Influence of Ambient Temperature on Resting Energy Expenditure of Healthy Adults

Influence of Ambient Temperature on Resting Energy Expenditure of Metabolically Healthy Men and Women

The aim of this study is to investigate the influence of four different ambient temperatures (18, 22, 28, 38°C) on the resting energy expenditure of healthy adults by respiratory gas analysis. It is assumed that the resting energy expenditure is higher at 18°C and 38°C than at the temperatures in between.

Study Overview

• Status: Completed
• Conditions: Resting Energy Expenditure
• Intervention / Treatment: Other: Respiratory analysis at cold temperature; Other: Respiratory analysis at room temperature; Other: Respiratory analysis at thermoneutral temperature; Other: Respiratory analysis at hot temperature

Detailed Description

In a crossover-design, 32 healthy men and women participate in four interventions. Each intervention includes a measurement of the resting energy expenditure by respiratory gas analysis at a different ambient temperature (18,22, 28 and 38°C). During this time body core- and surface temperature are assessed, as well as body composition via bioelectrical impedance analysis. For each participant the four individual study days take place in a randomized order on consecutive weekdays within a week.

• Study Type: Interventional
• Enrollment (Actual): 32
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Germany
  • Bonn, Germany, 53115
    • University of Bonn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria

• BMI: 18,5 - 24,9 kg/m2
• metabolically healthy

Exclusion Criteria

• smoking
• low or high blood pressure
• dyslipidemia
• insulin resistance or diabetes mellitus type 1 or type 2
• gastrointestinal diseases (e.g. food intolerances or allergies)
• liver, kidney and/or thyroid diseases
• hepatitis B or C, HIV Infection
• chronic inflammatory diseases
• disordered eating
• psychological diseases
• alcohol and/or drug abuse
• use of medication
• pregnancy or lactating
• participation in another intervention study
• women: irregular menstrual cycle
• more than 6 h of sports per week

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Cold temperature; 18°C	Other: Respiratory analysis at cold temperature; Respiratory analysis at an ambient temperature of 18°C
Experimental: Room temperature; 22°C	Other: Respiratory analysis at room temperature; Respiratory analysis at an ambient temperature of 22°C
Experimental: Thermoneutral temperature; 28°C	Other: Respiratory analysis at thermoneutral temperature; Respiratory analysis at an ambient temperature of 28°C
Experimental: Hot temperature; 38°C	Other: Respiratory analysis at hot temperature; Respiratory analysis at an ambient temperature of 38°C

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Resting Energy Expenditure	Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min	20 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Body core temperature	Body core temperature: assessed every ten seconds during respiratory analysis (°C)	20 minutes
Body surface temperature	Body surface temperature: assessed every ten seconds during respiratory analysis (°C)	20 minutes
Body composition	assessed daily via bioelectrical impedance analysis after respiratory analysis (FFM (kg), FM (kg))	5 minutes (after respiratory analysis)
Blood pressure	assessed daily before respiratory analysis (mmHg)	10 minutes (at beginning of study day)

Collaborators and Investigators

• Sponsor: University of Bonn
• Collaborators: DLR German Aerospace Center
• Investigators: Principal Investigator: Sarah Egert, Prof. PhD, University of Bonn

Study record dates

Study Major Dates

• Study Start (Actual): November 21, 2022
• Primary Completion (Actual): April 6, 2023
• Study Completion (Actual): April 6, 2023

Study Registration Dates

• First Submitted: August 15, 2022
• First Submitted That Met QC Criteria: August 15, 2022
• First Posted (Actual): August 17, 2022

Study Record Updates

• Last Update Posted (Actual): April 12, 2023
• Last Update Submitted That Met QC Criteria: April 11, 2023
• Last Verified: April 1, 2023

More Information

Terms related to this study

• Keywords: Resting metabolic rate; Resting energy expenditure; Ambient temperature; Environmental temperature
• Other Study ID Numbers: TempRMR

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No