The Single Leg Squat Test to Evaluate Dynamic Knee Stability After ACLR

The Single Leg Squat and Hold Test With Kinematic Analysis to Evaluate Dynamic Knee Stability in Patients With ACL Injury

Patients with anterior cruciate ligament (ACL) injury often suffer knee instability, which can be visualized as a wobbling knee during weight bearing exercises, such as the single leg squat. We propose to use the single-leg-squat-and-hold (SLSH) task with kinematic analysis to objectively evaluate dynamic knee stability in ACL injured patients. The aim of this study is (1) to compare knee kinematic variations capturing knee wobbling during SLSH between ACL subjects and healthy controls; and (2) to detect the changes in knee kinematic variations during SLSH following ACL reconstruction.

Study Overview

• Status: Completed
• Conditions: ACL Injury
• Intervention / Treatment: Procedure: ACL reconstruction

Detailed Description

Injuries to the anterior cruciate ligament (ACL) are common in pivoting sports such as soccer, handball, basketball and rugby. The ultimate goal of ACL reconstruction for most athletes is return-to-play. Despite successful surgery and a demanding rehabilitation process, some athletes still failed to return to play, and for those who returned to play, some would suffer a second ACL injury. With surgical reconstruction of the ACL, static knee stability can be restored, but dynamic knee stability may not . Patients with ACL injury often experience symptoms such as knee instability, feelings of "giving way" during activities. Biomechanically, dynamic knee stability is considered as the ability to control the relative tibiofemoral displacements during loading.

Regular monitoring of the knee stability before and after ACL reconstruction is necessary for medical personnel to design the most suitable rehabilitation program. In contrast to jumping and hopping tasks, squatting tasks present a similar weight bearing profile during knee flexion, but without the potentially risky landing phase. As poor knee dynamic knee stability can be visualized as a wobbling knee (frequent knee movements). In order to quantitatively and objectively evaluate dynamic knee stability from observing the knee wobbling motion, we propose a single leg squat and hold task(SLSH) with kinematic analysis. Kinematic curve derived from the SLSH involves both the magnitudes and the frequency of the motion fluctuation. This study aims (1) to compare knee kinematic variations capturing knee wobbling during SLSH between ACL-deficient patients who are scheduled for ACLR and healthy controls; and(2)to detect the changes in knee kinematic variations during SLSH following ACLR. We hypothesize that the ACL-deficient patients demonstrate greater knee kinematic variation than the healthy subjects and the knee kinematic variation will reduce after ACLR.

• Study Type: Observational
• Enrollment (Actual): 43

Contacts and Locations

Study Locations

• Hong Kong
  • Hong Kong, Hong Kong
    • The Chinese University of Hong Kong

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Elite or recreational athletes with ACL injury who suffer knee instability and require surgical reconstruction

Description

Inclusion Criteria:

1. Aged 18-35;
2. Participate in level I or level II sports with a Tegner score of more than 6 before injury(level I: sports involving jumping, cutting and pivoting, e.g.football, basketball etc; Level II: sports involving lateral movements, less pivoting than Level I eg. racket sports)
3. Scheduled for ACLR because of unilateral ACL injury;
4. Failure to meet any single criteria for a potential coper;
5. Contralateral knee without history of injury.

Exclusion Criteria:

1. Concomitant fracture, meniscus injury or full-thickness chondral injuries;
2. preoperative radiographic signs of arthritis;
3. Revision ACL surgery;
4. With ankle pain, hip pain, low back pain or spine pathology;
5. Woman with pregnancy.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
ACL injured patients; All the ACL injured patients recruited underwent ACL reconstruction with the same group of surgeons lead by the same chief surgeon.	Procedure: ACL reconstruction; ACL reconstruction is a standard surgery for ACL injured patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes from baseline knee range of flexion-extension at 3 months after ACLR	knee range of flexion-extension will be measured during 10s holding phase of the single leg squat and hold test	three months post-operatively
Changes from baseline knee range of varus-valgus at 3 months after ACLR	knee range of virus-valgus will be measured during 10s holding phase of the single leg squat and hold test	three months post-operatively
Changes from baseline knee range of internal-external rotation at 3 months after ACLR	knee range of internal-external rotation will be measured during 10s holding phase of the single leg squat and hold test	one month pre-operatively and three months post-operatively
Changes from baseline frequency of knee flexion-extension at 3 months after ACLR	the frequency of the relative flexion-extension movements will be quantified by the number of peak appearances during 10s holding phase of the single leg squat and hold test	three months post-operatively
Changes from baseline frequency of knee varus-valgus at 3 months after ACLR	the frequency of the relative varus-valgus movements will be quantified by the number of peak appearances during 10s holding phase of the single leg squat and hold test	three months post-operatively
Changes from baseline frequency of knee internal-external rotation	he frequency of the relative internal-external movements will be quantified by the number of peak appearances during 10s holding phase of the single leg squat and hold test	three months post-operatively

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes from baseline International Knee Documentation Committee(IKDC) score at 3 months after ACLR	The IKDC is consisted of 10 questions about symptoms and activity ranging from 0 to 100 where 100 implies perfect knee function	three months post-operatively

Collaborators and Investigators

• Sponsor: Chinese University of Hong Kong
• Investigators: Principal Investigator: Xin He, PhD, Chinese University of Hong Kong

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2018
• Primary Completion (Actual): December 30, 2021
• Study Completion (Actual): December 30, 2021

Study Registration Dates

• First Submitted: March 10, 2022
• First Submitted That Met QC Criteria: March 21, 2022
• First Posted (Actual): March 24, 2022

Study Record Updates

• Last Update Posted (Actual): March 24, 2022
• Last Update Submitted That Met QC Criteria: March 21, 2022
• Last Verified: March 1, 2022

More Information

Terms related to this study

• Keywords: ACL reconstruction; Kinematics; single leg squat; knee instability
• Additional Relevant MeSH Terms: Wounds and Injuries; Leg Injuries; Knee Injuries; Anterior Cruciate Ligament Injuries
• Other Study ID Numbers: 2018.134

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No