Gum Acacia and Blood Glucose

The Effect of Gum Acacia on Satiety, Glycemic Response and Gastrointestinal Tolerance

This study will provide needed insight on the satiety and blood glucose and l effects of the soluble fiber gum acacia at 20g and 40g doses.

Study Overview

• Status: Completed
• Conditions: Diet Modification
• Intervention / Treatment: Other: Placebo/Control; Other: Low Fiber; Other: High Fiber

Detailed Description

This is a randomized, single-blind, crossover, intervention study testing the satiety and blood glucose effects of the soluble fiber gum acacia.

• Study Type: Interventional
• Enrollment (Actual): 48
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Minnesota
    • Saint Paul, Minnesota, United States, 55108
      • Department of Food Science and Nutrition

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria: BMI between 18 and 29 kg/m2

Exclusion Criteria:

• distaste for bagels and cream cheese, orange juice or cheese pizza;
• current smoker;
• restrained eating habits;
• recent weight change;
• any history of disease or significant past medical history;
• are vegetarian;
• do not normally eat breakfast or lunch;
• pregnant or lactating;
• irregular menstrual cycles.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 0 fiber; 0 grams fiber added to orange juice	Other: Placebo/Control; No acacia gum will be added to orange juice.
Experimental: low fiber; 20 grams of acacia gum added to orange juice	Other: Low Fiber; 20 g of acacia gum will be added to orange juice
Experimental: high fiber; 40 grams of acacia gum added to orange juice	Other: High Fiber; 40 g of acacia gum will be added to orange juice

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood glucose levels	Blood will be taken via finger stick	0, 30, 60, 120, 180, and 240 minutes after breakfast; Area under the curve (AUC) will be calculated for each treatment
Appetite Sensation	Subjective visual analog scale (VAS) will be utilized to assess hunger, fullness and desire to eat	15, 30, 45, 60, 90, 120, 180 and 240 minutes after breakfast; Area under the curve (AUC) will be calculated for each treatment

Collaborators and Investigators

• Sponsor: University of Minnesota

Study record dates

Study Major Dates

• Study Start (Actual): October 9, 2018
• Primary Completion (Actual): August 31, 2019
• Study Completion (Actual): September 1, 2019

Study Registration Dates

• First Submitted: August 29, 2018
• First Submitted That Met QC Criteria: October 16, 2018
• First Posted (Actual): October 23, 2018

Study Record Updates

• Last Update Posted (Actual): October 4, 2019
• Last Update Submitted That Met QC Criteria: October 3, 2019
• Last Verified: October 1, 2019

More Information

Terms related to this study

• Other Study ID Numbers: STUDY00004203

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No