Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia

Effects of Nonsurgical Periodontal Therapy on Biomarkers in Serum and Gingival Crevicular Fluid in Severe Periodontitis (Stage III/IV) and Hyperlipidemia:A Cohort Study

Sponsors

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Brief Summary

This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.

Detailed Description

This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.MCP-1, IL-8, oxLDL, TNF-α will be tested for concentration using ELISA.

Overall Status Recruiting
Start Date 2022-09-20
Completion Date 2023-11-01
Primary Completion Date 2023-11-01
Study Type Observational
Primary Outcome
Measure Time Frame
monocyte chemotactic protein-1,MCP-1 Before surgery
monocyte chemotactic protein-1,MCP-1 1 month after surgery
monocyte chemotactic protein-1,MCP-1 3 months after surgery
oxidized low-density lipoprotein cholesterol, oxLDL Before surgery
oxidized low-density lipoprotein cholesterol, oxLDL 1 month after surgery
oxidized low-density lipoprotein cholesterol, oxLDL 3 months after surgery
Secondary Outcome
Measure Time Frame
interleukin-8,IL-8 Before surgery
interleukin-8,IL-8 1 month after surgery
interleukin-8,IL-8 3 months after surgery
triglycerides,TG Before surgery
triglycerides,TG 1 month after surgery
triglycerides,TG 3 months after surgery
low-density lipoprotein cholesterol,LDL-C Before surgery
low-density lipoprotein cholesterol,LDL-C 1 month after surgery
low-density lipoprotein cholesterol,LDL-C 3 months after surgery
high-density lipoprotein cholesterol,HDL-C Before surgery
high-density lipoprotein cholesterol,HDL-C 1 month after surgery
high-density lipoprotein cholesterol,HDL-C 3 months after surgery
probing depth,PD Before surgery
probing depth,PD 1 month after surgery
probing depth,PD 3 months after surgery
clinical attachment level,CAL Before surgery
clinical attachment level,CAL 1 month after surgery
clinical attachment level,CAL 3 months after surgery
percentage of bleeding on probing,BOP% Before surgery
percentage of bleeding on probing,BOP% 1 month after surgery
percentage of bleeding on probing,BOP% 3 months after surgery
Enrollment 64
Condition
Intervention

Intervention Type: Procedure

Intervention Name: non-surgical periodontal therapy

Description: supragingival scaling,subgingival scaling

Eligibility

Sampling Method:

Non-Probability Sample

Criteria:

Inclusion Criteria: - Subjects had to meet at least one of the following criteria for the diagnosis of hyperlipidemia: triglyceride (TRG) levels >2.26 mmol/L; high density lipoprotein cholesterol (HDL-C) levels <1.04 mmol/L; or low density lipoprotein cholesterol (LDL-C) levels >4.14 mmol/L - Patients with severe periodontitis (stage III/IV) with probing depth (PD) ≥ 6 mm at at least six sites, at least two multi-rooted or two single-rooted teeth in at least one quadrant, and extended bone loss on imaging to the middle or top third of the root. Periodontitis results in the loss of less than or equal to four teeth. Exclusion Criteria: - systemic illnesses - pregnancy or lactation - systemic antibiotics taken within the previous 6 months - use of cholesterol reduction medication during the past 6 months - subgingival scaling and root planing or surgical periodontal therapy in the last year - chewing smokeless tobacco, smoking pipes or cigars 1 or more times per week, or smoking more than 20 cigarettes per week (1 pack per week) in the past 6 months

Gender:

All

Minimum Age:

18 Years

Maximum Age:

80 Years

Overall Contact

Last Name: Yanmin Wu

Phone: +86 137 5711 9560

Email: [email protected]

Location
Facility: Status: Contact: 2nd Affiliated Hospital, School of Medicine, Zhejiang University Yanmin Wu +86 0571 87783607 [email protected]
Location Countries

China

Verification Date

2022-09-01

Responsible Party

Type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: HP

Description: Chronic periodontitis (stage III/IV) patients with hyperlipidemia

Label: CP

Description: Chronic periodontitis(stage III/IV) patients without hyperlipidemia

Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

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