MultiOrgan Multi-Parametric MRI Study (MORIS)

November 27, 2025 updated by: Perspectum
To determine the reproducibility of a single quantitative multiparametric MRI for the assessment of body composition and multiple organ structures.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

43

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
      • Oxford, United Kingdom, OX4 2LL
        • Gemini One
      • Oxford, United Kingdom, OX1 2EH
        • Beaver House
      • Oxford, United Kingdom, OX3 9DU
        • Oxford Centre for Magnetic Resonance

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Adult volunteers, including healthy volunteers and individuals with Type 2 Diabetes (T2D).

Description

Inclusion Criteria:

  • Any person over 18 years of age.
  • Participant is willing and able to give informed consent for participation in the investigation.
  • EITHER: Participant has Type 2 Diabetes OR: Person is a healthy volunteer

Exclusion Criteria:

  • The participant may not enter the investigation if they have any contraindication to magnetic resonance imaging (incl. pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia).
  • Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the investigation, or may influence the result of the investigation, or the participant's ability to participate in the investigation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Other
  • Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assessment of repeatability (precision under the same conditions in the same subjects: 2 separate MRI acquisitions on the same scanner) of body composition and multiple organ metrics.
Time Frame: 24 months
To determine the repeatability of multiparametric MRI in the assessment of body composition and multiple organ structures obtained within a single MR scanning session (liver, pancreas, aorta, heart, kidney, lungs and spleen)
24 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assessment of the reproducibility (precision under different measurement conditions: same participants scanned on separate MRI scanners at both 1.5T and 3T) of multiparametric MRI for the assessment of body composition and multiple organ metrics.
Time Frame: 24 months
To determine the reproducibility of multiparametric MRI in the assessment of body composition and multiple organ structures (liver, pancreas, aorta, heart, kidney, lungs and spleen) obtained within separate MR scanning sessions.
24 months

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assessment of the mean differences in body composition and multiple organ metrics between healthy participants and those with type 2 diabetes acquired with multiparametric MRI.
Time Frame: 24 months
To determine the range of body composition and multi-organ metrics (liver, pancreas, aorta, heart, kidney, lungs and spleen) in healthy participants and in those with type 2 diabetes assessed using multiparametric MRI.
24 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Perspectum

Investigators

  • Study Chair: Rajarshi Banerjee, Perspectum

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 4, 2019

Primary Completion (Actual)

November 25, 2023

Study Completion (Actual)

November 25, 2023

Study Registration Dates

First Submitted

October 22, 2019

First Submitted That Met QC Criteria

October 22, 2019

First Posted (Actual)

October 24, 2019

Study Record Updates

Last Update Posted (Actual)

December 1, 2025

Last Update Submitted That Met QC Criteria

November 27, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CA0080

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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