Assessment Of Different Scores In Predicting Outcome In AECOPD Patients In Emergency Department

Assessment Of Different Scores In Predicting Outcome In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease Patients In Emergency Department

evaluate the value of different scores in predicting hospital mortality and Need for MV In patients presented to ED with AECOPD.

Study Overview

• Status: Not yet recruiting
• Conditions: Chronic Obstructive Pulmonary Disease

Detailed Description

Chronic obstructive pulmonary disease (COPD) is one of the top three causes of death worldwide, and 90% of deaths occur in low- and middle-income countries.

Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is defined as an acute change in patient's dyspnea, cough, or sputum beyond normal variability that is sufficient to warrant a change in therapy. AECOPD has a negative effect on the quality of life, admission and readmission rates, and disease progression.

For these reasons, appropriate management of acute exacerbations is recommended by national and international organizations.

Identifying high-risk dying patients on hospital admission helps in triaging them to the required level of care.

The use of early warning scores in follow-up is recommended for the early detection of critically ill patients and the prediction of clinical deterioration. CURB65, BAP65, qSOFA , DECAF and NEWS, which mainly involve mental status, respiratory rate, oxygen saturations, pulse, blood pressure, age, BUN level, etc., can be used to predict AECOPD-associated mortality in ED given the simple structure and data availability.

• Study Type: Observational
• Enrollment (Anticipated): 139

Contacts and Locations

• Study Contact: Name: mohamed mo saleh, bachelor; Phone Number: 01128534859; Email: drmohamed33333@gmail.com
• Study Contact Backup: Name: maha mo sayed, MD; Phone Number: 01009656205; Email: mahaelkholy@yahoo.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All patient presented to ED with acute exacerbation of COPD no gender discrimination from 18 years to unlimit age

Description

Inclusion Criteria:

• All patient presented to ED with acute exacerbation of COPD.

Exclusion Criteria:

• Patient presented with acute insult affecting other system.
• Patient transferred to other centers.
• Inadequate data.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evaluate the value of different scores in predicting hospital mortality	Assessment Of Different Scores In Predicting Outcome In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease Patients In Emergency Department as DECAF(dyspnea grade V according to eMRCD,esinopenia<0.05x10*9/L,consolidation,acidemia<7.30,atrial fibrillation) 1=mild,2_3=moderate,4_5=severe can be used to predict AECOPD-associated mortality in ED given the simple structure and data availability.	one year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Value of these scores in predicting need for MV.	Value of these scores in predicting need for MV in AECOPD patient in ER	one year

Collaborators and Investigators

• Sponsor: Assiut University
• Investigators: Study Director: reham mo abdelmonem, MD, Assiut Uneversity

Publications and helpful links

General Publications

• Redfern OC, Smith GB, Prytherch DR, Meredith P, Inada-Kim M, Schmidt PE. A Comparison of the Quick Sequential (Sepsis-Related) Organ Failure Assessment Score and the National Early Warning Score in Non-ICU Patients With/Without Infection. Crit Care Med. 2018 Dec;46(12):1923-1933. doi: 10.1097/CCM.0000000000003359.

Study record dates

Study Major Dates

• Study Start (Anticipated): May 3, 2023
• Primary Completion (Anticipated): January 3, 2024
• Study Completion (Anticipated): December 3, 2024

Study Registration Dates

• First Submitted: November 23, 2022
• First Submitted That Met QC Criteria: March 30, 2023
• First Posted (Actual): March 31, 2023

Study Record Updates

• Last Update Posted (Actual): March 31, 2023
• Last Update Submitted That Met QC Criteria: March 30, 2023
• Last Verified: March 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Respiratory Tract Diseases; Disease Attributes; Emergencies; Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
• Other Study ID Numbers: different scores in AECOPD

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: sharing the result of the study after completion

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No