- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03957811
Effect of Whole-body Vibration on TcPO2 (WBV)
Intervention Project for Diabetic Foot Prevention Through the Development of a Vibratory Therapy Program at the National Rehabilitation Institute LGII
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Objective: To determine the effect of whole body vibration exercise on levels of TcPO2 measured in the feet of patients with type 2 diabetes, in order to create recommendations for prevention of diabetic foot.
Material and Methods: controlled open clinical trial consisting in 2 arms, as follows: 1) control group under care for type 2 diabetes, and 2) intervention group, who, in addition to the standard care, will undergo an exercise program of whole body vibration three times a week, with progressive intensity, for a period of 12 weeks. Partial pressure of transcutaneous oxygen (TcPO2) will be measured in the feet of the participants at baseline and after 12 weeks, with 40 patients per group.
Statistical analysis: demographic information of the subjects will be described as arithmetic means, standard deviation, percentages, frequencies. Comparison between groups will be done with Student t for independent data or Mann-Whitney U when convenient. Baseline and final measurements will be compared. inter and intra group comparisons will be made by repeated measurements. For qualitative values, chi square will be used. Multivariate analysis will be performed to control for confounding variables. The level of significance will be a value of 0.05.
Study Type
Enrollment (Anticipated)
Phase
- Phase 3
Contacts and Locations
Study Locations
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DF
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Mexico City, DF, Mexico, 14389
- Recruiting
- Instituto Nacional De Rehabilitacion
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Contact:
- Gerardo Rodriguez Reyes, MS
- Phone Number: 13221 5559991000
- Email: grodriguezreyes@gmail.com
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:• Patients with diagnosis of type 2 diabetes less than or equal to six years, under care and having concluded the 4th or 5th medical visit.
- Non-smokers.
- Residents of Mexico City
- Both sexes.
- 40 to 69 years old.
- Agreeing to participate through signature of informed consent.
- HbA1c between 6.0 and 9.0 %.
- Blood pressure less than or equal to130/80.
- Total cholesterol ≤ 240 mg/dL, triglycerides ≤300 mg/dL.
- Stable weight over the last 6 months ( <10% variation).
Exclusion Criteria:• Patients with severe motor handicap and amputations of pelvic members.
- With exposed lesions in subcutaneous tissue (ulcers) in the sole of the foot, diabetic foot (Wagner 3 or more) or intermittent claudication.
- With important alterations in balance.
- With a recent surgery.
- Gravidity.
- Deep venous thrombosis.
- With pacemaker.
- Recent myocardial ischemia.
- Orthopedic implants.
- Recently-placed mammary prosthesis.
- Exoskeletal prosthesis.
- Discopathies.
- Neoplasia in the last 5 years.
- History of 2 episodes of severe hypoglycemia in the last year.
- Chronic kidney disease with creatinine clearance estimated at <60 ml/min.
- Severe non-proliferative retinopathy, uncontrolled macular edema.
- Hepatic failure (Child-Pugh "C") and/or heart failure (functional Class - NYHA-: III-IV).
- Patients with hemoglobinopathies, severe anemia (≤7.5 g/dL), known hemolytic disease.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: Controls
Subjects under treatment for diabetes will receive the standard treatment for their condition.
|
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Experimental: Intervention
Subjects under treatment for diabetes not diagnosed for diabetic foot will receive the standard treatment plus exercise on a vibrator platform for a period of 12 weeks.
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Intervention will consist of sessions of exercise on a whole body vibration platform, three times a week for 12 weeks.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Effect of whole body vibration on TcPO2 levels
Time Frame: 12 weeks
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To know the effect of whole body vibration on TcPO2 levels measured in the foot in patients with type 2 diabetes
|
12 weeks
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Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2416
- 2234 (Other Identifier: Instituto Nacional de Ciencias Médicas y Nutrición)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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