TRAcking Thoracic Cancer Evolution Through Therapy (Rx) EVO

TRACERx EVO is a programme of work using a prospective observational cohort study of participants with early- and late-stage non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) and pleural mesothelioma.

Study Overview

• Status: Recruiting
• Conditions: Small Cell Lung Cancer; Lung Cancer, Non-small Cell; Pleural Mesothelioma

Detailed Description

TRACERx EVO is a programme of work linked to an observational cohort study that consists of early and late-stage lung cancer and pleural mesothelioma. Participants will receive anti-cancer therapies (systemic therapies, radiotherapy and surgery, as per local and national guidelines). This study involves collecting a large amount of data, covering demographic and clinical characteristics, data throughout their follow up from the time of baseline/surgery, genomics and all other laboratory results using their blood, tissue, urine, saliva and stool samples. Data would also be retrieved from participant medical records. As such, there will be a wide range of analyses

• Study Type: Observational
• Enrollment (Estimated): 600

Contacts and Locations

• Study Contact: Name: Zainab Kalokoh; Phone Number: 02076799872 02031085363; Email: ctc.tracerxevo@ucl.ac.uk
• Study Contact Backup: Name: Aoife Walker; Phone Number: 02031085363

Study Locations

• United Kingdom
  • London, United Kingdom, NW1 2PG
    • Recruiting
    • University College London Hospitals Nhs Foundation Trust

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

I-IIIC or de novo metastatic (stage IV) Non-small cell lung cancer, stage I-IV Small cell lung cancer, pleural mesothelioma.

Description

Inclusion Criteria:

• Cohort A, B and C :

  • Written Informed consent
  • Agreement to be followed up (including on-study assessments and sample collection) every 3 months in the first 2 years and then 6 monthly.
  • Agreement to be followed up at a TRACERx EVO site

Cohort A:

• Participants ≥18 years of age, with early stage I-IIIB NSCLC disease who are eligible for primary surgery
• Histopathologically confirmed NSCLC, or a strong suspicion of cancer on lung imaging necessitating surgery (e.g., diagnosis determined from frozen section in theatre)
• Primary surgery in keeping with NICE guidelines in (lobectomy, either open or thoracoscopic), lung parenchymal-sparing operations (segmentectomy or wedge resection) if a complete resection can be achieved, extensive surgery (bronchoangioplastic surgery, bilobectomy, pneumonectomy) if necessary to obtain clear margins, hilar and mediastinal lymph node sampling or en bloc resection)
• For participants proceeding with upfront primary surgery (i.e. no neoadjuvant therapy), a minimum tumour diameter at least 15mm to allow for sampling of at least two tumour regions
• Participants undergoing neoadjuvant treatment must have at least 1 region of fresh frozen or FFPE surgical or diagnostic biopsy tissue.
• Considered sufficiently fit for upfront standard of care primary surgery or neoadjuvant therapy if indicated
• Performance status 0 to 2

Cohort B:

• Participants ≥18 years of age, with late-stage unresectable stage IIIB and above NSCLC disease (TNM 8th edition) or presenting with stage IV de novo metastatic disease.
• Sufficient tissue (at least 1 region/biopsy), either FFPE or fresh frozen
• Deemed to be fit for anti-cancer treatment
• Performance status 0 to 2 Participants who were initially consented into Cohort A with a post-surgical staging of stage IIIB/C or IV could be included in Cohort B.

Cohort C:

• Participants ≥18 years of age, with any stage SCLC or pleural mesothelioma.
• Sufficient tissue (at least 1 region/biopsy), either FFPE or fresh frozen
• Deemed to be fit for anti-cancer treatment
• Performance status 0 to 2

Exclusion Criteria:

• Cohort A, B and C:

  • Other active malignancy
  • Any other* malignancy diagnosed or relapsed at any time, which is currently being treated (including by hormonal therapy).

  • Any other* current malignancy or malignancy diagnosed or relapsed within the past 3 years**.

    • *Exceptions are: non-melanomatous skin cancer, stage 0 melanoma in situ, and in situ cervical cancer
    • **An exception will be made for malignancies diagnosed or relapsed more than 2, but less than 3, years ago only if a pre-operative biopsy of the lung lesion has confirmed a diagnosis of NSCLC.
  • Psychological condition that would preclude informed consent
  • Diagnosis other than NSCLC, SCLC or pleural mesothelioma confirmed following surgery or biopsy
  • Confirmed diagnosis of known high-risk infections (e.g., Human Immunodeficiency Virus) (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) or syphilis infection, tuberculosis and Creutzfeldt-Jacob disease) unless participant case is of a particular scientific interest and agreed in advance with research staff, local mortuary staff and pathologist.
  • Contra-indicated co-morbid conditions

Cohort A:

• Positive margins, incomplete resection or insufficient nodal sampling
• Insufficient tissue, i.e., for participants having upfront surgery and not having neoadjuvant therapy, a minimum of two tumour regions unlikely to be obtained for the study based on pre-operative imaging. For participants having neoadjuvant therapy i.e., at least one tissue biopsy to be obtained (Fresh Frozen or FFPE).
• Participant found to have pre-invasive lesions rather than invasive cancer following surgery, such as adenocarcinoma in situ or minimally invasive lesions will be withdrawn. However, the surgical tissue and baseline blood already collected will be sent to the central laboratory. These participants will not be followed-up in the study or required to provide any further blood samples. If these participants subsequently develop invasive cancer, the date of diagnosis and the tumour histology will be reported on the electronic data capture system.

Cohort B/C:

• Insufficient tissue, i.e., at least one tissue biopsy to be obtained (Fresh Frozen or FFPE)

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort
Cohort A; 300 participants with early stage resectable I-IIIB NSCLC
Cohort B; 200 participants with unresectable late stage IIIB-IIIC or de novo metastatic (stage IV) NSCLC.
Cohort C; 50-100 participants with stage I-IV SCLC or pleural mesothelioma.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall Survival		5 years
Disease Free Survival	DFS; recurrence or death from any cause): Cohorts A & C	5 years
Progression Free Survival	PFS; first disease progression or death from any cause): Cohorts B & C	5 years

Collaborators and Investigators

• Sponsor: University College, London
• Collaborators: Cancer Research UK

Study record dates

Study Major Dates

• Study Start (Actual): December 4, 2023
• Primary Completion (Estimated): December 1, 2030
• Study Completion (Estimated): June 1, 2034

Study Registration Dates

• First Submitted: November 16, 2022
• First Submitted That Met QC Criteria: November 16, 2022
• First Posted (Actual): November 28, 2022

Study Record Updates

• Last Update Posted (Actual): April 2, 2025
• Last Update Submitted That Met QC Criteria: March 27, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms by Site; Neoplasms; Respiratory Tract Diseases; Neoplasms by Histologic Type; Lung Diseases; Neoplasms, Glandular and Epithelial; Respiratory Tract Neoplasms; Thoracic Neoplasms; Adenoma; Neoplasms, Mesothelial; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Mesothelioma; Carcinoma, Non-Small-Cell Lung; Small Cell Lung Carcinoma
• Other Study ID Numbers: UCL - 151927

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No