Analysis of Motor Skills in Subjects Aged 55 and Over: the Role of Cognitive Abilities for Planning Movement. (Vieillissement)

September 17, 2025 updated by: Centre Hospitalier Universitaire Dijon
Falling is an event that is more frequent and severe in older age. It can lead to a loss of autonomy and a decrease in quality of life. It is therefore important to understand this phenomenon in order to better prevent it. Among the multiple risk factors associated with falling, recent research has shown a link between the decline in cognitive abilities (i.e., the mental processes that form our knowledge, such as memory) and the risk of falling. However, the impact of this cognitive decline on motor skills is still poorly understood. The purpose of this research is to study how the changes induced by aging affect motor skills. This would make it possible to take a new look at the phenomenon of falls occurring in the elderly and, in the long term, to improve the prevention and rehabilitation.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

684

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

young subjects, elderly neurotypical subjects and elderly subjects with mild cognitive disorder

Description

Inclusion Criteria:

  1. Neurotypical subjects group:

    • Person aged 18 to 40 years
    • Person who has given oral consent
    • Affiliated to national health insurance
    • Right-handed person

  2. Group of elderly neurotypical subjects:

    • Person over 55 years of age
    • Person who has given oral consent
    • Affiliated to national health insurance
    • No cognitive problems (MMSE score >26)
    • Right-handed person

  3. Elderly mild cognitive disorder subject group:

    • Person over 55 years of age
    • Person who has given oral consent
    • Diagnosis of Mild Cognitive Disorder made by a neurologist at the Centre Mémoire Ressources et Recherche (CMRR) of the University Hospital of Dijon, following the recommendations of the National Institute for Aging and Alzheimer's Association (Albert et al., 2011) This diagnosis is based on psychometric tests, brain imaging and the evolution of cognitive disorders, including an MMSE test.
    • Right-handed person

Exclusion Criteria:

  • Neurological or psychiatric history with the exception of the TCL group.
  • Follow-up of drug treatment in the last three months that may affect cognitive and/or motor skills.
  • Received a shoulder prosthesis on the dominant side.
  • Received a hip and/or knee replacement less than a year ago.
  • Disabling joint disease of the hip or knee shoulder
  • Protected adults (curatorship, guardianship)
  • Person deprived of their liberty b judicial or administrative decision
  • Pregnant, parturient or breastfeeding woman
  • Major unable to consent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Control
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
young neurotypical subjects
people from 18 to 40 years old
Other: Sequence 1
perform arm movements towards a target
Other: Sequence 2
judge the verticality of an object
Other: Sequence 3
In standing position, point as quickly as possible with the right arm at the diode that will light up in front of the participant.
elderly neurotypical subjects
people over 55 years of age
Other: Sequence 1
perform arm movements towards a target
Other: Sequence 2
judge the verticality of an object
Other: Sequence 3
In standing position, point as quickly as possible with the right arm at the diode that will light up in front of the participant.
Elderly subjects with mild cognitive impairment
people over 55 years of age, with a diagnosis of mild cognitive impairment
Other: Sequence 1
perform arm movements towards a target
Other: Sequence 2
judge the verticality of an object
Other: Sequence 3
In standing position, point as quickly as possible with the right arm at the diode that will light up in front of the participant.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Sequence 1: symmetry ratio of the finger speed profile
Time Frame: through study completion, an average of 3 years
through study completion, an average of 3 years
Sequence 2 : perception bias (error in degrees of angle) of dynamic subjective visual vericality
Time Frame: through study completion, an average of 3 years
through study completion, an average of 3 years
Sequence 3 : activation time of the focal muscles in relation to the postural muscles
Time Frame: through study completion, an average of 3 years
through study completion, an average of 3 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire Dijon

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 25, 2021

Primary Completion (Estimated)

December 1, 2028

Study Completion (Estimated)

December 1, 2028

Study Registration Dates

First Submitted

October 6, 2020

First Submitted That Met QC Criteria

February 11, 2021

First Posted (Actual)

February 15, 2021

Study Record Updates

Last Update Posted (Estimated)

September 22, 2025

Last Update Submitted That Met QC Criteria

September 17, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MANCKOUNDIA 2018

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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