- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03767426
The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Goal 1: How does sleep deprivation impact emotion perception and memory processing? The investigators are interested in how an acute loss of sleep impairs our ability to properly perceive, consolidate, and retrieve emotional information. There has been research on the effect of sleep deprivation on broad areas of cognition, such as attention, working memory, and reasoning ability, but the impact of sleep loss on emotional processing and regulation remains largely unexplored. The investigators aim to characterize how sleep deprivation compared to undisturbed sleep affects the ability to accurately perceive emotion, how it alters the intensity with which emotions are perceived, and the effect that these changes have on the subsequent consolidation and memory retrieval for emotional compared to neutral information.
Goal 2: How are these changes reflected in the neural signal and with psychophysiological measures? The investigators will utilize functional magnetic resonance imaging (fMRI) and measures of autonomic reactivity (heart rate and skin conductance) to characterize the neural and psychophysiological mechanisms underlying these behavioral changes following sleep deprivation compared to a normal night of sleep. This will allow us to pinpoint the brain regions involved in changes following sleep deprivation, and associate these changes with effects on downstream physiological responses.
Goal 3: Can a nap after sleep deprivation restore normal processing of emotional memory and rescue the neural and autonomic markers of sleep deprivation? The investigators are interested in determining if a brief period of recovery sleep is enough to combat the behavioral, neural, and autonomic effects of acute sleep loss, thus a portion of the sleep-deprived participants will be given a 2-hour nap opportunity to quantify its restorative effects. Such information would form the foundation for future research extending and translating these findings into effective sleep-based interventions for healthy and clinical populations alike.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Tony J Cunningham, PhD
- Phone Number: 617-632-7927
- Email: acunnin4@bidmc.harvard.edu
Study Contact Backup
- Name: Robert Stickgold, PhD
- Phone Number: 617-233-3768
- Email: rstickgold@hms.harvard.edu
Study Locations
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02215
- Recruiting
- Tony Cunningham
-
Contact:
- Robert Stickgold, PhD
- Phone Number: 617-233-3768
- Email: rstickgold@hms.harvard.edu
-
Contact:
- Tony Cunningham, PhD
- Phone Number: 617-632-7927
- Email: acunnin4@bidmc.harvard.edu
-
Sub-Investigator:
- Robert Stickgold, PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- willing and able to follow the protocol
- willing and able to meet inclusion criteria for fMRI scanning
- willing to refrain from alcohol and recreational drugs for the duration of the protocol
- normal or corrected to normal vision is required
Exclusion Criteria:
- self-reported sleep disturbances
- left-handedness or ambidexterity
- a history of mental illness or neurological disorder
- the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: BASIC_SCIENCE
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
NO_INTERVENTION: Overnight sleep
Subjects are permitted a night of polysomnograph-recorded sleep before participating in training and testing sessions the next day
|
|
ACTIVE_COMPARATOR: Sleep deprivation
Subjects sleep deprived before participating in training and testing sessions the next day
|
Subjects are sleep deprived for an entire night
|
EXPERIMENTAL: Daytime Nap
Subjects are trained and then retested after a daytime nap
|
Subjects are sleep deprived for an entire night
After a night of sleep deprivation, participants will be given a 2 hour nap opportunity
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Morphed Face Accuracy and Intensity
Time Frame: 1-24 hours
|
Participants are asked to identify and rate emotional intensity of ambiguous emotional faces (happy, sad, angry) that have been morphed with neutral faces.
Scores for each emotional domain will be calculated as (i) accuracy score (number of faces correctly identified over total faces seen), and (ii) average emotional intensity rating.
Task will be completed at baseline, post-sleep/sleep deprivation, and post-nap/no nap, and within-subject comparisons will determine how interventions impact emotional perception.
|
1-24 hours
|
Emotional Memory Tradeoff Memory Score
Time Frame: 12-24 hours
|
Following sleep or sleep deprivation, participants will complete emotional memory tradeoff recognition task at two time points, separated by a nap or wakefulness.
Corrected hit rate will be calculated for negative and neutral scene components as the percentage of correctly identified "old" objects/backgrounds minus percentage of false alarms ("new" pictures marked as "old")
|
12-24 hours
|
Psychomotor vigilance task lapse rate
Time Frame: 1-24 hours
|
The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.
|
1-24 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
fMRI measured neural reactivity (blood oxygen-level dependent signal)
Time Frame: 12-24 hours
|
Following sleep or sleep deprivation, regions of interest include amygdala reactivity and connectivity between the amygdala and the ventromedial prefrontal cortex (vmPFC) in response to negative and neutral stimuli.
|
12-24 hours
|
Heart Rate Reactivity (Beats per minute)
Time Frame: 12-24 hours
|
The change in heart rate beats per minute in response to negative and neutral stimuli after sleep or sleep deprivation.
|
12-24 hours
|
Skin Conductance Reactivity (micro Siemens)
Time Frame: 12-24 hours
|
The change in electrodermal activity in response to negative and neutral stimuli after sleep or sleep deprivation.
|
12-24 hours
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Tony Cunningham, PhD, Beth Israel Deaconess Medical Center
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- TC-1
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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