- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05734482
Pharmacokinetic, Safety and Immunogenicity Study of CMAB015 and Cosentyx in Healthy Volunteers
April 9, 2024 updated by: Taizhou Mabtech Pharmaceutical Co.,Ltd
Phase I Comparison of Pharmacokinetics, Safety, and Immunogenicity of CMAB015 Injection and Cosentyx in a Randomized, Double-blind, Parallel Controlled, Single-dose Study in Healthy Chinese Male Subjects
This is a randomized, double-blinded, controlled Phase I study of CMAB015 administered by subcutaneous injection.
This study will characterize the pharmacokinetic, safety and immunogenicity of CMAB015 versus Cosentyx(Secukinumab ) in healthy male subjects after a single dose.
Study Overview
Detailed Description
This is a randomized, double-blind, parallel-controlled, single-dose phase I clinical study in healthy Chinese male subjects.
A total of 130 subjects were planned to be enrolled and randomly assigned to the test group or the control group in a 1:1 ratio.
Subjects in both groups received a single upper arm subcutaneous injection of CMAB015 or Cosentyx(Secukinumab) 150 mg, respectively.
Subjects in both groups were observed for 112 days after administration to evaluate similarities in pharmacokinetics, safety, and immunogenicity.
Study Type
Interventional
Enrollment (Actual)
130
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Anhui
-
Hefei, Anhui, China
- The Second Hospital of Anhui Medical University
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 45 years (Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- Healthy male volunteers, age ranged 18 to 45 years (both inclusive);
- Subjects with body weight of ≥50 kg and ≤ 75 kg and BMI ≥18 and <28 kg/m2 ;
- Subjects and their partners were willing to use medically approved contraceptive methods within 6 months of study administration, partners did not plan to become pregnant, subjects did not plan to donate sperm;
- The subjects have the ability to understand the full characteristics and objectives of the study, including the possible risks and side effects of the study; Moreover, the subjects can communicate well with researchers and complete the research according to the regulations;
- Subjects voluntarily sign ICF prior to the study.
Exclusion Criteria:
- After comprehensive examination (vital signs, physical examination, electrocardiogram, chest radiography, abdominal B-ultrasound, blood routine, urine routine, blood biochemistry, etc.), any examination item was judged abnormal by the investigator and had clinical significance;
- Patients with serious diseases such as cardiovascular system, endocrine system, nervous system, digestive system, respiratory system, genitourinary system, hematopoietic system, immune system, or any of the above diseases;
- Patients with currently active infected diseases;
- Subjects with past or current inflammatory bowel disease;
- History of malignant neoplasms within the last 5 years (other than completely resected basal cell or squamous cell carcinoma of the skin in situ);
- Any one of HBV surface antigen, HCV antibody, HIV antibody, treponema pallidum antibody positive;
- Subjects with T-SPOT test positive;
- Those who smoked more than 5 cigarettes per day in the 6 months before screening and did not cooperate with smoking bans during the study period;
- Alcoholics,or participants who consumed more than 14 units of alcohol per week (1 unit = 17.7mL ethanol, i.e., 1 unit = 357mL 5% beer or 43mL 40% liquor or 147mL 12% wine) during the preceding 3 months were screened,or who have positive result in blood-test of alcohol or not willing to ban alcohol;
- Drug abusers, or drug users in the 3 months prior to screening, or excessive daily consumption of tea, coffee and/or caffeinated beverages (more than 8 cups, 1 cup =250mL) in the 3 months prior to screening, or positive urine drug screening;
- Surgery within 4 weeks prior to screening; Or plan to have surgery during the study period;
- Use of any prescription drug, over-the-counter drug or health product within 4 weeks prior to screening, or prior use of such drug or health product within 5 half-lives, whichever is longer;
- Those who have used any biological agent, including live vaccine, in the 3 months prior to screening, or who plan to receive live vaccine during the study period;
- Anti-il-17 antibody active ingredient, excipients or latex allergy;
- Those with anti-IL-17 antibody and anti-drug antibody positive;
- Those who have been enrolled in other clinical studies or less than 3 months since the end of the most recent clinical study;
- Those who had lost blood or donated at least 400 mL in the 3 months prior to the trial, or had lost blood or donated at least 200 mL in the 1 month prior to screening, or planned to donate blood during the trial;
- Those who Can not tolerate venipunction, has a history of dizziness of needle and blood;
- Those who have special dietary requirements, or can not accept uniform diet;
- Other conditions considered inappropriate to be included in this study.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Biosimilar Product
CMAB015 150 mg Subcutaneous injection in upper arm
|
for subcutaneous injection only
|
Active Comparator: Reference Product
Cosentyx(Secukinumab ) 150 mg Subcutaneous injection in upper arm
|
for subcutaneous injection only
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Area Under the Plasma Concentration-time Curve From Zero (0) Hours Extrapolated to infinite time
Time Frame: up to 2688 hours
|
Area Under the Plasma Concentration-time Curve From Zero (0) Hours Extrapolated to infinite time After the Single injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Maximum Concentration of Secukinumab
Time Frame: up to 2688 hours
|
Maximum Concentration of Secukinumab After the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Time to Maximum Concentration of Secukinumab
Time Frame: up to 2688 hours
|
Time to Maximum Concentration of Secukinumab after the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Area Under the Plasma Concentration-time Curve From Zero (0) Hours to 2688 Hours
Time Frame: up to 2688 hours
|
Area Under the Plasma Concentration-time Curve From Zero (0) Hours to 2688 Hours After the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Half time
Time Frame: up to 2688 hours
|
Half-time after the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Clearance Rate
Time Frame: up to 2688 hours
|
Clearance Rate after the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Apparent Volume of Distribution
Time Frame: up to 2688 hours
|
Apparent Volume of Distribution after the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Terminal phase elimination rate constant
Time Frame: up to 2688 hours
|
Terminal phase elimination rate constant after the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
anti-drug antibodies(ADA)
Time Frame: up to 2688 hours
|
ADA Positive Rate after the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Neutralization antibodies(Nab)
Time Frame: up to 2688 hours
|
Neutralizing Antibody Positive Rate after the Single Injection of CMAB015/Cosentyx
|
up to 2688 hours
|
Percentage of participants with Adverse Events
Time Frame: up to 2688 hours
|
Total Frequency of Adverse Events/Serious Adverse Events Within the Whole Time of the Study
|
up to 2688 hours
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Hu Wei, Doctor, The Second Hospital of Anhui University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
February 15, 2023
Primary Completion (Actual)
July 3, 2023
Study Completion (Actual)
July 3, 2023
Study Registration Dates
First Submitted
January 29, 2023
First Submitted That Met QC Criteria
February 15, 2023
First Posted (Actual)
February 21, 2023
Study Record Updates
Last Update Posted (Actual)
April 10, 2024
Last Update Submitted That Met QC Criteria
April 9, 2024
Last Verified
April 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CMAB015-001
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Psoriasis
-
ProgenaBiomeRecruitingPsoriasis | Psoriasis Vulgaris | Psoriasis of Scalp | Psoriatic Plaque | Psoriasis Universalis | Psoriasis Face | Psoriasis Nail | Psoriasis Diffusa | Psoriasis Punctata | Psoriasis Palmaris | Psoriasis Circinata | Psoriasis Annularis | Psoriasis Genital | Psoriasis GeographicaUnited States
-
Clin4allRecruitingPsoriasis of Scalp | Psoriasis Nail | Psoriasis Palmaris | Psoriasis Genital | Psoriasis PlantarisFrance
-
Innovaderm Research Inc.CompletedScalp Psoriasis | Pustular Palmo-plantar Psoriasis | Non-pustular Palmo-plantar Psoriasis | Elbow Psoriasis | Lower Leg PsoriasisCanada
-
Centre of Evidence of the French Society of DermatologyRecruitingPsoriasis | Psoriasis Vulgaris | Psoriasis of Scalp | Psoriatic Plaque | Psoriasis Universalis | Psoriasis Palmaris | Psoriatic Erythroderma | Psoriatic Nail | Psoriasis Guttate | Psoriasis Inverse | Psoriasis PustularFrance
-
UCB Biopharma S.P.R.L.CompletedModerate to Severe Psoriasis | Generalized Pustular Psoriasis and Erythrodermic PsoriasisJapan
-
AmgenCompletedPsoriasis-Type Psoriasis | Plaque-Type PsoriasisUnited States
-
Janssen Pharmaceutical K.K.RecruitingGeneralized Pustular Psoriasis | Erythrodermic PsoriasisJapan
-
Eli Lilly and CompanyCompletedGeneralized Pustular Psoriasis | Erythrodermic PsoriasisJapan
-
TakedaRecruitingGeneralized Pustular Psoriasis | Erythrodermic PsoriasisJapan
-
Shanghai Huaota Biopharmaceutical Co., Ltd.RecruitingGeneralized Pustular Psoriasis (GPP)China
Clinical Trials on Secukinumab
-
Novartis PharmaceuticalsRecruiting
-
Technical University of MunichNovartisCompletedPyoderma GangrenosumGermany
-
Novartis PharmaceuticalsCompletedPlaque PsoriasisThailand
-
Novartis PharmaceuticalsCompletedPlaque PsoriasisUnited States
-
University of Erlangen-Nürnberg Medical SchoolActive, not recruiting
-
Novartis PharmaceuticalsCompletedPsoriatic Arthritis | Axial SpondyloarthritisSpain
-
Novartis PharmaceuticalsCompletedPsoriasisUnited States
-
Saakshi KhattriCompleted
-
Novartis PharmaceuticalsTerminatedLupus NephritisChina, Croatia, Czechia, Russian Federation, Turkey, Australia, Spain, Thailand, Argentina, United States, Denmark, Greece, Romania, Germany, Korea, Republic of, India, Brazil, Japan, Peru, Portugal, Italy, Taiwan, Vietnam, Norway, Colo... and more