Effects of Breaking Sitting on Human Behaviour and Metabolic Health

Effects of Breaking Prolonged Sitting on 24-h Human Behaviours, Self-feelings, Metabolic Health and Cognition in Healthy Adults

This study primarily aimed to investigate effects of breaking up prolonged sitting with intermittent brisk walking in healthy young individuals on (1) post-trial human behaviours including energy intake and physical activity under free-living conditions and (2) cognitive performance in a simulated workplace environment.

Study Overview

• Status: Completed
• Conditions: Cognition; Energy Balance; Metabolic Health; Physical Activity Level
• Intervention / Treatment: Behavioral: Prolonged sitting; Behavioral: Breaking prolonged sitting

• Study Type: Interventional
• Enrollment (Actual): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • National Taiwan Normal University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Without current and any history of brain injury, neurological disorder, cardiometabolic related diseases, diabetes or cancers.
• Weight stable (not self-reported weight change ± 3 kg at least 3 months)
• Body mass index (BMI) ranging between 18.5 to 27 kg/m2
• Can walk safely on a treadmill

Exclusion Criteria:

• Smokers, post-menopausal female, and volunteers who used any medications that could influence metabolic and inflammatory responses.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Prolonged sitting; Participants sat on a chair during the trial in the laboratory.	Behavioral: Prolonged sitting; In the laboratory, after consuming 1st meal, participants sat on a chair for 180 min. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants sat on a chair for another 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.
Experimental: Breaking prolonged sitting; Participants walked regularly during the trial in the laboratory.	Behavioral: Breaking prolonged sitting; In the laboratory, after consuming 1st meal, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants continued 2 min of walking every 20 min for the following 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Physical activity level	Changes in physical activity level (steps) in the free-living conditions	480 minutes
Energy intake	Changes in energy intake (kcal) in the free-living conditions	480 minutes
Cognitive performance	Changes in cognitive performance (% changes in accuracy) including Task Switching and Flanker tasks	320 minutes
Cognitive function	Changes in cognitive performance (% changes in reaction time) Task Switching and Flanker tasks	320 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Postprandial glucose concentrations	Changes in postprandial finger pricking glucose concentrations	320 minutes
Blood pressure	Changes in systolic blood pressure and diastolic blood pressure	320 minutes
Visual analogue scale (VAS)	Changes in self-perceived sensations including appetite, energy and mood (score from 0-100)	320 minutes
Continuous glucose monitoring	Changes in different depots of adipose tissue interstitial glucose concentrations	320 minutes

Collaborators and Investigators

• Sponsor: National Taiwan Normal University
• Collaborators: Division of Endocrinology and Metabolism, Tri-Service General Hospital

Study record dates

Study Major Dates

• Study Start (Actual): December 20, 2019
• Primary Completion (Actual): September 29, 2020
• Study Completion (Actual): September 29, 2020

Study Registration Dates

• First Submitted: May 20, 2023
• First Submitted That Met QC Criteria: June 9, 2023
• First Posted (Actual): June 22, 2023

Study Record Updates

• Last Update Posted (Actual): June 22, 2023
• Last Update Submitted That Met QC Criteria: June 9, 2023
• Last Verified: June 1, 2023

More Information

Terms related to this study

• Keywords: Executive function; Energy balance; Eating behaviour; Spontaneous physical activity; Breaking up sitting
• Other Study ID Numbers: 2-108-05-151

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No