A Study on Hemodynamic Relationship Including Cerebral Blood Flow Using Phase Contrast and Signal Intensity Gradient of Brain Magnetic Resonance Imaging, and Carotid Doppler Ultrasound

A Study on Hemodynamic Relationship Including Cerebral Blood Flow Using Phase Contrast and Signal Intensity Gradient of Brain Magnetic Resonance Imaging, and Carotid Doppler Ultrasound

Sponsors

Lead Sponsor: Chonbuk National University Hospital

Collaborator: Medi Image, Inc

Source Chonbuk National University Hospital
Brief Summary

Cerebral blood flow measurement, which is applied to patients with cerebrovascular-related diseases, provides useful information about hemodynamic status. There was a method using Doppler ultrasound and phase contrast (PC) MRI, but it was not widely used in clinical practice due to limitations in reproducibility between examiners, complexity of procedure, and time-intensive protocol. We intend to measure cerebral blood flow through the signal-intensity gradient (SIG) technique using Time-of-Flight (TOF) of brain magnetic resonance imaging, which can compensate for the shortcomings of the existing research methods. In addition, by analyzing the correlation with the previous methods, Doppler ultrasound and PC MRI, we will evaluate the effectiveness of our new method.

Overall Status Recruiting
Start Date September 3, 2020
Completion Date January 31, 2021
Primary Completion Date January 31, 2021
Study Type Observational
Primary Outcome
Measure Time Frame
Cerebral blood flow correlation After completion of recruitment, average 1 year
Enrollment 30
Condition
Intervention

Intervention Type: Diagnostic Test

Intervention Name: Signal intensity gradient

Description: Signal intensity gradient: In time-of-flight (TOF) MRA, The signal intensities at the iso-point (Φa; signal intensity at position A [Xa] along the arterial contour line) and at the inner point (Φb; signal intensity at position B [Xb]) were calculated by using a trilinear interpolation algorithm based on the positions and signal intensities in the eight neighboring voxels. The signal intensities of TOF-MRA were normalized to eliminate the offset and scale effects across the MRA datasets of participants. For each iso-point (position A), the SIG was calculated from the difference in signal intensities between points A and B as follows: Scalar SIG, SI/mm = (Φb - Φa) / │Xb - Xa│ (1) Vector SIG, SI/mm = (Φb - Φa) n / │Xb - Xa│ (2)

Arm Group Label: Subjects

Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria: 1. Patients 18 years of age or older who have been admitted to the neurology department due to a stroke, and those who have already performed brain magnetic resonance imaging 2. Among the patients (1) who underwent carotid artery Doppler ultrasound 3. Patients who fully understand the research objectives and procedures and wish to participate in clinical research voluntarily 4. If a patient is not fully understood due to a decrease in awareness or consciousness, the consent of the legal representative is required Exclusion Criteria: 1. Patients whose extracranial artery occlusion or severe stenosis was confirmed in brain magnetic resonance images. 2. Those who judge that the subject is unsuitable for participation in clinical research due to other reasons.

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Chan-Hyuk Lee, Prof. Principal Investigator Jeonbuk National University Hospital
Overall Contact

Last Name: Chan-Hyuk Lee, Prof.

Phone: +82-063-250-1590

Email: [email protected]

Location
Facility: Status: Contact: Jeonbuk National University Hospital Chan-Hyuk Lee, Prof. +82-010-2822-9803 [email protected]
Location Countries

Korea, Republic of

Verification Date

October 2020

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Chonbuk National University Hospital

Investigator Full Name: Chan-Hyuk Lee

Investigator Title: Professor

Keywords
Has Expanded Access No
Arm Group

Label: Subjects

Description: Cerebral blood flow of a subject is measured using three methods in both common carotid and vertebral arteries. 1) Phase-contrast MR 2) Doppler sonography 3) Signal Intensity Gradient (SIG) To determine whether there is a correlation between the measured values, the correlation coefficient is calculated and analyzed.

Patient Data No
Study Design Info

Observational Model: Case-Only

Time Perspective: Prospective

Source: ClinicalTrials.gov