Carotid Asymptomatic Stenosis (CARAS)

Natural History of Asymptomatic Carotid Artery Stenosis in the Modern Era

There is debate on the natural history of asymptomatic severe carotid artery stenosis. Previous studies conducted more than 20 years ago revealed the benefit of carotid endarterectomy compared with medical therapy only on the stroke prevention. However, today it seems that the current medical regimen can reduce the cerebral ischemic event rate in patients with asymptomatic severe carotid artery stenosis to less than 1% per year, making it questionable to choose the surgical treatment.

Study Overview

• Status: Active, not recruiting
• Conditions: Asymptomatic Carotid Artery Stenosis
• Intervention / Treatment: Diagnostic test: duplex ultrasound and computed tomography angiography

Detailed Description

The Primary end point is to evaluate the rate of cerebral ischemic events (stroke or transient ischemic attack) in patients with asymptomatic carotid artery stenosis > 60% (Nascet criteria) in a 5-year follow-up period. It is a prospective observational study conducted on patients enrolled from January 2019 to March 2020 and with the end of follow-up scheduled in 2025.

The medical therapy recommended includes antihypertensive drugs to maintain good blood pressure control, statin therapy and antiplatelet administration.

Secondary end points are the evaluation of plaque progression, the identification of comorbidities or plaque characteristics associated with a higher risk for cerebral ischemic events and the patient adherence to the best medical therapy in a real world scenario. The global survival and the factors influencing survival will be investigated as well.

Separate analyses are performed for patients with total carotid occlusion or carotid artery re-stenosis.

Patient's cohort: with the hypothesis of 3 neurologic (transient ischemic attack or stroke) events per 100 patients/year during a 5 years follow-up period and consequently a number of 40-50 events (primary outcome), the study cohort with a native asymptomatic carotid artery stenosis will include at least 300 patients. Patients with carotid occlusion or restenosis are evaluated separately for a secondary analysis only.

Patients are prospectively identified and enrolled in a single center vascular surgery ambulatory and a duplex ultrasonography (DUS) laboratory. Carotid artery stenosis are identified and the degree of stenosis >60% (NASCET criteria) is evaluated according to the current guidelines for stenosis identification through blood flow velocities. Patients enrollment goes from January 2019 to March 2020. The investigators prospectively complete the dedicated database including clinical characteristics, cardiovascular risk factors, medical therapy in use, features of the carotid plaque and contralateral carotid status.

Clinical characteristics included in the database: age, sex, hypertension (systolic blood pressure ≥140 or/and diastolic ≥90 mmHg, or specific therapy), dyslipidemia (total cholesterol ≥200 mg/dl or low density lipoprotein ≥120 mg/dl or specific therapy), diabetes mellitus (pre-diagnosed, in therapy with oral hypoglycemic drugs or insulin), current smoking, coronary artery disease (defined as a history of angina pectoris, myocardial infarction or coronary revascularization), chronic obstructive pulmonary disease (defined as chronic bronchitis or emphysema), chronic kidney disease (glomerular filtration rate <60 ml/min), contralateral carotid occlusion, stenosis and atrial fibrillation (paroxysmal or permanent).

Medical therapy: antiplatelet types, anticoagulant therapy, statin therapy, anti hypertensive medical therapy.

Carotid plaque characteristics for the analysis: degree of stenosis (flow measurement analysis), plaque ulcerations and echoluncency.

The follow-up consists of a telephone interview any six months and an annual clinical and duplex examination until a 5-years follow-up is reached or the patient withdraws from the study.

Patients that will be enrolled will sign specific consents. Sensitive patient information will not be available during data analysis. The clinical study will be carried out according to the ethical principles of the Declaration of Helsinki and following the active regulations on observational studies.

Patients who underwent a transient ischemic attach or a stroke within the 6-months before the enrollment are excluded from the study. Any neurological symptom occurred during the follow-up needs to be certified by an in hospital neurologist physical examination.

Statistical analysis: Continuous variables were described with mean and standard deviation. Continuous variables were compared by unpaired Student' t test in case of normal distribution, otherwise by Mann-Whitney's test. The differences between percentages were assessed using Fisher's test or Chi-square test, when appropriate. Univariate analysis will be performed by Kaplan Meier analysis (log-rank test) and single factor Cox analysis . Multivariate analyses with Cox analysis will be performed including factors considered statistical significant (P value ≤ .05) at the univariate analyses. Risk factors were reported as hazard ratio (HR) and 95% of confidence interval (CI). A value of p ≤ .05 (two-tailed) was considered to be significant. The statistical tests were performed using SPSS® 21.0 for Windows® (SPSS, Chicago, Il, USA).

• Study Type: Observational
• Enrollment (Anticipated): 300

Contacts and Locations

Study Locations

• Italy
  • Bologna, Italy, 40138
    • Policlinico S. Orsola Malpighi

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients are prospectively identified and enrolled in a single center vascular surgery ambulatory and a duplex ultrasonography (DUS) laboratory. Carotid artery stenosis are identified and the degree of stenosis >60% is evaluated according to the current guidelines for stenosis identification through blood flow velocities. Patients enrollment goes from January 2019 to March 2020. The investigators prospectively complete the dedicated database including clinical characteristics, cardiovascular risk factors, medical therapy in use, features of the carotid plaque and contralateral carotid status.

Description

Inclusion Criteria:

- asymptomatic carotid artery stenosis (according to the ESVS guidelines) >60% (NASCET criteria) with a physical examination and a DUS at the S. Orsola Malpighi hospital from 2019 to 2025.

Exclusion Criteria:

• Patients submitted to carotid revascularization will be included until the revascularization.
• Patients who underwent a transient ischemic attach or a stroke within the 6-months before the enrollment are excluded from the study
• Restenosis
• Carotid total occlusion

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cerebral ischemic events	Stroke and transient cerebral ischemic events or amaurosis fugax, evaluated by clinical neurologist by clinical examination (National Institutes of Health Stroke Scale, NIHSS or modified Rankin scale, mRS)	5 years
Ipsilateral cerebral ischemic events	Ipsilateral stroke and transient cerebral ischemic events or amaurosis fugax, evaluated by clinical neurologist by clinical examination (National Institutes of Health Stroke Scale, NIHSS or modified Rankin scale, mRS)	5 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Plaque progression	Increasing of carotid stenosis from 60%-79% to >80% according with duplex ultrasound flow measurement (Nascent criteria)	5 years
Patient's adherence to the medical therapy	adherence to medical drugs prescribed	5 years
Survival	Survival rate	5 years

Collaborators and Investigators

• Sponsor: University of Bologna

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2019
• Primary Completion (Actual): January 1, 2021
• Study Completion (Anticipated): January 1, 2025

Study Registration Dates

• First Submitted: March 26, 2021
• First Submitted That Met QC Criteria: March 30, 2021
• First Posted (Actual): April 1, 2021

Study Record Updates

• Last Update Posted (Actual): April 1, 2021
• Last Update Submitted That Met QC Criteria: March 30, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Arterial Occlusive Diseases; Pathological Conditions, Anatomical; Carotid Artery Diseases; Carotid Stenosis; Constriction, Pathologic
• Other Study ID Numbers: STECA

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No