The Effect of a Peat and Apple Extract on Muscle ATP and Exercise Performance (APEX)

March 21, 2023 updated by: University of Exeter
A study to test the hypothesis that a combined peat and apple extract will increase blood and muscle ATP, which will increase cycling performance

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

10

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
    • Devon
      • Exeter, Devon, United Kingdom, EX1 2LU
        • University of Exeter

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Age 18 - 40
  • Healthy
  • Recreationally active (i.e. Participants will be deemed as too trained if they are defined as participating in structured resistance exercise 3 or more times per week for >6 months or participating in structured endurance exercise for >6h per week for >6 months. Participants will be defined as too sedentary if they do not exceed the governments guidelines of 150 / 75 min per week of light / heavy exercise.)

Exclusion Criteria:

  • Allergy to Lidocaine
  • Any diagnosed metabolic health condition
  • Pregnant
  • Non-habitual caffeine intake
  • Smoker
  • Diagnosed Cardiovascular disease
  • Beta-Blockers
  • Recent history of musculoskeletal injury

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: ElevATP supplement
Dietary supplement: ElevATP supplement
ElevATP supplement containing apple and ancient peat extract
Placebo Comparator: Maltodextrin placebo
Dietary supplement: Placebo
Maltodextrin placebo

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Muscle ATP concentration
Time Frame: 4 hours
Concentration of ATP in skeletal muscle tissue (mmol/kg dry weight)
4 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Total work performed during exercise
Time Frame: 2 hours
Work performed during glycogen depleting exercise on a cycle ergometer (J)
2 hours
Blood ATP concentration
Time Frame: 4 hours
Concentration of ATP in blood (mmol/L)
4 hours
Substrate oxidation
Time Frame: 1 hour
Substrate oxidation over 1 h steady state cycle (g/min)
1 hour
Blood glucose concentration
Time Frame: 4 hours
Concentration of glucose in blood (mmol/L)
4 hours
Blood lactate concentration
Time Frame: 4 hours
Concentration of lactate in blood (mmol/L)
4 hours
Muscle glycogen
Time Frame: 4 hours
Muscle glycogen concentration in skeletal muscle tissue (mmol/kg dry weight)
4 hours
Muscle ADP concentration
Time Frame: 4 hours (mmol/kg dry weight)
Concentration of muscle metabolites
4 hours (mmol/kg dry weight)
Muscle ATP concentration
Time Frame: 4 hours (mmol/kg dry weight)
Concentration of muscle metabolites
4 hours (mmol/kg dry weight)
Muscle creatine concentration
Time Frame: 4 hours (mmol/kg dry weight)
Concentration of muscle metabolites
4 hours (mmol/kg dry weight)
Muscle phosphocreatine concentration
Time Frame: 4 hours (mmol/kg dry weight)
Concentration of muscle metabolites
4 hours (mmol/kg dry weight)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Exeter

Collaborators

VDF FutureCeuticals Inc.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 17, 2022

Primary Completion (Actual)

February 15, 2023

Study Completion (Actual)

February 15, 2023

Study Registration Dates

First Submitted

November 1, 2022

First Submitted That Met QC Criteria

November 30, 2022

First Posted (Actual)

December 7, 2022

Study Record Updates

Last Update Posted (Actual)

March 22, 2023

Last Update Submitted That Met QC Criteria

March 21, 2023

Last Verified

March 1, 2023

More Information

Terms related to this study

Other Study ID Numbers

  • 516252

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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