Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis

March 30, 2022 updated by: Sarah Elkot, Future University in Egypt

Effect of Non Surgical Periodontal Treatment on Clinical Parameters and Gingival Crevicular Fluid Il-17 and Il-18 Levels in Aggressive Periodontitis Patients

clinical parameters and IL-17 and Il-18 GCF levels were measured in 25 aggressive periodontitis patients compared to 25 periodontally healthy individuals.

It was observed that that Clinical parameters and Il-17 and Il-18 levels are higher before treatment but decreased after treatment which suggests role of these interleukins in pathogenesis of aggressive periodontitis .

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Aggressive periodontitis is a type of rapidly progressing periodontal diseases .The three classic primary characteristics of this disease are ; occurring in young healthy patients with rapid attachment loss and familial aggregation .Bacteria-host interactions, insufficiencies in host defenses and possibly a genetic predisposition represent the etiologic factors . Beside the young age of onset, important factors as involvement of host factors and non-plaque-related etiologic factors have also been proposed .

Aim of the study:

Objectives were to compare and correlate the clinical parameters and biochemical parameters (Il-17 and Il-18 levels in GCF) of aggressive periodontitis patients (At baseline and after three months of nonsurgical treatment) versus periodontally healthy subjects at baseline.

Subjects and methods:

Populations included in the study:

A total of fifty individuals were enrolled and categorized as; group A that included twenty five aggressive periodontitis patients and group B which included twenty five periodontally healthy controls.

Clinical parameters:

Plaque index (PI) ,gingival index (GI), Probing pocket depth (PPD) and clinical attachment level (CAL) were measured at baseline for both groups and after three months of non surgical periodontal treatment completion for group A.

GCF sampling:

In group A ,the site with deepest probing depth was selected for GCF sampling while for group B , any site was sampled using PerioPaper strips .

Phase I periodontal treatment After baseline GCF sample collection and clinical measurement recordings, group A patients received phase I periodontal treatment.

Analysis of Il-17 and Il-18 levels in GCF:

GCF samples were examined by enzyme-linked immunosorbent assay (ELISA).Procedures were performed according to the directions in the kits.

Study Type

Observational

Enrollment (Actual)

50

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Cairo, Egypt, 11835
        • Faculty of oral and dental medicine,FUE, Cairo,Egypt

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 30 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Both genders Age between 18 and 30 years old

Description

Inclusion Criteria:

-Medically free subjects.

Exclusion Criteria:

  • Subjects with periodontal surgeries in the last 6 months.
  • Subjects with prior use of antibiotics in the last 6 months.
  • Smokers.
  • Pregnant females.
  • Lactating females.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Aggressive periodontitis
25 young medically free patients with deep periodontal pockets >5mm
Procedure: non surgical periodontal therapy
Scaling and root planing
Periodontally healthy individuals
25 young medically free individuals with no periodontal inflammation signs

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Periopaper strips Il-17 and Il-18 GCF measurements
Time Frame: Change from Baseline Il-17 and Il-18 at 3 months
measurement of Il-17 and Il-18 in GCF from aggressive periodontitis patients using periopaper strips
Change from Baseline Il-17 and Il-18 at 3 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Future University in Egypt

Investigators

  • Principal Investigator: Sarah M Elkot, Lecturer, Lecturer of Oral Medicine and Periodontology

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 27, 2021

Primary Completion (Actual)

December 15, 2021

Study Completion (Actual)

December 30, 2021

Study Registration Dates

First Submitted

March 2, 2022

First Submitted That Met QC Criteria

March 16, 2022

First Posted (Actual)

March 25, 2022

Study Record Updates

Last Update Posted (Actual)

April 7, 2022

Last Update Submitted That Met QC Criteria

March 30, 2022

Last Verified

March 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • FUE11

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Subscribe