- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04191265
Cardiotoxicity of Aluminum Phosphide Poisoning; Tropinin and CKmb as Early Biomarkers
May 11, 2020 updated by: Doaa Mohamed Abd El-Rahman, Assiut University
Cardiotoxicity of Aluminum Phosphide Poisoning; Biochemical and Electrophysiological Studies and the Utility of Tropinin and CKmb as Early Biomarkers
Aluminum phosphide (AlP) or rice tablet is a cheap pesticide.
When it comes in contact with acid (gastric acid) or moisture, it releases phosphine (PH3) gas.
The heart,lungs, liver are the main targets in acute Aluminum phosphide (AlP) poisoning.
Most deaths occur due to cardiovascular toxicity.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
Aluminium phosphide is a potent respiratory chain enzyme inhibitor.
Its most important effect is the inhibition of cytochrome c oxidase.
The inhibition of cytochrome c oxidase and other enzymes leads to the generation of superoxide radicals and cellular peroxides , and subsequent cellular injury through lipid peroxidation and other oxidant mechanisms.
It stimulates the production of hydrogen peroxide and reactive oxygen species, malonyldialdehyde (MAD), increases superoxide dismutase and inhibits catalase, peroxidase and glutathione .
Oxidative stress is one of the main mechanisms of action of aluminium phosphide toxicity
Study Type
Observational
Enrollment (Actual)
60
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Assiut, Egypt, 71515
- Doaa
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- ADULT
- OLDER_ADULT
- CHILD
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Assiut governorate
Description
Inclusion Criteria: ALP poisoned cases
- admitted with free ECG
Exclusion Criteria:
concomitant ingesion of other drugs or toxins
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Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury
Time Frame: 6 months
|
assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury
|
6 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
December 5, 2019
Primary Completion (ANTICIPATED)
June 5, 2020
Study Completion (ANTICIPATED)
June 5, 2020
Study Registration Dates
First Submitted
December 5, 2019
First Submitted That Met QC Criteria
December 6, 2019
First Posted (ACTUAL)
December 9, 2019
Study Record Updates
Last Update Posted (ACTUAL)
May 13, 2020
Last Update Submitted That Met QC Criteria
May 11, 2020
Last Verified
May 1, 2020
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- cardiotoxicity of ALP cases
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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