- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04719091
CLINICAL EVALUATION OF THE EFFICACY OF AN INTRA ORAL SPRAY FOR PATIENTS WITH XEROSTOMIA
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Have provided written informed consent prior to being entered into the study.
- Must be at least 18 years of age, male or female.
- Have at least 12 natural or restored teeth.
- Have a negative history of radiation therapy to head and neck
- Have a complaint of xerostomia
- Have an unstimulated salivary flow rate <0.25ml/minute which represents 35-50% of normal salivary function
- Agree not to have a dental prophylaxis or any other elective, non-emergency dental procedures (other than those provided during the study) any time during the study.
- Agree to abstain from the use of any products for xerostomia other than those provided in the study.
- Agree to comply with the conditions and schedule of the study.
Exclusion Criteria:
- Physical limitations or restrictions that might preclude normal tooth brushing.
- Evidence of gross oral pathology, including widespread caries or chronic neglect, extensive restoration, pre-existing gross plaque or soft or hard tissue tumor of the oral cavity.
- Presence of severe gingivitis with 30 or more sites showing bleeding on probing.
- Evidence of major oral hard or soft tissue lesions or trauma at the baseline visit as determined by the Investigator/Examiner.
- Chronic disease with concomitant oral manifestations other than xerostomia
- Conditions requiring antibiotic treatment prior to dental prophylaxis and invasive procedures, such as heart murmur, history of rheumatic fever, valvular disease or certain prosthetic implants.
- History of uncontrolled diabetes or hepatic or renal disease, or other serious conditions or transmittable diseases, (e.g. cardiovascular disease, AIDS).
- Subjects who are currently undergoing, or require, extensive dental work or orthodontic treatment.
- Currently using bleaching trays.
- History of significant adverse effects following use of oral hygiene products such as toothpastes and mouth sprays.
- Subjects who are nursing, pregnant or plan to become pregnant for the duration of the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: HA formulation Oral Spray
The Study Examiner and staff will screen for subjects that meet the enrollment criteria.
Subjects will be randomly assigned to one of two treatment groups.
Oral soft and hard tissue examinations will be conducted at each visit.
Following an initial 3-5 minute evaluation of resting salivary flow, subjects will wait 10 minutes and then use their assigned spray.
They will then swallow, and unstimulated saliva will be collected for 3-5 minutes.
They will then remain in the study center for 60 min to evaluate xerostomia relief by questionnaire at 5, 15, 30, 45 and 60 min.
after the use of Experimental mouth spray.
They will then be given their assigned product to use twice daily for one week
|
Oral spray
|
Placebo Comparator: Placebo Oral Spray
The Study Examiner and staff will screen for subjects that meet the enrollment criteria.
Subjects will be randomly assigned to one of two treatment groups.
Oral soft and hard tissue examinations will be conducted at each visit.
Following an initial 3-5 minute evaluation of resting salivary flow, subjects will wait 10 minutes and then use their assigned spray.
They will then swallow, and unstimulated saliva will be collected for 3-5 minutes.
They will then remain in the study center for 60 min to evaluate xerostomia relief by questionnaire at 5, 15, 30, 45 and 60 min.
after the use of placebo mouth spray.
They will then be given their assigned product to use twice daily for one week
|
Oral spray
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Relief from dry mouth using VAS scoring
Time Frame: 3 weeks
|
At end of each treatment week they will be asked to answer the following VAS question How well did this product make your mouth feel moist? At end of each treatment week they will be asked to answer the following VAS question At the end of the study they will be asked: How would you rate the second mouthspray compared to the first Study mouthspray in terms of your mouth feeling moist? |
3 weeks
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- LUX-101-15
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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