). 5 ml Blood samples, via antecubital vein puncture, will be collected in tubes by a nurse.
The samples, it will be centrifuged at 3000 rpm for 20 minutes.
The supernatant (serum) will then be pipetted and stored in tubes (Eppendorf ®) at -80°C for further analysis of the enzymatic activity of creatine kinase (CK).
|
72 hours after the protocol of eccentric contractions
|
Blood Lactate
Time Frame: baseline
|
For analysis of the amount of blood lactate as an indirect marker of fatigue, a drop of blood will be collected from the first finger on the Bm-lactate strip and read through the Accutrend Plus COBAS® Monitor.
|
baseline
|
Blood Lactate
Time Frame: 1 minute after the protocol of eccentric contractions
|
For analysis of the amount of blood lactate as an indirect marker of fatigue, a drop of blood will be collected from the first finger on the Bm-lactate strip and read through the Accutrend Plus COBAS® Monitor.
|
1 minute after the protocol of eccentric contractions
|
Blood Lactate
Time Frame: 1 hour after the protocol of eccentric contractions
|
For analysis of the amount of blood lactate as an indirect marker of fatigue, a drop of blood will be collected from the first finger on the Bm-lactate strip and read through the Accutrend Plus COBAS® Monitor.
|
1 hour after the protocol of eccentric contractions
|
Blood Lactate
Time Frame: 24 hours after the protocol of eccentric contractions
|
For analysis of the amount of blood lactate as an indirect marker of fatigue, a drop of blood will be collected from the first finger on the Bm-lactate strip and read through the Accutrend Plus COBAS® Monitor.
|
24 hours after the protocol of eccentric contractions
|
Blood Lactate
Time Frame: 48 hours after the protocol of eccentric contractions
|
For analysis of the amount of blood lactate as an indirect marker of fatigue, a drop of blood will be collected from the first finger on the Bm-lactate strip and read through the Accutrend Plus COBAS® Monitor.
|
48 hours after the protocol of eccentric contractions
|
Blood Lactate
Time Frame: 72 hours after the protocol of eccentric contractions
|
For analysis of the amount of blood lactate as an indirect marker of fatigue, a drop of blood will be collected from the first finger on the Bm-lactate strip and read through the Accutrend Plus COBAS® Monitor.
|
72 hours after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS)
Time Frame: baseline
|
Delayed onset muscle soreness (DOMS) in the lower limb will be assessed using the Visual Analogue Pain Scale (VAS) using a 10 cm line, starting with the number 0, corresponding to no pain, and 10, corresponding to the worst possible pain.
Volunteers will be instructed to mark the line where their pain best fits at that time.
The evaluations will be performed prior to stretching and warm-up, 1 minute after the eccentric contractions protocol, and also 1, 24, 48, 72 hours after the protocol execution.
|
baseline
|
Delayed onset muscle soreness (DOMS)
Time Frame: 1 minute after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS) in the lower limb will be assessed using the Visual Analogue Pain Scale (VAS) using a 10 cm line, starting with the number 0, corresponding to no pain, and 10, corresponding to the worst possible pain.
Volunteers will be instructed to mark the line where their pain best fits at that time.
The evaluations will be performed prior to stretching and warm-up, 1 minute after the eccentric contractions protocol, and also 1, 24, 48, 72 hours after the protocol execution.
|
1 minute after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS)
Time Frame: 1 hour after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS) in the lower limb will be assessed using the Visual Analogue Pain Scale (VAS) using a 10 cm line, starting with the number 0, corresponding to no pain, and 10, corresponding to the worst possible pain.
Volunteers will be instructed to mark the line where their pain best fits at that time.
The evaluations will be performed prior to stretching and warm-up, 1 minute after the eccentric contractions protocol, and also 1, 24, 48, 72 hours after the protocol execution.
|
1 hour after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS)
Time Frame: 24 hours after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS) in the lower limb will be assessed using the Visual Analogue Pain Scale (VAS) using a 10 cm line, starting with the number 0, corresponding to no pain, and 10, corresponding to the worst possible pain.
Volunteers will be instructed to mark the line where their pain best fits at that time.
The evaluations will be performed prior to stretching and warm-up, 1 minute after the eccentric contractions protocol, and also 1, 24, 48, 72 hours after the protocol execution.
|
24 hours after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS)
Time Frame: 48 hours after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS) in the lower limb will be assessed using the Visual Analogue Pain Scale (VAS) using a 10 cm line, starting with the number 0, corresponding to no pain, and 10, corresponding to the worst possible pain.
Volunteers will be instructed to mark the line where their pain best fits at that time.
The evaluations will be performed prior to stretching and warm-up, 1 minute after the eccentric contractions protocol, and also 1, 24, 48, 72 hours after the protocol execution.
|
48 hours after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS)
Time Frame: 72 hours after the protocol of eccentric contractions
|
Delayed onset muscle soreness (DOMS) in the lower limb will be assessed using the Visual Analogue Pain Scale (VAS) using a 10 cm line, starting with the number 0, corresponding to no pain, and 10, corresponding to the worst possible pain.
Volunteers will be instructed to mark the line where their pain best fits at that time.
The evaluations will be performed prior to stretching and warm-up, 1 minute after the eccentric contractions protocol, and also 1, 24, 48, 72 hours after the protocol execution.
|
72 hours after the protocol of eccentric contractions
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Caroline M Machado, 1, University of Nove de Julho
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Vanin AA, Miranda EF, Machado CS, de Paiva PR, Albuquerque-Pontes GM, Casalechi HL, de Tarso Camillo de Carvalho P, Leal-Junior EC. What is the best moment to apply phototherapy when associated to a strength training program? A randomized, double-blinded, placebo-controlled trial : Phototherapy in association to strength training. Lasers Med Sci. 2016 Nov;31(8):1555-1564. doi: 10.1007/s10103-016-2015-7. Epub 2016 Jul 1. Erratum In: Lasers Med Sci. 2017 Jan;32(1):253.
- Miranda EF, Vanin AA, Tomazoni SS, Grandinetti Vdos S, de Paiva PR, Machado Cdos S, Monteiro KK, Casalechi HL, de Tarso P, de Carvalho C, Leal-Junior EC. Using Pre-Exercise Photobiomodulation Therapy Combining Super-Pulsed Lasers and Light-Emitting Diodes to Improve Performance in Progressive Cardiopulmonary Exercise Tests. J Athl Train. 2016 Feb;51(2):129-35. doi: 10.4085/1062-6050-51.3.10. Epub 2016 Mar 4.
- Antonialli FC, De Marchi T, Tomazoni SS, Vanin AA, dos Santos Grandinetti V, de Paiva PR, Pinto HD, Miranda EF, de Tarso Camillo de Carvalho P, Leal-Junior EC. Phototherapy in skeletal muscle performance and recovery after exercise: effect of combination of super-pulsed laser and light-emitting diodes. Lasers Med Sci. 2014 Nov;29(6):1967-76. doi: 10.1007/s10103-014-1611-7. Epub 2014 Jun 19.
- Machado CDSM, Casalechi HL, Vanin AA, de Azevedo JB, de Carvalho PTC, Leal-Junior ECP. Does photobiomodulation therapy combined to static magnetic field (PBMT-sMF) promote ergogenic effects even when the exercised muscle group is not irradiated? A randomized, triple-blind, placebo-controlled trial. BMC Sports Sci Med Rehabil. 2020 Aug 26;12:49. doi: 10.1186/s13102-020-00197-6. eCollection 2020.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 14, 2019
Primary Completion (Actual)
April 14, 2019
Study Completion (Actual)
May 14, 2019
Study Registration Dates
First Submitted
September 14, 2018
First Submitted That Met QC Criteria
October 2, 2018
First Posted (Actual)
October 4, 2018
Study Record Updates
Last Update Posted (Actual)
December 2, 2019
Last Update Submitted That Met QC Criteria
November 28, 2019
Last Verified
November 1, 2019
More Information
Terms related to this study
Other Study ID Numbers
- 617150400
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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