- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04478097
Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics in Healthy Volunteers
July 20, 2020 updated by: Chong Kun Dang Pharmaceutical
A Randomized, Open, Single-dose, 3 Period Partial Replicated Crossover-design Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics After Administration of CKD-333 or Co-administration of CKD-330 and D086 in Healthy Volunteers Under Fasting Conditions
This study is a randomized, open, single-dose, 3 period partial replicated crossover-design study to investigate the pharmacokinetic profiles and safety of CKD-333 in healthy volunteers.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
To healthy subjects of fifty-one (51), following treatments are administered dosing in each period and wash-out period is a minimum of 14 days.
Study Type
Interventional
Enrollment (Anticipated)
51
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Daejeon, Korea, Republic of
- Jang Hee Hong
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
19 years to 54 years (ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Healthy adults over the age of 19 years and under the age of 55 years at the time of screening
Individuals who had 17.5 kg/m2 ≤ Body Mass Index(BMI) < 30.5kg/m2 and men's total body weight ≥ 55 kg, women's total body weight ≥ 45 kg
* BMI = Weight(kg)/ Height(m)2
- Individuals without congenital/chronic diseases and without abnormal symptoms or diagnosis based on a medical examination within the last 3 years
- Individuals who were deemed to be appropriate as study subjects following laboratory tests (hematology, blood chemistry, urinalysis, viral/bacterial, etc.) and vital signs, ECG etc. performed at screening
- Individuals who signed an informed consent form and decided to participate in the study after being fully informed of the study prior to participation
- Individuals who agreed proper contraception during the study and did consent to not donation of sperm 1 month after the last dose of study drug infusion
- Individuals with the ability and willingness to participate the entire study period
Exclusion Criteria:
- Individuals with a medical evidence or a history of clinically significant hepatobiliary, renal, neurologic, respiratory, digestive, endocrine, blood-oncology, urinary, cardiovascular, musculoskeletal or psychiatric
- Individuals with a medical history of gastrointestinal disease (e.g., Crohn's disease and ulcer) or gastrectomy (excluding simple appendectomy or herniotomy) that may affect drug absorption
Individuals with the following results at screening test:
- ALT or AST > 2x the upper limit of the normal range
- Creatinine > upper limit of the normal range or eGFR with MDRD <60 ml/min/1.73 m2
- ECG Result, QTc > 450msec
- CPK > UNL(upper normal limit) x 3.0
- K > 5.5mEq/l
- Hct < lower limit of the normal range
- A history of regular alcohol consumption exceeding 21 units/week within the 3 months(1 unit = 10 g = 12.5 ml) prior to screening or individuals who cannot quit drinking from 48hr prior to the first dose to end of last blooding (1 drink (250 mL) of beer (5%) = 10 g; 1 drink (50 mL) of hard liquor (20%) = 8 g; 1 drink (125 mL) of wine (12%) = 12 g)
- Individuals who smoked more than 20 cigarettes per day within 6 months prior to screening or cannot quit smoking during hospitalization period
- Individuals who had been administered investigational product(s) of other clinical study or bioequivalence study within the 6 months prior to the first dose of this study
Following vital signs results at screening
- Sitting systolic blood pressure ≥ 140 mmHg or < 90 mmHg
- sitting diastolic blood pressure ≥90 mmHg or <60 mmHg
- Individuals with a medical history of significant drug abuse within one year prior to the screening or positive for abuse drug in urine test results at screening
- Individuals taking medication known to significantly induce or inhibit drug metabolizing enzymes within 30days before the first administration of clinical trial drug
- Individuals who had taken prescription or nonprescription drugs within the 10 days prior to the first dose of investigational product(s)
- Individuals who donated whole blood within the 2 months, or blood components within 1 month prior to the first dose of the investigational product(s)
- Individuals with hypersensitivity to investigational products or the investigational products ingredients
Patients or conditions deemed to be at risk for using investigational products
- Patient with hyperkalemia
- Patients with hepatopathy
- Patients with hereditary angioedema, ACE inhibitors or angiotensin 2 receptor antagonists who have a history of angioedema
- Primary hyperaldosteronism
- Patients with aortic valve stenosis, mitral (valve) stenosis, hypertrophic obstructive cardiomyopathy
- Patients with ischemic heart disease, ischemic cardiovascular disease, cerebrovascular disease
- Patients with Intravascular volume depletion
- Patients with diabetes or kidney failure
- Patients with renal artery stenosis
- Patients with muscle disease
- Patients with Hypothyroidism
- Patients with a history of muscle toxicity when using statins or fibrates
- Patients who have recently had a kidney transplant
- Patients with history of shock
- Individuals with hereditary diseases of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption etc.
- Individuals who drunk grapefruit juice or caffeine more than 5 cup per day within 3 months prior to screening or cannot quit drinking during clinical trials period
- Individuals who cannot eat standard meal in institution
- Women who are pregnant or may be pregnant
- Individuals who were deemed to be inappropriate to participate in the study by the investigator
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: CROSSOVER
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Reference-Reference-Test
|
1T
Other Names:
1T
Other Names:
|
EXPERIMENTAL: Reference-Test-Reference
|
1T
Other Names:
1T
Other Names:
|
EXPERIMENTAL: Test-Reference-Reference
|
1T
Other Names:
1T
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
AUCt of CKD-330, D086, CKD-333
Time Frame: [Time Frame: Pre-dose (0 hour), post-dose 0.17, 0.33, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 48, 72 hours]
|
Area under the CKD-330/D086/CKD-333 concentration in blood-time curve from zero to final
|
[Time Frame: Pre-dose (0 hour), post-dose 0.17, 0.33, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 48, 72 hours]
|
Cmax of CKD-330, D086, CKD-333
Time Frame: [Time Frame: Pre-dose (0 hour), post-dose 0.17, 0.33, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 48, 72 hours]
|
The maximum CKD-330/D086/CKD-333 concentration in blood sampling time t
|
[Time Frame: Pre-dose (0 hour), post-dose 0.17, 0.33, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 48, 72 hours]
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ANTICIPATED)
July 14, 2020
Primary Completion (ANTICIPATED)
November 5, 2020
Study Completion (ANTICIPATED)
January 1, 2021
Study Registration Dates
First Submitted
July 17, 2020
First Submitted That Met QC Criteria
July 17, 2020
First Posted (ACTUAL)
July 20, 2020
Study Record Updates
Last Update Posted (ACTUAL)
July 22, 2020
Last Update Submitted That Met QC Criteria
July 20, 2020
Last Verified
July 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- A70_09BE2005
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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