- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03934749
Non-invasive Home Ventilation in Patients With Severe Hypercapnic Chronic Obstructive Pulmonary Disease (SOMNOVENT')
Non-invasive Home Ventilation in Patients With Severe Hypercapnic COPD: Standard Versus Löwenstein Mode of Management of Dynamic Hyperinflation; Effects on Hematosis and Sleep.
In COPD patients with chronic hypercapnic respiratory failure, the prognosis is poor and the treatment with non invasive ventilation is actually well established. However the best mode of ventilation is not well known.
In severe COPD patients various disorders of respiratory mechanics result in insufficient ventilation, which can be life-threatening or create NIV discomfort. The main characteristic of these disorders is a cyclical closing of small airways that can limit an expiratory flow and provoked some fluctuations in flow curve. To our knowledge, the management of dynamic hyperinflation seems to play an important role in explaining the effect of the NIV. Few studies have examined the effects of the machine's adjustments on dynamic hyperinflation.
The main objective of this study is to analyze the impact of specific ventilatory modes supposed to reduce the dynamic hyperinflation on the hematosis, by studying transcutaneous pressure of carbon dioxide, in severe hypercapnic COPD patients ventilated by NIV. Two modes of ventilation will be compared. First one is an algorithmic mode developed by the company Löwenstein (AirTrap Control, Trigger Lockout and the Expiratory Pressure Ramp). The second one is a standard algorithmic mode, used in the same ventilator. These two ventilatory modes will be evaluated in each patient, during two consecutive nights in current living conditions at home.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Doubs
-
Besançon, Doubs, France, 25000
- CHRU Jean Minjoz
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Diagnosis of COPD using Gold 2017 criterion
- Optimal medical treatment of COPD, ie. inhaled steroids, long-acting β2-agonist, long-acting anticholinergic, according to GOLD 2017 guidelines.
- At least one acute exacerbation of COPD with hypercapnic respiratory failure
- Introduction of NIV distant to acute exacerbation of COPD with persisting hypercapnia (> 7kPa) on arterial blood gas at rest.
- NIV equipment from the service provider "Don Du Souffle (DDS)".
- Patient able to give their consent
Exclusion Criteria:
- Contraindication to NIV (consensus conference of SFAR-SPLF-SRLF)
- Obstructive sleep apnea with apnea/hypopnea index > to 20/h
- BMI > 35 kg/m2
- Low compliance with NIV treatment (<3h per day)
- Acute exacerbation COPD during inclusion or pH <7.30 in routine blood gas arterial
- Severe heart failure (New York Heart Association stage IV/IV)
- Unstable angina
- Severe arrhythmias
- Severe renal insufficiency stage > 4
- Other conditions than COPD resulting in hypercapnia
- Pregnancy
- Patient without health insurance
- Patient excluded by another study
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Crossover
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
standard mode
after adjusting pressure and different modes of ventilation to each individual patient.
Each one of them will receive NIV using Löwenstein mode during one night at home.
Patients will be under transcutaneous PCO2 measurement and polysomnographic surveillance.
|
NIV using standard mode or Lowenstein mode
|
Lowenstein mode
after adjusting pressure and different modes of ventilation to each individual patient.
Each one of them will receive NIV without Löwenstein mode during one night at home.
Patients will be under transcutaneous PCO2 measurement and polysomnographic surveillance.
|
NIV using standard mode or Lowenstein mode
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Mean carbon dioxide partial pressure-level during non invasive ventilation
Time Frame: 2 nights
|
Mean pCO2 level over night calculated using transcutaneous measurement of partial pressure of carbon dioxide under non invasive ventilation.
Device : transcutaneous capnography (PtcCO2); SenTec Digital Monitoring System
|
2 nights
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of respiratory events during non invasive ventilation
Time Frame: 2 nights
|
According to consensus group, nocturnal respiratory events are : unintentional leak, obstruction at different levels of the upper airways and asynchrony (ineffective effort, auto-triggering, and double triggering, premature or delayed cycling)
|
2 nights
|
Sleep quality
Time Frame: 2 nights
|
Changes in data of polysomnography (total sleep time (TST) ; total recording time ; sleep latency, sleep efficiency (TST/time in bed) ; time in each stages plus percent of TST in each stage ; stage REM latency ; wake time after sleep onset ; arousal index)
|
2 nights
|
Ventilation quality
Time Frame: 2 nights
|
Subjective changes in quality of ventilator by specific auto questionnaire (quality of night, feeling, dyspnea, quality of ventilation, respiratory disturbance caused by NIV, sleep disturbance caused by NIV).
The patient answers to each question using a "likert scale" in terms of intensity.
The second questionnaire is the S3-NIV which is a tool for the routine clinical assessment of patients undergoing home NIV.
|
2 nights
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2018-A02135-50
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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