- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04279080
LARS in Ovarian Cancer Patients
Low Anterior Resection Syndrome (LARS) in Ovarian Cancer Patients - a Multi-centre Comparative Analysis.
Background:
Low anterior resection syndrome (LARS) is a common functional disorder after low anterior resection impacting quality of life. Data on LARS derives nearly exclusively from rectal cancer studies. Therefore, the study was designed to assess LARS in advanced epithelial ovarian cancer (EOC) patients, who underwent rectal resection and to compare it with a female rectal cancer cohort.
Methods:
A cross-sectional multi-centre analysis was performed for female patients suffering from either rectal or EOC who received a low anterior resection as part of their therapy regimen. None of the patients received pre- or postoperative radiotherapy. LARS was defined by using the validated LARS score and its severity was divided into "no", "minor" and "major LARS".
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- low anterior resection because of ovarian or rectal cancer
Exclusion Criteria:
- neoadjuvant or adjuvant radiotherapy
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
1
rectal cancer patients
|
evaluation of postoperative functional bowel outcome
|
2
ovarian cancer patients
|
evaluation of postoperative functional bowel outcome
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
functional bowel outcome after low anterior resection
Time Frame: 1 year
|
low anterior resection syndrome score, questionnaire via telephone call or personal contact
|
1 year
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1201/2018
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Low Anterior Resection Syndrome
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Jewish General HospitalUniversity of Manitoba; McGill University Health Centre/Research Institute... and other collaboratorsRecruitingLow Anterior Resection Syndrome | Rectal Cancer | Surgery | Patient Activation | Low Anterior ResectionCanada, United States
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HEM Pharma Inc.Premier Research Group plcNot yet recruitingLARS - Low Anterior Resection Syndrome
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University Hospital, BordeauxTerminatedLow Anterior Resection Syndrome (LARS>20) | Refractory Medical Treatment After Rectal ResectionFrance
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Innovacion en Cirugía VigoRecruitingLow Anterior Resection Syndrome | Rectal Disorders | Low Anterior ResectionSpain
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National Cancer Institute, LithuaniaVilnius UniversityCompletedLow Anterior Resection SyndromeLithuania
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Ismail GögenurAarhus University Hospital; Hvidovre University HospitalActive, not recruitingLow Anterior Resection SyndromeDenmark
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Mirna Abraham-NordlingCompletedLow Anterior Resection SyndromeSweden
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Coloplast A/SMedPass InternationalCompleted
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Seoul National University HospitalRecruitingLARS - Low Anterior Resection SyndromeKorea, Republic of
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Ankara UniversityAarhus University Hospital; Dokuz Eylul University; Lokman Hekim ÜniversitesiCompletedLARS - Low Anterior Resection Syndrome
Clinical Trials on low anterior resection syndrome evaluation
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Russian Society of Colorectal SurgeonsCompleted
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National Cancer Institute, LithuaniaNational Cancer Institute (NCI); King's College LondonRecruitingLow Anterior Resection SyndromeLithuania
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First Affiliated Hospital of Zhejiang UniversityUnknownRectal NeoplasmsChina
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Immanuel Kant Baltic Federal UniversityCenter of Endourology "Endocenter"RecruitingColorectal Cancer | Rectal Cancer | Colon Cancer | Colorectal Adenocarcinoma | Rectal Adenocarcinoma | Colorectal Neoplasms MalignantRussian Federation
-
Slagelse HospitalZealand University Hospital; Association of Danish PhysiotherapistsWithdrawnQuality of Life | Low Anterior Resection Syndrome | Rectum Cancer | Faecal IncontinenceDenmark
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Osama Mohammad Ali ElDamshetyMansoura University; Marche Polytechnic university, Ancona, ItalyCompleted
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First Affiliated Hospital of Zhejiang UniversityCompletedRectal Neoplasms | Low Anterior ResectionChina
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Republican Clinical Oncological Dispensary, Ministry...RecruitingNeoplasms | Rectal Neoplasms | OstomyRussian Federation
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G. Hatzikosta General HospitalUniversity of IoanninaCompletedColorectal Cancer | Oxidative Stress | Colon Rectal ResectionGreece
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University of Roma La SapienzaUniversità Politecnica delle MarcheCompleted