- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04519762
Levels of 'Hypophosphatemia Affect Outcome of Septic Patients in ICU
Hupophosphatemia Levels Deleteriously Affect Outcome of Patients With Severe Sepsis/Septic Shock Admitted to ICU
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The study will include all patients admitted to ICU with or developing severe sepsis or septic shock within 24-hr after admission to ICU. Patients will be categorized according to at-admission inorganic phosphate (Pi) level into normophosphatemia group and hypophosphatemia group (HP) (mild, moderate and severe HP). All patients will be evaluated using Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II score (APACHE II) and blood samples will be collected for ELISA estimation of serum Pi, human C-reactive protein (CRP), L-lactate, CBC picture , serum electrolytes and kidney and liver function tests. Serum Pi level will be re-estimated immediately and 24-hr after full dose administration. Outcomes will include the 28-day ICU morbidity and mortality rates and their relation to HP severity and PST administration.
Patients who will fulfill the inclusion criteria will be selectively divided into two groups according to estimated level of serum Pi: Control group will include patients with serum Pi >2.5 mg/dl and Study group will include patients having serum Pi<2.5 mg/dl and will be further sub-grouped according to severity of HP into mild HP (2-2.5 mg/dl), moderate (1-1.9 mg/dl) or severe (<1 mg/dl).
Central venous catheter will be inserted for all patients enrolled in the study via the jugular or subclavian vein. Then, baseline hemodynamic parameters and central venous pressure (CVP) will be estimated and will be continuously monitored. Arterial blood samples will be obtained anaerobically and collected in heparinized tubes for estimation of arterial blood gas and pH.
Sepsis management: Patients were managed according to guidelines of Surviving
Sepsis Campaign; briefly:
- Fluid therapy
- Vasoactive drug therapy
- Intropics
- Antibiotic therapy
HP management regimen follows:
- Calculation of supplementation dose according to the equation: phosphate dose (in mmol) = 0.5 x body weight x (1.25 - [serum Pi]).
- Preparation that will be used: Glycophos®, Fresenius Kabi Egypt (organic phosphate solution 1mmol/ml). Vial 20 ml (1ml contains 1mmol of phosphate and 2mmol of sodium).
- Dilution: will be diluted prior to parenteral administration. 20 ml of sodium-glycerophosphate diluted in 30 cc of dextrose 5% administered by syringe pump (50 mL).
- The total calculated dose will be divided into three doses every 8 hours.
Study Type
Enrollment (Anticipated)
Phase
- Phase 4
Contacts and Locations
Study Contact
- Name: Noha Hussien, Dr.
- Phone Number: +201222830981
- Email: nohasayedhussien@gmail.com
Study Contact Backup
- Name: Sherif Anis, Dr.
- Phone Number: +2001222421674
- Email: sherifganis@hotmail.com
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- patients with severe sepsis and/or septic shock within 24 hours of admission to ICU
Exclusion Criteria:
- children and adulthoods younger than 18 years
- pregnancy
- severe hemorrhagic shock
- maintenance on immunosuppressant therapy for any indication
- patients who are expected to die within the first 24 hours after admission
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Sham Comparator: Control group
Management of sepsis/ septic shock via fluids, antibiotics, vasopressors and inotropes.
|
Management of severe sepsis/septic shock via fluid therapy, antibiotics, vasopressors and inotropics.
Other Names:
Management of severe sepsis/septic shock via fluid therapy, antibiotics, vasopressors and inotropics.
Other Names:
|
Active Comparator: Study group
Management of sepsis/ septic shock in addition to management of hypophosphatemia.
|
Management of severe sepsis/septic shock via fluid therapy, antibiotics, vasopressors and inotropics.
Other Names:
Management of severe sepsis/septic shock via fluid therapy, antibiotics, vasopressors and inotropics.
Other Names:
Management of hypophosphatemia via Glycophos Management of severe sepsis/septic shock via fluid therapy, antibiotics, vasopressors and inotropics.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Mortality (No.)
Time Frame: 15 September 2020 - 15 December 2020 (3 months)
|
Assessment of mortality Assessment of mortality
|
15 September 2020 - 15 December 2020 (3 months)
|
Mortality (%)
Time Frame: 15 September 2020 - 15 December 2020 (3 months)
|
Assessment of mortality
|
15 September 2020 - 15 December 2020 (3 months)
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Ahmed Kamal, Dr., Ain Shams University
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- R38/2020
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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