EAMA Sarcopenia in Acute Care Patients in 9+European Countries (EAMA9+)

Sarcopenia in Acute Care Patients: Protocol for the European Collaboration of Geriatric Surveys: Sarcopenia 9+ European Academy for Medicine of Ageing (EAMA) Project

This collaborative study in 9 geriatrics units across Europe aims to apply emerging research to clinical practice, following the "Action-Research Philosophy" (11). The overall goal is to improve care in patients with - and help prevent - sarcopenia. Understanding the frequency of and risk factors for developing sarcopenia in an acute hospital setting, may help shed light on potential interventions and thus inform the development of future therapeutic strategies. It involves crucial implications for research, clinical practice, and policy towards optimal aging.

Study Overview

• Status: Terminated
• Conditions: Malnutrition; Sarcopenia
• Intervention / Treatment: Other: Observational study, no interventions expected

Detailed Description

Background: Sarcopenia is a nutrition-related disease leading to physical impairment and adverse clinical outcomes. Data regarding its characteristics in hospitalized patients are limited.

Aim: This study will assess in older patients admitted to acute medical wards, the prevalence, incidence, and risk factors for development of sarcopenia, or alteration in its severity, and evaluate associated clinical adverse outcomes.

Methods: This collaboratively-designed, longitudinal prospective observational study will be carried out in patients aged >70 admitted to acute geriatric units in 9 European centers. The new sarcopenia diagnostic criteria of the European Working Group on Sarcopenia 2 (EWGSOP2) will be tested at admission and discharge, using isometric handgrip dynamometry, gait speed, and, pragmatically, calf circumference. There will be 3- and 12-month telephone follow-up (including the SARC-F questionnaire).

Discussion: Our study will be the first collaboration to assess the prevalence and incidence of sarcopenia (EWGSOP2) and its risk factors in hospitalized patients across Europe.

• Study Type: Observational
• Enrollment (Actual): 366

Contacts and Locations

• Study Contact: Name: Dolores Sanchez Rodriguez, MD PhD; Phone Number: +32 493 63 27 50; Email: dolores.sanchez@uliege.be
• Study Contact Backup: Name: Nele Van Den Noortgate, MD PhD; Phone Number: +32 476 03 50 96; Email: nele.vandennoortgate@uzgent.be

Study Locations

• Spain
  • Barcelona, Spain, 08003
    • Sanchez Rodríguez

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 70 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Older patients hospitalized in acute care units due to medical processes

Description

Inclusion Criteria:

• Patients aged >70 admitted to acute hospital medical units

Exclusion Criteria:

• Length of hospital stay anticipated to be <24 hours
• Hip/lower limb fractures
• Major amputations of the lower leg
• Terminally ill patients admitted for palliative care

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Prevalence of sarcopenia as defined by the European consensus on definition and diagnosis (EWGSOP2)	Prevalence sarcopenia in acute hospitalized older patients.	One year (March 2019-March 2020)
Incidence of sarcopenia as defined by the European consensus on definition and diagnosis (EWGSOP2)	Incidence of sarcopenia in acute hospitalized older patients.	One year (March 2019-March 2020)

Collaborators and Investigators

• Sponsor: Parc de Salut Mar
• Collaborators: Charles University, Czech Republic; Karolinska Institutet; Jagiellonian University; Catholic University of the Sacred Heart; University Hospital, Ghent; University of Exeter; Slagelse Hospital; Université Libre de Bruxelles; NOVA Medical School; Agaplesion Bethesda Clinic Ulm, Ulm, Germany

Publications and helpful links

General Publications

• Sanchez-Rodriguez D, Hope S, Piotrowicz K, Benoit F, Czesak J, Dallmeier D, Decker G, De Spiegeleer A, Hojmann AH, Hrnciarikova D, Marco E, Mendes D, Meza D, Nascimento P, Rodrigues A, Surquin M, Toscano-Rico M, Vankova H, Vetrano DL, Gasowski J, Van Den Noortgate N, Landi F. Sarcopenia in Acute Care Patients: Protocol for the European Collaboration of Geriatric Surveys: Sarcopenia 9+ EAMA Project. J Am Med Dir Assoc. 2019 Nov;20(11):e1-e3. doi: 10.1016/j.jamda.2019.04.030. Epub 2019 Jun 21. No abstract available.

Helpful Links

• Sarcopenia in Acute Care Patients: Protocol for the European Collaboration of Geriatric Surveys: Sarcopenia 9+ EAMA Project.

Study record dates

Study Major Dates

• Study Start (Actual): March 6, 2019
• Primary Completion (Actual): April 2, 2021
• Study Completion (Actual): April 2, 2023

Study Registration Dates

• First Submitted: March 6, 2019
• First Submitted That Met QC Criteria: July 29, 2019
• First Posted (Actual): July 31, 2019

Study Record Updates

• Last Update Posted (Actual): April 5, 2023
• Last Update Submitted That Met QC Criteria: April 2, 2023
• Last Verified: April 1, 2023

More Information

Terms related to this study

• Keywords: Sarcopenia; Hospitalized; Older people; Malnutrition; EWGSOP2; Acute care
• Additional Relevant MeSH Terms: Nervous System Diseases; Neurologic Manifestations; Nutrition Disorders; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Sarcopenia; Malnutrition
• Other Study ID Numbers: 2018/8355/I

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No