- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03765151
The Effectiveness of Low-level Laser Therapy in Orthodontic Retention for Periodontal-compromised Patients
April 27, 2021 updated by: The University of Hong Kong
The Effectiveness of Low-level Laser Therapy as an Adjunct Strategy in Orthodontic Retention for Periodontal-compromised Patients
The aim of the study is to evaluate the effects of low-level laser therapy (LLLT) on patients with chronic periodontitis during a post-orthodontic period for 12 months.
Following aspects will be assessed: 1. Effects on tooth stability maintenance and bone remodeling.
2. Effects on periodontal inflammation status.
3. Effects on cervical dentin sensitivity and quality of life.
The study design is a randomised controlled trail.
To eliminate any bias, the investigator will initially hypothesis there is no significant difference in the aforementioned aspects between teeth retained with an adjunctive LLLT strategy and those retained in a conventional regimen.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The study design is a randomised split-mouth design based on the result of investigator's pilot study.
Thirty-five non-smoking Ethnic Chinese patients (male and female, age: 25-65 years) with chronic periodontitis will be recruited.
The teeth in experimental group will receive LLLT during orthodontic retention period for 12 months, while the teeth in the control (placebo) group will not receive laser therapy.
Orthodontic occlusal indices will be measured to explore LLLT's role in maintaining tooth stability.
The effects of LLLT on periodontal inflammation status will be evaluated by assessing clinical periodontal parameters and the levels of supra-gingival and sub-gingival bacteria.
The effects of LLLT on bone remodelling will be explored by testing the biochemical biomarkers in gingival crevicular fluid (GCF).
Cone-beam computed tomography will also be used to provide clinical evidence of periodontal status and bone remodelling.
Possible effects of LLLT on patient's quality of life will be investigated via validated questionnaires, subjective assessment of tooth sensitivity, and objective measurement of bite force.
Study Type
Interventional
Enrollment (Actual)
35
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Hong Kong, Hong Kong
- The Prince Philip Dental Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
25 years to 65 years (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Thirty-five non-smoking Ethnic Chinese patients (male or female; age: 25-65 years) will be recruited from the Prince Philip Dental Hospital, Faculty of Dentistry, the University of Hong Kong into the following selection criteria:
- Systemically health (with special regard to disease affecting tissue repair);
- No medications required for periodontal therapy and no use of any antibiotic and/or anti-inflammatory medication in the preceding month;
- Chronic periodontitis with at least two pairs (clinically matched) displaced single-rooted teeth (each pair of teeth is in the same arch but in two contralateral hemi-arches respectively belonging to the same tooth typology) having at least one site probing depth of 5 mm or more, interproximal attachment loss of 3 mm or more, and radiographic signs of alveolar bone loss before periodontal and orthodontic treatment.
- Recent completion of orthodontic treatment and readiness for debonding and retainer delivery.
Exclusion Criteria:
- smoking;
- pregnancy;
- under orthodontic treatment.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: CROSSOVER
- Masking: TRIPLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: LLLT group
Low-level laser therapy and orthodontic retention
|
LLLT will be performed by a diode gallium-aluminum-arsenide (Ga-Al-As) laser with a 940-nm wavelength (Ezlase; Biolase Technology Inc., Irvine, CA) and delivered by a quadrant-sized probe which cover the region from the central incisor to the first molar on the test side.
The laser probe will be 1 cm from the soft tissue around the test tooth at the gingival margin and alveolar mucosa covering the root area using a setting of 800 milliwatt in a continuous wave.
Each tooth will receive 30 seconds of exposure, with no more than 8.6 J/cm2 of energy delivered.
In addition, a spot-size laser probe will be applied for 30 seconds 5 mm from the cervical dentin with an output power of 700 milliwatt to reduce tooth sensitivity.
All participants included will wear fixed lingual retainer and removable retainers in the post-orthodontic retention period and their previous orthodontic treatment will be carried out by one operator using preadjusted appliances with bonded 0.022×0.028-inch2
brackets/buccal tubes and 0.014-inch Nickel Titanium (NiTi) archwires as the first archwires.
|
Placebo Comparator: control group
orthodontic retention and no laser treatment.
|
All participants included will wear fixed lingual retainer and removable retainers in the post-orthodontic retention period and their previous orthodontic treatment will be carried out by one operator using preadjusted appliances with bonded 0.022×0.028-inch2
brackets/buccal tubes and 0.014-inch Nickel Titanium (NiTi) archwires as the first archwires.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in probing pocket depth (PPD)
Time Frame: debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Record the changes of probing pocket depth in millimeters from baseline to 3 months, 6 months and 12 months through probing.
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debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
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Changes in bleeding on probing (BOP)
Time Frame: debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Record the bleeding on probing changes from baseline to 3 months, 6 months and 12 months through probing.
|
debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Changes in clinical attachment loss (CAL)
Time Frame: debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Record the clinical attachment loss (CAL) changes from baseline to to 3 months, 6 months and 12 months.
|
debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Changes in plaque index (PI)
Time Frame: debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Record the plaque index (PI) changes from baseline to to 3 months, 6 months and 12 months.
|
debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Orthodontic outcome stability
Time Frame: debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Assess the changes in Little's irregularity index (LII) in maxillar and mandibular anterior teeth in millimeters by measuring both plaster models and e-models
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debond, 3 month follow-up, 6 month follow-up and 12 month follow-up
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Alveolar bone remodelling
Time Frame: debond, 12 month follow-up
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Alveolar bone remodelling will be assessed by the changes in height (measured in millimeters) and thickness (measured in millimeters) of alveolar marginal bone surrounding predetermined target teeth according to Cone Beam computed tomography.
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debond, 12 month follow-up
|
Supragingival and subgingival plaque
Time Frame: debond, 1 month follow-up, 3 month follow-up, 6 month follow-up and 12 month follow-up
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Bacteria loads in supragingival and subgingival plaques will be recorded.
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debond, 1 month follow-up, 3 month follow-up, 6 month follow-up and 12 month follow-up
|
Cervical dentin sensitivity
Time Frame: debond, each week interval during the first months, 3 months, 6 months and 12 months
|
Cervical dentin hypersensitivity will be evaluated by subjective assessment on a visual analogue scale (range from 0 to 100 mm) after a standardized stimuli applied on the test and control teeth.
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debond, each week interval during the first months, 3 months, 6 months and 12 months
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Maximum voluntary bite force
Time Frame: debond, 1 month follow-up, 3 month follow-up, 6 month follow-up and 12 month follow-up
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Use an standardized occlusal force gauge to record the magnitude of bite force in newton (N).
|
debond, 1 month follow-up, 3 month follow-up, 6 month follow-up and 12 month follow-up
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Yanqi Yang, The Prince Philip Dental Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 1, 2018
Primary Completion (Actual)
June 1, 2020
Study Completion (Actual)
December 1, 2020
Study Registration Dates
First Submitted
November 21, 2018
First Submitted That Met QC Criteria
December 3, 2018
First Posted (Actual)
December 5, 2018
Study Record Updates
Last Update Posted (Actual)
April 29, 2021
Last Update Submitted That Met QC Criteria
April 27, 2021
Last Verified
April 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HKUCTR-2390
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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