Thorax Computed Tomography Severity Score and Outcome in COVID-19 Patients

June 8, 2020 updated by: Kazim Rollas, Tepecik Training and Research Hospital

Initial Thoracic CT Findings and Mechanical Ventilation Requirement in Patients Admitted to Intensive Care Unit With COVID-19

The most common thorax Computed tomography (CT) findings are multifocal ground-glass opacities and peripheral consolidation in patients with COVID-19. Septal thickening, bronchiectasis, pleural thickening, and subpleural involvement may also be observed. Although these findings are not specific to COVID-19, the severity of pulmonary involvement is expected to be correlated with thorax CT findings.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Thorax computed tomography severity score defined by Yang et al. can be used to evaluate the severity of pulmonary involvement in COVID-19 patients. We aimed to investigate whether the initial thorax computed tomography severity score can predict mechanical ventilation requirement and mortality in COVID-19 patients.

Study Type

Observational

Enrollment (Anticipated)

40

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
    • Izmir, Konak
      • Izmir, Izmir, Konak, Turkey, 35170
        • Recruiting
        • Tepecik Training and Research Hospital
        • Contact:
        • Contact:
        • Principal Investigator:
          • Işıl Köse Güldoğan
        • Sub-Investigator:
          • Yeliz Pekçevik
        • Sub-Investigator:
          • Naciye Sinem GEZER
        • Sub-Investigator:
          • Kazım Rollas
        • Sub-Investigator:
          • Çiler Zincircioğlu
        • Sub-Investigator:
          • Uğur Uzun
        • Sub-Investigator:
          • İsa Sahar
        • Sub-Investigator:
          • Taner Çalışkan
        • Sub-Investigator:
          • Aykut Sarıtaş
        • Sub-Investigator:
          • Nimet Şenoğlu

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patient admitted to the intensive care unit with COVID-19 pneumonia confirmed by RT-PCR

Description

Inclusion Criteria:

  • Age ≥ 18 years
  • COVID-19 confirmed by positive RT-PCR and/or antibody testing
  • CT scan at intensive care unit admission

Exclusion Criteria:

  • Loss of CT data
  • Chronic lung disease findings by CT that may lead to misinterpretation
  • RT-PCR results unavailable or negative
  • Terminal cancer

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Retrospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
COVID-19 patients
Patient tested positive for COVID-19 who had a CT scan
Diagnostic test: CT-Scan
Chest CT scan on admission to the intensive care unit

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Invasive respiratory support in patients with COVID-19
Time Frame: 120 days
Whether Thorax CT findings predict invasive mechanical ventilation requirement of covid-19 patients
120 days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mortality in patients with COVID-19
Time Frame: 120 days
Whether Thorax CT findings predict mortality of covid-19 patients
120 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tepecik Training and Research Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 15, 2020

Primary Completion (Anticipated)

June 15, 2020

Study Completion (Anticipated)

July 15, 2020

Study Registration Dates

First Submitted

June 8, 2020

First Submitted That Met QC Criteria

June 8, 2020

First Posted (Actual)

June 11, 2020

Study Record Updates

Last Update Posted (Actual)

June 11, 2020

Last Update Submitted That Met QC Criteria

June 8, 2020

Last Verified

June 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2020/5-4

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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