International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry

May 4, 2026 updated by: SCAD Alliance

The International Spontaneous Coronary Artery Dissection "iSCAD" Registry (SCAD)

The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD.

The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its recurrence. This observational study will be prospective and retrospective in its recruitment and will collect clinical information to better understand the natural history and prognosis for SCAD.

Study Overview

Status

Active, not recruiting

Conditions

Detailed Description

Spontaneous Coronary Artery Dissection (SCAD) is an under-diagnosed cause of acute coronary syndrome (ACS), myocardial infarction (MI) and sudden cardiac arrest. The inner lining of the coronary artery splits and allows blood to seep into the adjacent layer, forming a blockage (hematoma), or the artery continues to tear, creating a flap of tissue that blocks blood flow in the artery.

SCAD strikes generally healthy, younger individuals (average age 42) who do not have traditional cardiac risk factors. Warning signs of SCAD encompass the full range of ACS and MI symptoms, from vague to classic. The cause of SCAD is currently unknown and the psychosocial impact of SCAD is traumatizing. The work of the iSCAD Registry will encompass the physical and psychosocial study of SCAD.

Study Type

Observational

Enrollment (Actual)

2000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Australia
    • New South Wales
      • Darlinghurst, New South Wales, Australia, NSW 2010
        • Victor Chang Cardiac Research Institute
  • United States
    • California
      • Los Angeles, California, United States, 90048
        • Cedars Sinai
      • Los Angeles, California, United States, 93003
        • UCLA (University of California, Los Angeles)
      • San Francisco, California, United States, 94115
        • Kaiser Permanente Northern California
    • Colorado
      • Aurora, Colorado, United States, 80045
        • University of Colorado
    • Connecticut
      • Hartford, Connecticut, United States, 06106
        • Hartford Hospital
    • Florida
      • Tampa, Florida, United States, 33602
        • University of South Florida
    • Georgia
      • Atlanta, Georgia, United States, 30308
        • Emory Healthcare System
    • Illinois
      • Chicago, Illinois, United States, 60611
        • Northwestern Medicine
    • Kentucky
      • Lexington, Kentucky, United States, 40508
        • University Of Kentucky
    • Maryland
      • Baltimore, Maryland, United States, 21224
        • Johns Hopkins
    • Massachusetts
      • Boston, Massachusetts, United States, 02114-2696
        • Massachusetts General Hospital
    • Missouri
      • Kansas City, Missouri, United States, 64111
        • St. Luke's Mid America
      • St Louis, Missouri, United States, 63110
        • Washington University
    • New Hampshire
      • Lebanon, New Hampshire, United States, 03756
        • Dartmouth-Hitchcock
      • Manchester, New Hampshire, United States, 03102
        • Catholic Medical Center
    • New York
      • New York, New York, United States, 10032
        • Columbia University Medical Center
      • New York, New York, United States, 10029-6574
        • Mount Sinai
    • North Carolina
      • Charlotte, North Carolina, United States, 28204
        • Atrium Health Sanger Heart and Vascular Institute
    • Ohio
      • Cleveland, Ohio, United States, 44106
        • University Hospitals--Case Western
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73120
        • Oklahoma Heart
    • Oregon
      • Portland, Oregon, United States, 97225
        • Providence
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19104
        • University of Pennsylvania
      • Pittsburgh, Pennsylvania, United States, 15213
        • University of Pittsburgh Medical Center
      • Pittsburgh, Pennsylvania, United States, 15212
        • Allegheny General Hospital, Allegheny Health Network
    • Tennessee
      • Nashville, Tennessee, United States, 37232
        • Vanderbilt University Medical Center
    • Texas
      • Dallas, Texas, United States, 75390
        • UT Southwestern
    • Utah
      • Murray, Utah, United States, 84107
        • Intermountain
    • Virginia
      • Charlottesville, Virginia, United States, 22908
        • University of Virginia
      • Fairfax, Virginia, United States, 22031
        • Inova Heart & Vascular Institute
    • Washington
      • Seattle, Washington, United States, 98195
        • University of Washington Medicine

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Spontaneous coronary artery dissection (SCAD) is defined as the non-traumatic, non-iatrogenic separation of the coronary arterial wall by intramural hemorrhage creating a false lumen, with or without an intimal tear. SCAD nearly always presents as an acute myocardial infarction. The prevalence of SCAD varies depending on the population studied. A goal of iSCAD Registry is to expand diversity of race, ethnicity, and sex of study participants. The mean age of SCAD presentation is 45-53 years of age, and appears to primarily affect women.

Description

Inclusion Criteria:

Participants with a new diagnosis of SCAD or a history of confirmed or suspected SCAD will be prospectively recruited from either:

  1. Inpatient wards of the enrolling medical centers during the acute presentation of SCAD, or
  2. Outpatient cardiovascular clinics of enrolling medical centers.

Participants must be:

  • 18 years of age or older
  • Diagnosis of SCAD or history of SCAD based on coronary angiography, either catheter-based or coronary CTA
  • Suspected SCAD by coronary angiography

Exclusion Criteria:

  1. Coronary dissection in association with atherosclerosis or as a result of iatrogenic injury
  2. Inability to provide informed consent
  3. Inability to complete study-related patient questionnaires
  4. Inability to understand and complete patient questionnaires independently

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Other

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Descriptive Data
Time Frame: Continuous time frame following index event for an average of 3 years from study contact date
Participant demographic, historical, clinical characteristics, and treatment data
Continuous time frame following index event for an average of 3 years from study contact date
Clinical Outcomes
Time Frame: Continuous time frame following index event for an average of 3 years from study contact date
Prospectively collected long-term outcomes including recurrent myocardial infarction, hospitalization, heart failure, stroke or transient ischemic attack, arrhythmia, and all cause mortality
Continuous time frame following index event for an average of 3 years from study contact date
Psychosocial Outcomes
Time Frame: Continuous time frame following index event for an average of 3 years from study contact date
Prospectively collected data on participant's mental health using validated questionnaires
Continuous time frame following index event for an average of 3 years from study contact date

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

SCAD Alliance

Collaborators

PERFUSE Study Group

Investigators

  • Study Chair: Esther Kim, MD, Chair, Steering Committee
  • Principal Investigator: Malissa Wood, MD, Member, Steering Committee
  • Principal Investigator: Sahar Naderi, MD, Member, Steering Committee

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 8, 2019

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Study Registration Dates

First Submitted

July 29, 2020

First Submitted That Met QC Criteria

July 29, 2020

First Posted (Actual)

August 3, 2020

Study Record Updates

Last Update Posted (Actual)

May 6, 2026

Last Update Submitted That Met QC Criteria

May 4, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 20190308

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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