The Effect of Frailty on Balance, Activities of Daily, and Exercise Capacity in COPD

The Effect Of Frailty Level On Balance, Cognition And Activities Of Daily Living In COPD

The investigators aim to demonstrate whether balance, cognition and activities of daily living have changed in COPD patients with and without frailty.

Study Overview

• Status: Completed
• Conditions: Frailty; COPD

Detailed Description

COPD is a common, preventable and treatable disease characterized by progressive respiratory symptoms and airflow limitation. Frailty defines a clinical syndrome characterized by multiple system effects, leading to decreased functional reserve and increased sensitivity to dependence or mortality following minor stress events. Inflammation, lack of physical activity, reduced exercise efficiency and maximum oxygen uptake may contribute to the development of frailty in patients with COPD. Balance, cognition and activities of daily living are associated with COPD.

This study will evaluate the effect of frailty on balance, cognition and activities of daily living in patients with COPD.

• Study Type: Observational
• Enrollment (Actual): 48

Contacts and Locations

Study Locations

• Turkey
  • Sihhiye
    • Ankara, Sihhiye, Turkey, 06100
      • Hacettepe University Faculty of Health Sciences Department of Physiotherapy and Rehabilitation

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 55 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Individuals who are diagnosed with COPD at Hacettepe University and who are referred to the Cardiopulmonary Rehabilitation Unit for physiotherapy also who are willing to participate in the study will be included in the study.

Description

Inclusion Criteria:

• COPD patients who have been clinically stable for the last four weeks and who have not undergone drug change for the last four weeks
• Being 55 years of age or older
• Accepted to participate in the study (Able and wililing to complete the informed consent process)
• Co-operate
• Patients with COPD who are ambulant without support or an assistive device

Exclusion Criteria:

• Neurological, cardiac or orthopedic diseases
• Other chronic diseases that may affect balance and walking

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Frail patients with COPD; No intervention
Non-frail patients with COPD; No intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Presence of The Frailty Will Be evaluated Using The Frailty Criteria by Fried	Frailty will be identified by the presence of three or more of the following criteria unintentional weight loss (10 Ibs in past year), weakness (grip strength), self-reported exhaustion, slow walking speed and low physical activity. Patients with three or more of the criteria present were classified as frail.	1st Day
Balance Assessment Using Functional Reach Test	The Functional Reach Test measures how far patient can reach forward from a normal relaxed stance.	1st Day
Cognition Using MoCA-Test	Cognitive function will be evaluated with the secreening tool the Montreal Cognitive Assessment (MoCA). The MoCA is a 30-point screening tool.	1st Day
Perform activities of daily living (ADL) will be evaluated using the Glittre ADL-test	Glittre ADL-test was designed specifically to assess the functional limitation in patients with COPD. Glittre ADL-test time will be considered the main outcome variable, and will be recorded in minutes (metric).	1st Day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Exercise Capacity Using 6-Minute Walk Test	The standard protocol of the test is applied in a 30-meter continuous corridor. Standard instructions are given during testing.	1st Day
Disease-Related Quality of Life Assessment	COPD evaluation test (CAT) was developed to help assess health status.	1st Day
Respiratory Muscle Strength Assessment	Respiratory muscle strength will be evaluated by non-invasive methods by measuring maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP).	1st Day
Shortness of Breath Assessment	Modified Medical Research Council (mMRC) dyspnea scale will be used to determine the shortness of breath severity.	1st Day

Collaborators and Investigators

• Sponsor: Hacettepe University
• Investigators: Principal Investigator: Deniz Inal-Ince, PhD, Hacettepe University

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2018
• Primary Completion (Actual): October 15, 2019
• Study Completion (Actual): October 15, 2019

Study Registration Dates

• First Submitted: February 12, 2019
• First Submitted That Met QC Criteria: February 12, 2019
• First Posted (Actual): February 15, 2019

Study Record Updates

• Last Update Posted (Actual): December 1, 2023
• Last Update Submitted That Met QC Criteria: November 30, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Keywords: Balance; COPD; Cognition; Activities of Daily Living; Frailty
• Additional Relevant MeSH Terms: Pathologic Processes; Frailty
• Other Study ID Numbers: GO 18/83-22

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No