Flexible Reaching Control in Parkinson Disease (REACH-PD)

June 8, 2023 updated by: Université Catholique de Louvain

Behavioural Study of Reaching Control in Healthy Volunteers and Volunteers With Parkinson Disease in Dynamical Context

Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Belgium
      • Louvain-la-Neuve, Belgium, 1348
        • Recruiting
        • Université Catholique de Louvain
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

The study will be based on two populations: on population of volunteers with Parkinson disease, and one population of age and sex matched healthy individuals.

Description

Inclusion Criteria:

  • Ability to perform the task (assessed during the experiment)

Exclusion Criteria:

  • Inability to perform the task (motor) or to understand the task requirements (cognitive)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Control
Healthy volunteers
Other: Reaching movements
Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display.
PD
Patients with Parkinson disease
Other: Reaching movements
Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display.
Other: Disease Assessment
Disease stage assessed by trained professionals

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Kinematics
Time Frame: Measured during the entire experiment (an average of 4.5 years)
Position of the handle as a function of time. Units are millimetres
Measured during the entire experiment (an average of 4.5 years)
Surface Electromyogram
Time Frame: Measured during the entire experiment (an average of 4.5 years)
Surface recordings of muscles activities from the main muscles involved in movement production. Units are volts
Measured during the entire experiment (an average of 4.5 years)
Applied forces
Time Frame: Measured during the entire experiment (an average of 4.5 years)
Forces applied by participants on the robotic handle. Units are Newtons
Measured during the entire experiment (an average of 4.5 years)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Université Catholique de Louvain

Investigators

  • Study Director: Frédéric Crevecoeur, PhD, Université Catholique de Louvain

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2023

Primary Completion (Estimated)

October 31, 2027

Study Completion (Estimated)

October 31, 2027

Study Registration Dates

First Submitted

May 25, 2023

First Submitted That Met QC Criteria

June 8, 2023

First Posted (Estimated)

June 16, 2023

Study Record Updates

Last Update Posted (Estimated)

June 16, 2023

Last Update Submitted That Met QC Criteria

June 8, 2023

Last Verified

June 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • REACH-PD

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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