- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05442255
Toxicological Analysis in Chemical Submission (TANCS)
January 12, 2023 updated by: Assistance Publique - Hôpitaux de Paris
The purpose of this study is to carry out a systematic toxicological analysis of all the patients, examined at the UMJ of the Hôtel-Dieu following a complaint for suspected chemical submission.
By comparing the toxicological data with the clinical examination data (e.g.
treatment intake), the investigators could determine the number of confirmed chemical submissions and the substances involved.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The number of chemical submissions has been constantly increasing in France for several years.
The Parisian Center of Evaluation and Information on Pharmacodependence and Addictovigilance collects notifications of chemical submissions demonstrated by toxicological analyses.
For the year 2017, 544 notifications were received by this structure.
For cases of probable chemical submission, drugs were involved in more than 75% of cases, mostly benzodiazepines.
In Europe, there are few cohort studies on the toxicological analysis of suspected chemical submissions.
A systematic review of the literature carried out in 2017 by Anderson et al. reports that most studies deal with isolated cases of chemical submission involving a specific and unusual psychoactive substance or are in fact toxicological studies aiming to develop a new analytical technique concerning a substance.
Few relevant European cohort studies on this subject have been carried out and most of them are more than ten years old.
The Medico-Judicial Unit of the Hôtel-Dieu (UMJ) receives victims of chemical subjection following the filing of a complaint, upon judicial requisition.
Complaints can concern a suspicion of chemical submission alone, or a suspicion of chemical submission associated with a suspicion of sexual assault or a robbery.
In these cases, the judicial requisition systematically includes a request for toxicological samples (blood and urine).
Depending on the data of the investigation, the judicial authority will decide to have the toxicological analyses of these samples performed.
In 2018, at the UMJ of Hôtel-Dieu, 231 conservative samples were taken in cases of suspected chemical submissions.
As of the writing of this work (November 2019), only 72 samples have been sealed by the judicial authority, i.e. 31.2% of the cases.
Moreover, the results of these analyses are not systematically communicated to the UMJ of the Hôtel-Dieu de Paris nor to the patients.
Each year, the Medico-Judicial Unit (UMJ) of the Hôtel-Dieu Hospital in Paris receives between 12,000 and 15,000 alleged victims of criminal offences following their filing of a complaint for medical examination on judicial requisition.
Among this population, our study will specifically focus on adults who have filed a complaint for suspected chemical submission.
The investigators would like to carry out a systematic toxicological analysis of all the patients who have been examined at the UMJ of the Hôtel-Dieu following a complaint for suspected chemical submission.
By comparing the toxicological data with the clinical examination data (e.g.
treatment intake), the investigators could determine the number of confirmed chemical submissions and the substances involved.
This work has several interests.
It would allow us to refine our knowledge of the substances used in chemical submissions, and to determine a possible specificity of the substances used in Paris by comparing our data with those existing in the medical literature, at the European and global levels.
The data concerning the proven chemical submissions would be transmitted to the CEIP-A, thus allowing an active participation in the toxicovigilance network.
A high number of proven chemical submissions would also alert the judicial authorities to the need to carry out toxicological analyses in a more systematic way.
Finally, the investigators will systematically propose to the patients included in the study that they receive their results during the follow-up consultation, which is usually carried out within 3 months of the initial consultation.
This last point will allow us to improve the management of these patients, by providing them with the answers necessary for the psychological reconstruction process.
Study Type
Observational
Enrollment (Actual)
100
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
IDF
-
Paris, IDF, France, 75004
- Hôtel-Dieu Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Alleged victims of criminal offences following their filing of a complaint for medical examination on judicial requisition, seen in the Medico-Judicial Unit (UMJ) of the Hôtel-Dieu Hospital in Paris, France.
Description
Inclusion Criteria:
- Be of legal age (≥ 18) on the day of the exam,
- Have filed a complaint for a suspected chemical chemical,
- Be in possession of a judicial requisition requesting the to take biological samples (blood and urine)
- Claim to be the victim of a suspected chemical chemical submission that took place less than 5 days before the consultation,
- Be affiliated or entitled to a social security system,
- Having been informed of the research and not having opposed to his participation.
Exclusion Criteria:
- Patient under court protection
- Minor patient (< 18 ans),
- Patient under guardianship,
- Patient who does not speak French,
- Patient with psychotic / cognitive symptoms that may impair their judgment,
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Chemical Submission
Patients with a suspected chemical submission
|
Automated enzymatic assays Automated Immunoassay Urine Screening High Resolution Toxicological Screening
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Presence of one or more psychoactive substances
Time Frame: Day of inclusion
|
Identify the presence of one or more psychoactive substances in the tests performed (blood).
|
Day of inclusion
|
Presence of one or more psychoactive substances
Time Frame: Day of inclusion
|
Identify the presence of one or more psychoactive substances in the tests performed (urines).
|
Day of inclusion
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Questionnaire
Time Frame: Day of inclusion
|
Questionnaire to identify if voluntary intake of one or more psychoactive substance(s) within 24 hours leading to the suspicion of chemical submission.
|
Day of inclusion
|
Quantification of ethanol
Time Frame: Day of inclusion
|
Quantification of ethanol and/or ethylglucuronide (its metabolite) in samples
|
Day of inclusion
|
Quantification of ethylglucuronide
Time Frame: Day of inclusion
|
Quantification of ethanol and/or ethylglucuronide (its metabolite) in samples
|
Day of inclusion
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: DUFAYET Laurène, MD, Assistance Publique - Hôpitaux de Paris
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
March 1, 2021
Primary Completion (Actual)
April 15, 2022
Study Completion (Actual)
July 27, 2022
Study Registration Dates
First Submitted
June 28, 2022
First Submitted That Met QC Criteria
June 28, 2022
First Posted (Actual)
July 1, 2022
Study Record Updates
Last Update Posted (Estimate)
January 13, 2023
Last Update Submitted That Met QC Criteria
January 12, 2023
Last Verified
January 1, 2023
More Information
Terms related to this study
Other Study ID Numbers
- APHP200054
- 2019-A03134-53 (Other Identifier: ANSM)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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