Effects of Preoperative Coffee Consumption in Cesarean Sections Under Spinal Anesthesia

Effect of Preoperative Coffee Consumption on Intraoperative and Post Operative Outcomes in Cesarean Section With Spinal Anesthesia

The prospective study is planned in a university hospital. Spinal anesthesia is widely used for cesarean section currently for its safety, low cost, reliability, easiness to administer, immediate effect, and well-operating conditions. However spinal anesthesia has some complications as hypotension, bradycardia and Post Dural Puncture Headache (PDPH). A practical strategy for avoiding hypotension during initiation of spinal anesthesia for cesarean delivery includes intravenous crystalloid, in conjunction with administration of vasopressors. PDPH is one of the most frequent complications of spinal anesthesia. Conservative therapies such as bed rest, hydration, and caffeine are commonly used as management. For this study, coffee group of patients will be given unsweetened brewed coffee 150 ml until 2-4 hours before surgery. Patients who accept to drink brewed coffee ( coffee group) and water( control group) will be included in the study. The patient's heart rate, blood pressure, oxygen saturation will be monitored and recorded during operation. Intraoperative will be recorded to amount of vasopressor and intraveous crystalloid. Whether the patient develops PDPH in the postoperative period will be followed for 3 days. In addition abdominal auscultation for bowel sounds hourly and the time of first bowel movements will be recorded. According to the patient's statement, the time of first flatulence and defecation will be followed and recorded.

Study Overview

• Status: Completed
• Conditions: Post-Dural Puncture Headache; Hypotension After Spinal Anesthesia
• Intervention / Treatment: Other: coffee; Other: Water

• Study Type: Observational
• Enrollment (Actual): 2

Contacts and Locations

Study Locations

• Turkey
  • Kayseri, Turkey
    • Erciyes University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

parturient women aged 18-45

Description

Inclusion Criteria:

• patients who accept to participate in the study
• patient who limit the consumption of caffeinated beverages such as coffee and tea during pregnancy
• Patients with known caffeine or coffee allergy

Exclusion Criteria:

• patients who refuse to participate in the study
• Patients with known cardiovascular disease
• Patients with known cerebrovascular disease
• patients with known neurological, neurodegenerative or psychiatric disease
• patients with known liver failure
• patient followed up with eclampsia and preaclampsi
• higher number of needle passes in spinal anesthesia
• patients treated with an antiemetic

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
coffee (n= 70); Patients are planned to drink brewed coffee 2 hours before surgery.	Other: coffee; It will be given to patients brewed coffee to drink and evaluated to hypotension and post spinal puncture headache; Other Names: It will be given to patients brewed coffee to drink
control (n=70); Patients are planned to drink water 2 hours before surgery.	Other: Water; It will be given to patients water to drink and evaluated to hypotension and post spinal puncture headache; Other Names: It will be given to patients water to drink

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
hypotension	effects of orally coffee intake on spinal anesthesia induced hypotension	intraoperative time period

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Post-dural puncture headache	Effects of orally coffee intake on postdural puncture headache	post operative 3 days
intestinal motility, first flatus	Effects of orally coffee intake on postoperative intestinal motility	post operative 3 days

Collaborators and Investigators

• Sponsor: TC Erciyes University

Study record dates

Study Major Dates

• Study Start (Actual): March 15, 2022
• Primary Completion (Actual): June 1, 2022
• Study Completion (Actual): July 1, 2022

Study Registration Dates

• First Submitted: February 21, 2022
• First Submitted That Met QC Criteria: February 21, 2022
• First Posted (Actual): March 2, 2022

Study Record Updates

• Last Update Posted (Actual): May 16, 2024
• Last Update Submitted That Met QC Criteria: May 14, 2024
• Last Verified: May 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Headache Disorders; Headache Disorders, Secondary; Headache; Hypotension; Post-Dural Puncture Headache
• Other Study ID Numbers: 2021/825

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No