Understanding Visual Confusion Using Stereoscopic Displays

Monocular Visual Confusion for Field Expansion

In this research study we want to test how people understand a visual scene when the same image is presented to both the eyes, but portions of these images are altered in terms of contrast, depth or in some cases motion.

Study Overview

• Status: Completed
• Conditions: Diplopia; Binocular Vision Suppression; Binocular; Fusion, With Defective Stereopsis; Monocular Diplopia
• Intervention / Treatment: Behavioral: Binocular visual confusion (unilateral opaque); Behavioral: Unilateral monocular visual confusion (unilateral see-through); Behavioral: Bilateral monocular visual confusion (bilateral see-through)

• Study Type: Interventional
• Enrollment (Actual): 13
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Massachusetts
    • Boston, Massachusetts, United States, 02114
      • Schepens Eye Research Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Better than 20/40 visual acuity in the worse eye
• No restrictions of the peripheral visual field: (at least 60 degrees vertically and 40 degrees horizontally)
• At least 14 years of age (no upper age limit)
• Able to give voluntary, informed consent
• Able to understand English
• Binocular vision parameters within normal limits (Stereopsis ≤ 100 arc sec on any stereo test)

Exclusion criteria:

• Patients with any physical or mental disabilities, including cognitive dysfunction, balance problems, or other deficits that could impair their ability to respond to the stimuli presented in this study will be excluded
• Being unable to complete sessions lasting 2-3 hours

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: Visual confusion; Participants viewed peripheral targets in three different visual confusion conditions (three interventions): binocular visual confusion (unilateral opaque target), unilateral monocular visual confusion (unilateral see-through target), and bilateral monocular visual confusion (bilateral see-through target). Each intervention was presented twice in a randomized order, resulting in a total of six trials. During each trial, a peripheral target was presented in front of a forward-moving background for one minute. Participants were instructed to hold down the controller button while the target was visible and release it when a third or more of the target disappeared. After each trial, participants could take a brief break before the next trial in a different visual confusion condition was presented in a randomized order.

Behavioral: Binocular visual confusion (unilateral opaque); The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation. For the binocular visual confusion condition, the non-transparent (opaque) peripheral target will be displayed on only one eye (unilateral opaque display).; Behavioral: Unilateral monocular visual confusion (unilateral see-through); The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation. For the unilateral monocular visual confusion condition, the half-transparent peripheral target will be displayed on only one eye (unilateral see-through display).; Behavioral: Bilateral monocular visual confusion (bilateral see-through); The peripheral target was a horizontally drifting grating measuring 10° by 10°, with a spatial frequency of 1 cycle per degree and a temporal frequency of 3 Hz, and located at 10° above the fixation. For bilateral monocular visual confusion condition, the half-transparent peripheral target will be displayed on both eyes (bilateral see-through display).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Percentage of Total Viewing Time That Peripheral Target is Perceived	(Total time the peripheral target in the visual confusion condition was visible) / (total viewing time (=1 min))	Approximately 1-2 sessions to finish total 6 trials, up to 2 hours for each session, any time within the 4month study period

Collaborators and Investigators

• Sponsor: Massachusetts Eye and Ear Infirmary
• Collaborators: National Eye Institute (NEI)
• Investigators: Principal Investigator: JaeHyun Jung, Schepens Eye Research Institute

Study record dates

Study Major Dates

• Study Start (Actual): November 9, 2021
• Primary Completion (Actual): July 27, 2022
• Study Completion (Actual): July 27, 2022

Study Registration Dates

• First Submitted: June 28, 2021
• First Submitted That Met QC Criteria: July 7, 2021
• First Posted (Actual): July 12, 2021

Study Record Updates

• Last Update Posted (Actual): July 10, 2023
• Last Update Submitted That Met QC Criteria: June 16, 2023
• Last Verified: June 1, 2023

More Information

Terms related to this study

• Keywords: Binocular vision; Visual confusion; Rivalry; Head mounted display; Stereoscopic displays
• Additional Relevant MeSH Terms: Nervous System Diseases; Eye Diseases; Neurologic Manifestations; Neurobehavioral Manifestations; Sensation Disorders; Vision Disorders; Confusion; Diplopia
• Other Study ID Numbers: 2021P001757; R01EY031777 (U.S. NIH Grant/Contract)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No