Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by EIT in Patients With ARDS

Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrome

Electrical impedance tomography was used to monitor changes in pulmonary perfusion distribution and V/Q ratio before and after iNO in patients with acute respiratory distress syndrome to investigate the factors predicting iNO reactivity and the physiological mechanism underlying changes in oxygenation.

Study Overview

• Status: Recruiting
• Conditions: Critical Illness

• Study Type: Observational
• Enrollment (Anticipated): 30

Contacts and Locations

• Study Contact: Name: Xiaojing Zou, prof.; Phone Number: +862785351606; Email: 249126734@qq.com

Study Locations

• China
  • Hubei
    • Wuhan, Hubei, China, 430000
      • Recruiting
      • Hongling Zhang
      • Contact: Hongling Zhang, master; Phone Number: 027-85351607 +862785726375; Email: 81243895@qq.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients with ARDS

Description

Inclusion Criteria:

1. Patients aged ≥ 18 years;
2. Patients are intubated and mechanically ventilated.

Exclusion Criteria:

1. EIT contraindications such as chest wound dressing, pacemaker installation, defibrillator, etc;
2. With a history of cerebral hemorrhage in the past half year, as well as bleeding in any site of the body;
3. Pneumothorax;
4. Medium or massive pleural effusion;
5. Refractory shock;
6. Pregnant
7. With chronic kidney disease
8. Atrial fibrillation or other malignant arrhythmia leads to a decrease in cardiac output;
9. Failure to sign informed consent

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Lung ventilation/perfusion ration	Lung ventilation/perfusion ration after iNO assessed by EIT	3 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Lung perfusion distribution	Lung ventilation/perfusion ration after iNO assessed by EIT	30minutes and 3 hours
Shunting	Lung shunting% after iNO assessed by EIT	30minutes and 3 hours
Dead space	Lung dead space after iNO assessed by EIT	30minutes and 3 hours
Oxygenation index	Oxygenation index= arterial partial pressure of oxygen/fraction of inspired oxygen	30minutes and 3 hours
Arterial partial pressure of carbon dioxide (PaCO2)	PaCO2 is one of the key indicators of pulmonary ventilation which can be obtained from arterial blood gas analysis.	30minutes and 3 hours
Static respiratory compliance (Crs)	Crs=tidal volume/driving pressure	30minutes and 3 hours
Cardiac output	Cardiac output assessed by echocardiography	30minutes and 3 hours
Right ventricular function	Right ventricular function assessed by echocardiography	30minutes and 3 hours

Collaborators and Investigators

• Sponsor: Wuhan Union Hospital, China

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2023
• Primary Completion (Anticipated): May 1, 2025
• Study Completion (Anticipated): May 1, 2025

Study Registration Dates

• First Submitted: May 10, 2023
• First Submitted That Met QC Criteria: May 15, 2023
• First Posted (Actual): May 24, 2023

Study Record Updates

• Last Update Posted (Actual): May 24, 2023
• Last Update Submitted That Met QC Criteria: May 15, 2023
• Last Verified: May 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Critical Illness
• Other Study ID Numbers: INOEIT20230404

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No