Neuromodulation and Fatigue

April 3, 2026 updated by: University of Oklahoma

Neuromodulation and Its Effects on Muscle Activity and Fatigue

In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation. Healthy individuals will participate in one familiarization followed by up to 6 experimental sessions. Fatigability and motor function will be assessed in each test session.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

This project will investigate the potential impact of an electrical current of low intensity, and applied non-invasively, on the signals that drive muscle contractions. Individuals will receive distinct types of stimulation that vary depending on the direction on the current (anodal vs cathodal) and placement of the electrodes. These conditions will be compared to a sham stimulation. The test session will be randomized in a double blind fashion, which indicates that neither participants or investigators will know the type of stimulation. Motor function and the muscle electrical activity will be quantified during each test session.

Study Type

Interventional

Enrollment (Estimated)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Hugo Pereira, PhD
  • Phone Number: 405-325-2773
  • Email: hugomax@ou.edu

Study Locations

  • United States
    • Oklahoma
      • Norman, Oklahoma, United States, 73071
        • Recruiting
        • University of Oklahoma
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 50 years (Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

Healthy individuals between 18 and 50 years old

Exclusion Criteria:

Metal implants or joint replacement. Presence of neuromuscular disease. Skin hypersensitivity.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Single Group Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Men
Individuals will participate in 1 familiarization and up to 6 test sessions
Behavioral: electrical stimulation
different types of low-intensity (comfortable) electrical stimulation will be used and applied in distinct locations
Experimental: Women
Individuals will participate in 1 familiarization and up to 6 test sessions
Behavioral: electrical stimulation
different types of low-intensity (comfortable) electrical stimulation will be used and applied in distinct locations

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Force
Time Frame: Each session will take approximately 2 hours (total of 4 test sessions)
Change in force will be evaluated with a device during each test session
Each session will take approximately 2 hours (total of 4 test sessions)
Perception of effort
Time Frame: Each session will take approximately 2 hours (total of 4 test sessions)
Change in perceived effort will be evaluated with visual analogue scales
Each session will take approximately 2 hours (total of 4 test sessions)
Muscle activation
Time Frame: Each session will take approximately 2 hours (total of 4 test sessions)
Electromyography will be used to quantify muscle activation
Each session will take approximately 2 hours (total of 4 test sessions)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Oklahoma

Investigators

  • Principal Investigator: Hugo Pereira, PhD, University of Oklahoma

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 3, 2023

Primary Completion (Estimated)

September 1, 2027

Study Completion (Estimated)

December 1, 2027

Study Registration Dates

First Submitted

August 2, 2022

First Submitted That Met QC Criteria

August 2, 2022

First Posted (Actual)

August 4, 2022

Study Record Updates

Last Update Posted (Actual)

April 9, 2026

Last Update Submitted That Met QC Criteria

April 3, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 14921P

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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