Topical Agents Containing Magnesium Sulfate & Wound Healing in the Rat Model

May 10, 2021 updated by: Basaksehir Cam & Sakura Şehir Hospital

The Effect of Topical Agents in Cream Formations Containing Magnesium Sulfate on Wound Healing in the Rat Model

An experimental study examining wound healing in 5 different groups on 30 rats.

Study Overview

Status

Enrolling by invitation

Conditions

Intervention / Treatment

Detailed Description

Magnesium topically increases collagen synthesis and angiogenesis, providing faster and higher quality wound healing. In addition, with its analgesic effect, it will also eliminate the pain sensation caused by the wound and increase the quality of life of the patient whose skin integrity is impaired.

Study Type

Interventional

Enrollment (Anticipated)

30

Phase

  • Early Phase 1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Istanbul, Turkey
        • Başakşehir Çam Ve Sakura Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

1 month to 2 months (Child)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Female

Description

Inclusion Criteria:

  • healthy rats between ages of 8- 12 weeks

Exclusion Criteria:

  • weight loss of more than 15% of body weight

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Group placebo
Isotonic solution will be administered daily to 6 female rats.
Other: placebo comparator
solution containing 0.9 % sodium chlorine
Sham Comparator: Group sham
Base cream to be applied twice a day to 6 female rats.
Other: sham comparator
vaseline, beeswax,polyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water
Experimental: Group %1 mgso4
Cream containing 1% MgSO4 will be applied twice a day to 6 female rats.
Other: Experimental drug 1
A cream containing 10 % MgSO4.vaseline, beeswaxpolyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water
Experimental: Group %10 MgSO4
Cream containing 10% MgSO4 will be applied twice a day to 6 female rats.
Other: Experimental drug 2
A cream containing 10 % MgSO4.vaseline, beeswax,polyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water
Active Comparator: Group positive control
Cream containing centella asiatica will be applied twice a day to 6 female rats.
Drug: Centella asiatica
A cream containing Centella asiatica

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
7th day evaluation
Time Frame: 7th day
Histopathological evaluation of wound healing comparing with the rate of vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta) and hydroxyproline at immunohistochemical staining with biopsy on the 7th day.
7th day

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
15th day evaluation
Time Frame: 15th day
Histopathological evaluation of wound healing comparing with the rate of VEGF, TGF-beta and hydroxyproline at immunohistochemical staining with biopsy on the 15th day.
15th day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Basaksehir Cam & Sakura Şehir Hospital

Collaborators

Istanbul Kent University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 22, 2021

Primary Completion (Anticipated)

June 1, 2021

Study Completion (Anticipated)

July 1, 2021

Study Registration Dates

First Submitted

April 13, 2021

First Submitted That Met QC Criteria

May 10, 2021

First Posted (Actual)

May 14, 2021

Study Record Updates

Last Update Posted (Actual)

May 14, 2021

Last Update Submitted That Met QC Criteria

May 10, 2021

Last Verified

April 1, 2021

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SakuraDermatology1

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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