- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05478759
Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD
Study Overview
Status
Conditions
Detailed Description
Background. Deficits in emotion recognition are common in traumatic brain injury (TBI) and in post-traumatic stress disorder (PTSD) but these deficits have not been well studied in Veterans with both mild TBI (mTBI) and PTSD. Poor emotion recognition has been associated with poor quality of interpersonal relationships, loss of employment, behavioral problems, reduced social reintegration, social isolation and even suicide. Currently there are no interventions for emotion recognition deficits in Veterans with mTBI and PTSD, and interventions conducted in civilians with severe TBI have lacked training of both facial and vocal emotion recognition. In a preliminary study of an innovative combination of facial and vocal modalities, a multimodal affect recognition training (MMART) showed promise with significant improvement on the Florida Affect Battery (FAB) but lacked attention training that is an essential component in recognizing rapidly changing emotions in our everyday lives. Attention training using Brain HQ targets the required attention factors underlying emotion recognition. Given the need to improve relationships and productivity in Veterans with mTBI and PTSD, a randomized controlled trial is needed to determine the effectiveness of an innovative MMART combined with attention training to improve emotion recognition and everyday function.
Objective & Hypotheses. The objective of this randomized controlled trial is to determine the treatment effect of a MultiModal Affect Recognition Training (MMART) combined with attention training in Veterans with TBI/PTSD.
Hypothesis 1. MMART combined with attention training will significantly improve performance on tests of emotion recognition.
Hypothesis 2: Treatment gains will translate to functional activities. Primary measures. Florida Affect Battery (FAB) and the Community Reintegration in Service members (CRIS).
Secondary measures. Emotion Recognition Task (ERT), attention index of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Continuous Performance Task and the TBI Quality of Life (TBI-QOL) Ability to Participate in Social Roles and Activities.
Methods. 20 Veterans with mTBI and PTSD will be randomized to either the combined training or an inactive control group. Both groups will attend 16, one-hour in-person sessions over 8 weeks. Outcomes will be assessed at pre-, post-, 3 month-post-treatment. A linear regression will be used to determine significant improvement of the treatment group over the control group, with t-tests to demonstrate within group improvement. Effect size calculations will be used to determine the power needed for a future Merit proposal.
Study Type
Enrollment (Estimated)
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Julia K Waid-Ebbs, PhD
- Phone Number: (352) 376-1611
- Email: Julia.Waid-Ebbs@va.gov
Study Contact Backup
- Name: Margaret H McCallum
- Phone Number: 5223 (352) 376-1611
- Email: Margaret.McCallum@va.gov
Study Locations
-
-
Florida
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Gainesville, Florida, United States, 32608-1135
- Recruiting
- North Florida/South Georgia Veterans Health System, Gainesville, FL
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Contact:
- Yi Zhang, PhD
- Phone Number: 5046 (352) 548-6000
- Email: yizhang@ufl.edu
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Principal Investigator:
- Julia K. Waid-Ebbs, PhD
-
Contact:
- Margaret H McCallum
- Phone Number: 5223 352-376-1611
- Email: Margaret.McCallum@va.gov
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Veterans with a diagnosis of mTBI and PTSD based on VA/Department of Defense guidelines.
- Emotion recognition deficit
- Attention deficit
- Corrected vision within normal limits
- Hearing within normal limits
- Fluent in English
Exclusion Criteria:
- premorbid history of schizophrenia
- bipolar disorder
- chronic medical or neurological diseases
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: MMART and attention training
Training to recognize affect and prosodic expressions of emotions combined with attention training.
|
8 session, trains participants to recognize expression of emotion from a variety of stimuli, including dynamic stimuli (e.g., video instead of still pictures) and it employs both facial and vocal examples of emotion expression.
Other Names:
computerized attention drill training
Other Names:
|
Placebo Comparator: Brain Health Workshop and National Geographic Movies
an inactive arm that matches sessions of intervention.
BHW is education about the brain and cognition.
National Geographic movies are viewed with the clinician and the participant answers questions about the movies.
|
an education presentation on brain function and cognitive principles of learning with homework and quizzes on information covered.
Other Names:
participant will watch movies and answer questions after
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Florida Affect Battery (FAB), assessing change
Time Frame: week 1, week 11, week 22
|
a standardized assessment of emotional affect and prosody recognition.
normative scores range from 0-100 for each of the 12 subscales.
Higher scores indicate better emotion recognition.
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week 1, week 11, week 22
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Community Reintegration of Service Members, assessing change
Time Frame: week 1, week 11, week 22
|
Satisfaction questionnaire of community participation.
Scores range from .43 to 2.15.
43 items with five rating options of 1-5.
Higher scores indicate better community participation.
|
week 1, week 11, week 22
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Emotion Recognition Task, assessing change
Time Frame: week 1, week 11, week 22
|
computerized assessment of emotional affect recognition.
Correct responses range from 0-48 (higher scores indicate better emotion recognition) and correct response time ranges from 0 to infinity (lower scores indicate quicker response time).
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week 1, week 11, week 22
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Continuous Performance Task, assessing change
Time Frame: week 1, week 11, week 22
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computerized measures of sustained attention.
100 trials with accuracy ranging from 0-100 (higher scores indicate better attention) and response time from 0-60 (lower scores indicate quicker response time).
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week 1, week 11, week 22
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Attention Index of the Repeatable Battery for the Assessment of Neuropsychological Status, assessing change
Time Frame: week 1, week 11, week 22
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digit span and symbol digit to assess attention.
Scaled scores range from 1-19, with higher scores indicating better attention.
|
week 1, week 11, week 22
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Traumatic Brain injury quality of life
Time Frame: week 1, week 11, week 22
|
quality of life questionnaire about community participation.
59 items with scores ranging from 59-295, with higher scores indicating better community participation.
|
week 1, week 11, week 22
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Collaborators and Investigators
Investigators
- Principal Investigator: Julia K. Waid-Ebbs, PhD, North Florida/South Georgia Veterans Health System, Gainesville, FL
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- D4411-P
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- ANALYTIC_CODE
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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