- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05588154
Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies
Background:
Myelodysplastic syndromes (MDS) are disorders of blood stem cells that can develop into blood cancers. Treatment options are limited. To find better treatments, researchers need to better understand how MDS develops. To do that, they must be able to compare biospecimens from people with the disease to those of healthy people.
Objective:
This study will create a database of biospecimens collected from healthy volunteers.
Eligibility:
Healthy people aged 18 and older.
Design:
Participants will be screened. They will have a physical exam with blood and urine tests.
Up to 5 types of samples will be collected on 1 or more days within 1 month of screening:
Blood: Blood will be drawn by inserting a needle into a vein.
Saliva: Participants will scrape the insides of their cheeks with a brush.
Stool: Participants will be given a container to collect stool at home. They will use a prepaid envelope to mail in the sample.
Bone marrow: A sample of the soft tissue inside the bones will be drawn out. The area to be biopsied, usually the lower back, will be numbed. A needle will be inserted through a small cut to remove the sample. Participants' pain will be monitored; additional numbing medicine may be used.
Skin: A piece of skin about 1/6 of an inch across will be cut away. Stitches may be used to close the wound. Participants will return to the clinic to have the stitches removed.
Participants do not have to provide all of the samples listed. They will give each sample only once.
Study Overview
Status
Conditions
Detailed Description
Background:
- Myelodysplastic syndromes (MDS) are heterogeneous stem cell disorders characterized by ineffective hematopoiesis resulting in cellular dysplasia, peripheral cytopenias, and increased risk for transformation to acute myeloid leukemia (AML).
- There are limited treatment options, all of which have unimpressive response rates and limited response durations, with the only potential cure being hematopoietic stem cell transplant (HSCT). Unfortunately, as a disease of the elderly (average age of diagnosis >65 years), most participants are not eligible for HSCT due to advanced age and other comorbidities.
- It is critical we further elucidate the processes that lead to disease manifestation to develop novel therapeutic strategies and alter the natural history of the disease.
- In order to understand the biology of the disease, it is critical to have control biospecimens from healthy individuals to delineate the mechanisms driving disease pathogenesis.
Objective:
-To create a database of analyzed biospecimens collected from healthy volunteers.
Eligibility:
- Age >= 18 years old
- Healthy volunteers as confirmed by clinical evaluation
Design:
This is a trial to analyze samples from healthy volunteers collected at NIH Clinical Center.
--Participants = will be asked to provide blood, and/or bone marrow, and other samples (skin biopsy samples, saliva, stool samples).
- The total protocol accrual goal is 1,000 participants. Enrollment is expected to take place over approximately 20-50 years.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Kathy McGraw, Ph.D.
- Phone Number: (240) 760-7134
- Email: kathy.mcgraw@nih.gov
Study Contact Backup
- Name: Rebecca Alexander
- Phone Number: (240) 781-4037
- Email: rebecca.alexander@nih.gov
Study Locations
-
-
Maryland
-
Bethesda, Maryland, United States, 20892
- Recruiting
- National Institutes of Health Clinical Center
-
Contact:
- For more information at the NIH Clinical Center contact National Cancer Institute Referral Office
- Phone Number: 888-624-1937
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
- INCLUSION CRITERIA:
- Age >= 18 years old
- Healthy volunteers; the following confirmed by the Principal Investigator or designees based on recent (within 3 months before study intervention(s))
- medical history
- physical exam
- complete blood count (CBC) within the normal reference range per the reporting clinical laboratory, established published literature and reports, or as deemed acceptable by the medical team based on the age and condition of the volunteer consistent with established clinical standards.
- The ability of the participant to understand and the willingness to sign a written consent document.
EXCLUSION CRITERIA:
- Active illnesses, immunodeficiency, history of opportunistic infection, autoimmune disease, history of or active malignancy, prior organ, bone marrow, or peripheral blood stem cell transplant or antibiotic treatment within 3 months before study intervention(s).
Note: participants with non-melanoma skin cancer or carcinoma in situ of the cervix or breast are eligible.
- Current immunosuppressive medication.
- Any one of the following symptoms as declared by the participant at least one day per week within 3 months before study intervention(s) (Rome IV criteria [36])
- Diarrhea characterized as frequent (>2) loose stools
- Constipation defined as < 3 spontaneous bowel movements per week
- Bloating and/or distention
- Abdominal pain.
- Participants with a history of the human immunodeficiency virus (HIV), hepatitis C (HCV), or hepatitis B (HBV) as confirmed by a seropositive blood test.
- Pregnancy confirmed with beta-Human Chorionic Gonadotropin (Beta-HCG) serum or urine pregnancy test performed in women of childbearing potential at screening.
- Breastfeeding participants.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
---|
Cohort 1
Healthy volunteers who will donate blood, and/or bone marrow and may donate other samples
|
Cohort 2
Healthy volunteers who will donate stool samples only
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
create a database of analyzed biospecimens
Time Frame: ongoing
|
Collection of biospecimens from healthy volunteers.
|
ongoing
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Kathy McGraw, Ph.D., National Cancer Institute (NCI)
Publications and helpful links
Helpful Links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 10000975
- 000975-C
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ICF
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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