Plasma Rich in Growth Factors in Post-extraction Sockets

May 9, 2026 updated by: Pablo Galindo-Moreno, Universidad de Granada

Clinical Behavior and Molecular Pathways of PRGF in Post-extraction Sockets

The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Spain
    • Granada
      • Granada, Granada, Spain, 18071
        • Facultad de Odontología

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

14 years to 71 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant.
  • Adjacent and opposing natural teeth present and healthy.
  • At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal.

Exclusion Criteria:

  • Active local infection.
  • Uncontrolled diabetes mellitus.
  • Long term (>10 years) use of oral bisphosphonates.
  • Use of intravenous bisphosphonates.
  • Recent use (<3 months) of antibiotics, antiinflammatories or analgesics drugs.
  • Pregnancy.
  • Smokers of more than 10 cigarettes per day.
  • Any oral pathology that needs to be treated before tooth extraction, particularly the presence of more than 25% of sites with bleeding on probing.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: PRGF
Post-extraction socket grafted with PRGF-Endoret
Device: PRGF
After tooth extraction, the socket will be grafted with PRGF-Endoret
Other Names:
  • PRGF-Endoret
Active Comparator: ABB
Post-extraction socket grafted with anorganic bovine bone (ABB)
Device: ABB
After tooth extraction, the socket will be grafted with Geistlich Bio-Oss® Collagen
Other Names:
  • Geistlich Bio-Oss® Collagen

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Alveolar bone change in Cone Beam Computerized Tomography
Time Frame: Baseline and 4 months
Volumetric change in the alveolar bone from immediately after tooth extraction to immediately before implant placement (4 months after the extraction and grafting of the socket)
Baseline and 4 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Universidad de Granada

Collaborators

BTI Biotechnology Institute

Investigators

  • Principal Investigator: Pablo Galindo-Moreno, DDS, PhD, Universidad de Granada

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 4, 2019

Primary Completion (Actual)

November 18, 2024

Study Completion (Actual)

October 30, 2025

Study Registration Dates

First Submitted

May 7, 2019

First Submitted That Met QC Criteria

May 7, 2019

First Posted (Actual)

May 9, 2019

Study Record Updates

Last Update Posted (Actual)

May 12, 2026

Last Update Submitted That Met QC Criteria

May 9, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 1962-N-18

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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