Cerebrospinal Fluid Gravity Correlation Analysis

Correlation Between Blood Biochemical Indicators and Cerebrospinal Fluid Gravity in Aged Patients

The purpose of this study was to measure cerebrospinal fluid density in aged patients and to see if there was a correlation between these factors and cerebrospinal fluid density by using the electronic medical record system to understand the patient's gender, blood glucose, blood biochemical electrolytes and blood levels.

Study Overview

• Status: Not yet recruiting
• Conditions: Specific Gravity; Cerebrospinal Fluid
• Intervention / Treatment: Diagnostic test: Cerebrospinal fluid densitometry; Diagnostic test: blood routine examination; Diagnostic test: Blood electrolyte examination

Detailed Description

Hip joint injury is one of the common injuries in the elderly, and hip arthroplasty is a treatment method that allows patients to get out of bed and return to social life as soon as possible. Currently, the common position for hip arthroplasty is the lateral position; and combined spinal and epidural anesthesia or subarachnoid anesthesia is also the common anesthesia method for hip arthroplasty. In the lateral position, the patient's affected limb is often on top and the healthy limb is on the bottom; the healthy side position is also the usual position for hip arthroplasty. In this position, it may be optimal to use a lighter specific gravity local anesthetic drug because it tends to anesthetize only the upper affected limb and does not require a return to the supine position after anesthesia due to changes in the plane of block, minimizing pain and hemodynamic fluctuations during anesthesia and position changes.

Currently, light specific gravity is more of a concept. Because in the available data, only the range of cerebrospinal fluid density of ordinary healthy adults is available, there is little literature and data to describe and analyze what the cerebrospinal fluid density of elderly patients actually is. Therefore, when we administer subarachnoid anesthesia to elderly patients, we cannot determine whether the dispensed local anesthetic drug is a light specific gravity.

In this study, we intend to collect cerebrospinal fluid from elderly patients who underwent hip arthroplasty under combined lumbar and rigid anesthesia or subarachnoid anesthesia, and measure the cerebrospinal fluid density in elderly patients, and observe whether there is a correlation between the above factors and cerebrospinal fluid density through the electronic medical record system to understand the patient's gender, blood glucose, blood biochemical electrolytes and routine blood levels; thus, we can better guide the use of lighter specific gravity drugs in clinical practice.

• Study Type: Observational
• Enrollment (Anticipated): 80

Contacts and Locations

• Study Contact: Name: Zhiming Zhang; Phone Number: +8613875555649; Email: otc0735@163.com
• Study Contact Backup: Name: Yuan Qin; Phone Number: 13657381087; Email: uscqinyuan@163.com

Study Locations

• China
  • Hunan
    • Chenzhou, Hunan, China, 423000
      • Zhiming Zhang
      • Contact: Zhiming Zhang, M.D.; Phone Number: +8613875555649; Email: otc0735@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Selected aged patients who had hip arthroplasty in our hospital between December 2022 and May 2023

Description

Inclusion Criteria:

• Receiving combined spinal and epidural anesthesia or subarachnoid anesthesia ASA Ⅰ or Ⅱ patients No significant neurological pathology No recent history of cerebral infarction No recent history of cerebral hemorrhage No central nervous system inflammation No spinal inflammatory disease No history of spinal surgery Patients who have given pre-operative informed written consent

Exclusion Criteria:

-

Study Plan

How is the study designed?

Design Details

• Observational Models: Ecologic or Community
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group A; Patients were aged 60-69 years	Diagnostic test: Cerebrospinal fluid densitometry; After obtaining the patient's cerebrospinal fluid specimen, the actual mass of the cerebrospinal fluid was measured by pipetting 1000 μL of cerebrospinal fluid specimen on an analytical balance using a pipette gun, and all specimens were measured three times and the average of the three times was taken as the final mass of 1000 μL of that specimen. After the mass measurement, the residual cerebrospinal fluid was disposed of as medical waste. The density of each specimen was obtained according to the density to mass conversion formula ρ=m/v.; Diagnostic test: blood routine examination; After obtaining the patient's blood specimens, they were sent to the laboratory for blood routine examination.; Diagnostic test: Blood electrolyte examination; After obtaining the patient's blood specimens, they were sent to the laboratory for blood electrolyte examination.
Group B; Patients were aged 70-79 years	Diagnostic test: Cerebrospinal fluid densitometry; After obtaining the patient's cerebrospinal fluid specimen, the actual mass of the cerebrospinal fluid was measured by pipetting 1000 μL of cerebrospinal fluid specimen on an analytical balance using a pipette gun, and all specimens were measured three times and the average of the three times was taken as the final mass of 1000 μL of that specimen. After the mass measurement, the residual cerebrospinal fluid was disposed of as medical waste. The density of each specimen was obtained according to the density to mass conversion formula ρ=m/v.; Diagnostic test: blood routine examination; After obtaining the patient's blood specimens, they were sent to the laboratory for blood routine examination.; Diagnostic test: Blood electrolyte examination; After obtaining the patient's blood specimens, they were sent to the laboratory for blood electrolyte examination.
Group C; Patients were aged 80-89 years	Diagnostic test: Cerebrospinal fluid densitometry; After obtaining the patient's cerebrospinal fluid specimen, the actual mass of the cerebrospinal fluid was measured by pipetting 1000 μL of cerebrospinal fluid specimen on an analytical balance using a pipette gun, and all specimens were measured three times and the average of the three times was taken as the final mass of 1000 μL of that specimen. After the mass measurement, the residual cerebrospinal fluid was disposed of as medical waste. The density of each specimen was obtained according to the density to mass conversion formula ρ=m/v.; Diagnostic test: blood routine examination; After obtaining the patient's blood specimens, they were sent to the laboratory for blood routine examination.; Diagnostic test: Blood electrolyte examination; After obtaining the patient's blood specimens, they were sent to the laboratory for blood electrolyte examination.
Group D; Patient age > 90 years	Diagnostic test: Cerebrospinal fluid densitometry; After obtaining the patient's cerebrospinal fluid specimen, the actual mass of the cerebrospinal fluid was measured by pipetting 1000 μL of cerebrospinal fluid specimen on an analytical balance using a pipette gun, and all specimens were measured three times and the average of the three times was taken as the final mass of 1000 μL of that specimen. After the mass measurement, the residual cerebrospinal fluid was disposed of as medical waste. The density of each specimen was obtained according to the density to mass conversion formula ρ=m/v.; Diagnostic test: blood routine examination; After obtaining the patient's blood specimens, they were sent to the laboratory for blood routine examination.; Diagnostic test: Blood electrolyte examination; After obtaining the patient's blood specimens, they were sent to the laboratory for blood electrolyte examination.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cerebrospinal fluid density	After obtaining the mass of cerebrospinal fluid, the density was calculated from ρ=m/v	baseline (before anesthesia)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood sugar	Plasma glucose level	baseline (before anesthesia)
Plasma K+ concentration	Plasma K+ concentration	baseline (before anesthesia)
Plasma Cl- concentration	Plasma Cl- concentration	baseline (before anesthesia)
WBC	Leukocyte concentration in blood	baseline (before anesthesia)
Neutrophil concentration in blood	Neutrophil concentration in blood	baseline (before anesthesia)
Lymphocyte concentration in blood	Lymphocyte concentration in blood	baseline (before anesthesia)
C-reactive protein (CRP)	C-reactive protein concentration in plasma	baseline (before anesthesia)

Collaborators and Investigators

• Sponsor: First People's Hospital of Chenzhou

Study record dates

Study Major Dates

• Study Start (Anticipated): December 1, 2022
• Primary Completion (Anticipated): May 31, 2023
• Study Completion (Anticipated): May 31, 2023

Study Registration Dates

• First Submitted: December 1, 2022
• First Submitted That Met QC Criteria: December 8, 2022
• First Posted (Estimate): December 9, 2022

Study Record Updates

• Last Update Posted (Estimate): December 9, 2022
• Last Update Submitted That Met QC Criteria: December 8, 2022
• Last Verified: November 1, 2022

More Information

Terms related to this study

• Keywords: Cerebrospinal fluid; Correlation Analysis; Lighter Specific Gravity
• Other Study ID Numbers: 202201

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No