Comparison of Perioperative Analgesic Efficacy of Femoral Nerve Block, Adductor Canal Block and 4in1 Block

June 30, 2025 updated by: Funda Atar, Diskapi Yildirim Beyazit Education and Research Hospital

Comparison of Perioperative Analgesic Efficacy in Patients Who Had Femoral Nerve Block, Adductor Canal Block and 4in1 Block Applied in Knee Surgery

Central neuraxial and regional anesthesia and analgesia techniques significantly reduce perioperative morbidity and mortality in the knee and below-knee surgeries.Nerve blocks appear to have better analgesic efficacy compared to placebo or patient-controlled analgesia (PCA). In addition, opioid-related side effects such as postoperative nausea, vomiting, pruritus, sedation, and respiratory depression are less. Therefore, interest in regional blocks such as femoral, sciatic, adductor, combined femoral, and sciatic is increasing. The knee joint is innervated by various nerves (genicular nerves) from the femoral, obturator, and sciatic nerves, and a comprehensive but simple technique is needed for postoperative analgesia. Complete and comprehensive postoperative analgesia was possible with this block, a simple single injection technique. The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block, and 4in1 block in patients who will undergo knee surgery.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Ankara, Turkey, 06000
        • University of Medical Science, Yıldırım Beyazıt Training and Research Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 99 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patients between the ages of >18
  • undergone knee surgery
  • American Society of Anesthesiologists (ASA) classification I-III group.

Exclusion Criteria:

  • Patients who do not want to participate in the study coagulopathy peripheral neuropathy local anesthetic drug allergy chronic opioid users anticoagulant users pregnant patients

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: femoral nerve block
To evaluate the intraoperative analgesia effectiveness of femoral nerve block in patients who will have knee surgery.
Other: femoral nerve block
To evaluate the intraoperative analgesia effectiveness of femoral block in patients who will have knee surgery.
Experimental: adductor canal block
To evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery.
Other: adductor canal block
To evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery.
Experimental: 4in1 block
To evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery.
Other: 4in1 block
To evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
intraoperative analgesia efficacy
Time Frame: perioperative period
The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.
perioperative period

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
postoperative analgesia efficacy
Time Frame: perioperative period
The aim of our study is to evaluate the postoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.
perioperative period

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Diskapi Yildirim Beyazit Education and Research Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2022

Primary Completion (Actual)

June 20, 2025

Study Completion (Actual)

June 30, 2025

Study Registration Dates

First Submitted

November 23, 2022

First Submitted That Met QC Criteria

December 1, 2022

First Posted (Actual)

December 8, 2022

Study Record Updates

Last Update Posted (Actual)

July 3, 2025

Last Update Submitted That Met QC Criteria

June 30, 2025

Last Verified

June 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 06/06/2022 139/13

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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