- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05850767
The Effect of Sleep Deprivation on Passive and Active Functions and Distance Modulation of the Vestibulo-Ocular Reflex
The Effect of Sleep Deprivation on Passive Function, Active Function and Distance Modulation of the Vestibulo-Ocular Reflex
The goal of this cross-over clinical trial is to evaluate the effect of 24 hours sleep deprivation on the Vestibulo-Ocular Reflex (VOR) in healthy participants.
The main questions it aims to answer are:
- The effect of sleep deprivation on vestibular function.
- The difference between passive and active VOR function following sleep deprivation.
- The vergence mediated modulation ability of the VOR following sleep deprivation.
- The effect of sleep deprivation on behavioral VOR function.
Participants will be tested before and after a normal night sleep and during 24 hours of sleep deprivation.
Study Overview
Detailed Description
The study will include two sleep protocols: Normal sleep and 24h sleep deprivation. The participants will be informed and will sign a consent form. Participants will then be randomly divided to begin with one of the sleep protocols. To avoid major changes in participants lifestyle, that might intervene with the basic measurements, both nights will take place within a maximum of one month and a minimum of one week for recovery between them. One week prior to each condition, participants will fill a sleep diary which will include their sleep duration to ensure that a routine sleep pattern will be maintained prior to each of the tests. Participants will be instructed not to consume alcoholic drinks or mind-altering substances for 24h prior, and during both conditions, and caffeine for 12h prior and during both conditions.
To enable normal sleep as possible, the normal sleep protocol will take place in each of the participants home. Matching environmental conditions will be kept to those of the clinic (lighting, white background) where the sleep deprivation protocol will be held. The participants will be tested using the Video Head Impulse test (vHIT) and the Computerized Dynamic Visual Acuity test (c-DVA) during both nights. The participants will be equipped with an ActiGraph watch wGT3X-BT to assure sleeping conditions.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Yoav Gimmon, PhD
- Phone Number: +972-50-6442243
- Email: ygimmon@univ.haifa.ac.il
Study Contact Backup
- Name: Hadas Ben-Rubi Shimron, M.Sc.PT
- Phone Number: +972-54-7780224
- Email: hadas.vpt@gmail.com
Study Locations
-
-
-
Haifa, Israel
- Recruiting
- University of Haifa
-
Contact:
- Yoav Gimmon, PhD
- Phone Number: +972-50-6442243
- Email: ygimmon@univ.haifa.ac.il
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Age 30-60 years old
- Healthy
- Persons who are not night shift workers
- Persons who are not used to but can keep awake for 24 hours
Exclusion Criteria:
- Night shift workers
- Vestibular system deficiency in vHIT test
- Active neurological disease
- Any orthopedic deficit in the cervical area preventing a proper vHIT examination
- A diagnosed sleep disorder or >5 score in the Pittsburgh sleep quality questionnaire Hebrew version (PSQI)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Sleep deprivation
Participants will stay fully awake for 24 hours.
|
Participants will stay fully awake for 24 hours
|
No Intervention: Normal sleep
Participant will sleep a normal night sleep.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
VOR gain
Time Frame: 9pm before and 6am after normal sleep. 9pm, 2am and 6am during sleep deprivation.
|
The calculated ratio between eye velocity and head velocity during brief head movements
|
9pm before and 6am after normal sleep. 9pm, 2am and 6am during sleep deprivation.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Logarithm of the Minimum Angle of Resolution (logMAR)
Time Frame: 6am following normal sleep and 6am during sleep deprivation.
|
Units measuring visual acuity
|
6am following normal sleep and 6am during sleep deprivation.
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Yoav Gimmon, Phd, University of Haifa, Haifa, Israel
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 206/22
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ICF
- CSR
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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