The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh

The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh Extraction Sockets; Randomized Controlled Clinical Trial.

The study will be conducted on 30 patients with split mouth design patients will be divided into curcumin and PRF groups patients will have bilateral tooth extraction one side will receive curcumin/PRF and the other side will be control soft tissue healing and bone quality will be evaluated post-operative

Study Overview

• Status: Completed
• Conditions: Tooth Extraction Status Nos; Tooth Fracture
• Intervention / Treatment: Other: extraction socket; Biological: PRF; Biological: Curcuma Longa gel

Detailed Description

30 Patients will be collected from the outpatient clinic of the Department of Oral &Maxillofacial surgery, Faculty of Dentistry, MSA University, Cairo, Egypt

Eligibility criteria:

Inclusion Criteria for participants:

1. Patients with bilateral badly decayed mandibular posterior tooth that need extraction.
2. Patients free from any systemic disease
3. Patients who approved to be included in the trial and signed the informed consent.
4. Patients with no signs or symptoms of acute periapical\ periodontal infection.
5. Adults aged between 18-50 years old.

Exclusion criteria for participants:

1. Patients who are allergic to Curcumin
2. Smoker patient
3. Patients receiving chemotherapy or radiotherapy.
4. Patients who refused to be included in the trial.

Interventions:

1. Diagnosis

   • All patients will be diagnosed and selected according to inclusion and exclusion criteria.
   • Comprehensive clinical examination and understanding of patient's chief complains and needs will be done.
   • Standard preoperative intra-oral photographs (occlusal and lateral)
   • (Pre-operative orthopantogram* will be taken to ensure absence of any periapical infection)

2. Intra-operative procedures:

   Local anesthesia* will be injected intraoral around selected teeth. Patients will rinse by antiseptic mouthwash** 30 seconds before extraction. Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage.

   The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group.

   After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture***

3. Postoperative treatment Analgesics **** every 6 hours for 3 days
4. Concomitant care None needed.

5. Follow up & Evaluation.

   • The extraction site will be inspected clinically after 3 days for signs of infection.
   • Soft tissue healing and pain score will be assessed after 7, 14, and 21 days.
   • 3 months post-operatively, each patient will undergo radiographic assessment by using Cone Beam Computed Tomography****** (CBCT) to evaluate bone healing and bone density.

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Phase 1

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt, 12855
    • Rania Farouk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• 1. Patients with bilateral badly decayed mandibular posterior tooth that need extraction.

  2. Patients free from any systemic disease 3. Patients who approved to be included in the trial and signed the informed consent.

  4. Patients with no signs or symptoms of acute periapical\ periodontal infection.

  5. Adults aged between 18-50 years old.

Exclusion Criteria:

• 1. Patients who are allergic to Curcumin 2. Smoker patient 3. Patients receiving chemotherapy or radiotherapy. 4. Patients who refused to be included in the trial.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Control; extraction socket .	Other: extraction socket; extraction socket
Active Comparator: PRF Group; extraction socket and PRF	Other: extraction socket; extraction socket; Biological: PRF; Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage. The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group. After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture
Active Comparator: Curcuma Longa Group; Extraction Socket and Curcuma Longa	Other: extraction socket; extraction socket; Biological: Curcuma Longa gel; Curcuma Longa gel

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Soft tissue healing	Healing index (change is being assessed)	21 days after surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Bone Density	CBCT (change is being assessed)	3 months after surgery

Collaborators and Investigators

• Sponsor: Rania Farouk Mohamed Abdulmaguid

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2024
• Primary Completion (Actual): February 1, 2026
• Study Completion (Actual): March 1, 2026

Study Registration Dates

• First Submitted: March 19, 2023
• First Submitted That Met QC Criteria: April 17, 2023
• First Posted (Actual): April 18, 2023

Study Record Updates

• Last Update Posted (Actual): March 27, 2026
• Last Update Submitted That Met QC Criteria: March 23, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Stomatognathic Diseases; Wounds and Injuries; Tooth Diseases; Tooth Injuries; Tooth Fractures; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Protective Agents; Antioxidants; Turmeric extract
• Other Study ID Numbers: REC-D652-3

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No