- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04242875
The Effects of Angle Kappa on Clinical Outcomes With the PanOptix Intraocular Lens
June 8, 2022 updated by: Carolina Eyecare Physicians, LLC
Evaluation of Angle Kappa and Different Intraocular Lens Calculation Formulas in Acrysof® IQ Panoptix Intraocular Lens Outcomes, Visual Disturbances and Patient Satisfaction
Angle Kappa is considered a potential factor in explaining suboptimal outcomes with intraocular lenses (IOLs), particularly multifocal IOLs.
Some evidence suggests this is not the case.
This study was designed to investigate correlations between angle kappa and post-surgical outcomes with a trifocal IOL.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The main complaint of patients who received a presbyopia correcting lens (regardless of the design) are visual disturbances such as glare, halos (rings around lights), starbursts (rays around light sources), mainly at night.
The degree of limitation or how bothered patients are varies from patient to patient.
To explain these symptoms different theories have been proposed including splitting the light into different focal points which decreases the intensity of the light reaching the retina.
Most factors are common to all patients who received the lens; however, patients are not equally affected by these symptoms.
Angle kappa has been considered a factor.
Angle κ is the angle between the visual axis (straight line that passes through both the center of the pupil and the center of the fovea) and the pupillary axis (perpendicular line to the surface of the cornea that passes through the center of the pupil).
Study Type
Observational
Enrollment (Actual)
30
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
South Carolina
-
Mount Pleasant, South Carolina, United States, 29464
- Carolina EyeCare Physicians, LLC
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Subjects undergoing bilateral lens extraction and implantation of the presbyopia correcting lens PanOptix.
Description
Inclusion Criteria:
- Subject is undergoing bilateral lens extraction with intraocular lens implantation (PanOptix lens).
- Willing and able to provide written informed consent for participation in the study
- Willing and able to comply with scheduled visits and other study procedures.
- Scheduled to undergo standard cataract surgery with topical anesthesia in both eyes within 6 to 30 days between surgeries.
- Subjects who require an IOL power in the range of +6.0 D to +30.0 D only.
- Subjects who require a TFNT00 or TFNT30 to TFNT60 IOL.
- Potential postoperative visual acuity of 0.2 logMAR (20/32 Snellen) or better in both eyes.
Exclusion Criteria:
- Severe preoperative ocular pathology
- Subjects who require a higher toric power than the one available (TFNT60).
- Uncontrolled diabetes.
- Use of any systemic or topical drug known to interfere with visual performance.
- Contact lens use during the active treatment portion of the trial.
- Any concurrent infectious/non-infectious conjunctivitis, keratitis or uveitis.
- Clinically significant corneal dystrophy
- History of chronic intraocular inflammation.
- History of retinal detachment.
- Pseudoexfoliation syndrome or any other condition that has the potential to weaken the zonules.
- Previous ocular surgery.
- Severe dry eye
- Pupil abnormalities
- Anesthesia other than topical anesthesia (i.e. retrobulbar, general, etc).
- Any clinically significant, serious or severe medical or psychiatric condition that may increase the risk associated with study participation or may interfere with the interpretation of study results.
- Participation in (or current participation) any ophthalmic investigational drug or ophthalmic device trial within the previous 30 days prior to the start date of this trial.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
PanOptix
Participants will receive the PanOptix intraocular lens.
|
Angle kappa will be measured using the OPD III scan.
Questionnaire evaluating visual disturbances.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Effect of Angle Kappa in Visual Disturbances
Time Frame: 3 months
|
Frequency of visual disturbances with magnitude of Angle Kappa
|
3 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Satisfaction With Vision by Magnitude of Angle Kappa
Time Frame: 3 months
|
Overall satisfaction score after surgery, categorized by magnitude of angle kappa
|
3 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Kerry Solomon, Carolina Eyecare Physicians
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 21, 2020
Primary Completion (Actual)
April 27, 2021
Study Completion (Actual)
April 27, 2021
Study Registration Dates
First Submitted
January 21, 2020
First Submitted That Met QC Criteria
January 23, 2020
First Posted (Actual)
January 27, 2020
Study Record Updates
Last Update Posted (Actual)
March 17, 2023
Last Update Submitted That Met QC Criteria
June 8, 2022
Last Verified
June 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CEP19-001
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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