- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04222751
Static Muscular Stretching for Treatment of PAD
February 22, 2023 updated by: Judy Delp, Florida State University
Static Muscular Stretching for Treatment of Peripheral Artery Disease
Patients with peripheral arterial disease (PAD) often have walking impairment due to insufficient oxygen supply to skeletal muscle.
The investigator's pilot study in PAD patients has shown that endothelial function and walking distance improve with regular static muscle stretching.
Therefore, the purpose of this study is to determine whether prescriptive muscle stretching improves muscle oxygenation and walking ability in PAD patients.
This is a single-blinded study in 40 patients with stable symptomatic PAD.
Patients assigned to the stretch group will use ankle splints (both legs) to perform static muscle stretching for 4 weeks (ankle dorsiflexion applied 30 min/d, 5 days/wk).
Patients assigned to the control group will also wear the ankle splints daily but without invoking any dorsiflexion, i.e., without stretching.
Measurements will consist of ankle-brachial index (ABI) at rest and post-exercise, skeletal muscle oxygenation (evaluated with near-infrared spectroscopy (NIRS)), and 6 minute walk test (6MWT), performed at baseline and after 4 weeks of stretching (or control splint placement).
In addition, NIRS will be used to evaluate muscle oxygenation while patients are wearing the splint device in order to quantitatively prescribe the angle of dorsiflexion that provides optimum stretch and deoxygenation of the calf muscles without causing pain.
Primary outcomes include increased muscle oxygenation during exercise and walking distance after 4 weeks of static muscle stretching.
Results from this study will be used to support funding applications for a larger efficacy trial.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
40
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Mauricia Buchanan, RN
- Phone Number: 904-953-2077
- Email: buchanan.mauricia@mayo.edu
Study Contact Backup
- Name: Albert Hakaim, MD
- Phone Number: 904-953-2077
- Email: hakaim.albert@mayo.edu
Study Locations
-
-
Florida
-
Jacksonville, Florida, United States, 32224
- Recruiting
- Mayo Clinic Florida
-
Contact:
- Mauricia Buchanan, RN
- Phone Number: 904-953-2077
- Email: buchanan.mauricia@mayo.edu
-
Contact:
- Albert Hakaim, MD
- Phone Number: 904-953-2077
- Email: hakaim.albert@mayo.edu
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years to 100 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Age 40+
- A resting ankle-brachial index (ABI) of 0.90 or less in either leg
- Stable disease (PAD) for a minimum of 3-months
Exclusion Criteria:
- Habitual exercise (30 minutes of continuous activity for 3 or more days per week)
- Cardiovascular rehabilitation program during the past 3 months
- Below or above-knee amputation, critical limb ischemia (ulceration or gangrene)
- Leg pain at rest
- Cardiorespiratory disease
- Diabetes
- Major surgery or lower extremity revascularization during the previous 3 months
- Major medical illness treatment during the prior 12 months
- Central neurological disease
- Limited ankle or knee joint range of motion
- Requirement of oxygen with activity or exercise
- More than a class II New York Heart Association level of heart failure
- Wheelchair confinement, or inability to walk
- Cognitive disorder
- Vasculitis problem including Takayasu's arteritis, Buerger's disease, collagen disease or Raynaud's disease
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Stretch Group
Subjects assigned to this group will be instructed on how to wear the device to produce the appropriate amount of dorsiflexion (stretch).
Splint devices will be worn at the assigned angle 5 days/week, 30 minutes/day, for 4 weeks.
ABI, muscle oxygenation, and walking distance will be assessed pre/post stretching.
Other health surveys will be administered.
|
Ankle splint will be slightly modified from the commercial form to include a pneumatic air cell secured under the forefoot below the splint's padded lining.
This replaces the foam wedge provided by the manufacturer, allowing a gradual adjustment of the forefoot/toe region.
|
Placebo Comparator: No Stretch Group
Subjects assigned to this group will wear the splints but instructed to wear the device in a position that produces no stretch.
Splint devices will be worn at the assigned angle 5 days/week, 30 minutes/day, for 4 weeks.
ABI, muscle oxygenation, and walking distance will be assessed pre/post stretching.
Other health surveys will be administered.
|
Ankle splint will be slightly modified from the commercial form to include a pneumatic air cell secured under the forefoot below the splint's padded lining.
This replaces the foam wedge provided by the manufacturer, allowing a gradual adjustment of the forefoot/toe region.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Muscle Oxygenation
Time Frame: 4 weeks
|
Noninvasive assessment via NIRS monitor
|
4 weeks
|
Change in Continuous Walking Distance
Time Frame: 4 weeks
|
Assessed by 6-minute walking test
|
4 weeks
|
Change in Total Walking Distance
Time Frame: 4 weeks
|
Assessed by 6-minute walking test
|
4 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Judy Delp, PhD, Florida State University, College of Medicine
- Principal Investigator: Emily Pritchard, PhD, Florida State University, College of Medicine
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 29, 2020
Primary Completion (Anticipated)
December 31, 2023
Study Completion (Anticipated)
December 31, 2023
Study Registration Dates
First Submitted
January 7, 2020
First Submitted That Met QC Criteria
January 8, 2020
First Posted (Actual)
January 10, 2020
Study Record Updates
Last Update Posted (Actual)
February 24, 2023
Last Update Submitted That Met QC Criteria
February 22, 2023
Last Verified
February 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 19-005234 Mayo
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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