Sepsis in ICU:Causes and Outcomes in Diabetics and Non Diabetics

Sepsis in ICU: Causes and Outcomes in Diabetics and Non Diabetics in Assiut University Hospital

Identify prevalence of sepsis in ICU of Assiut university hospital 2.Clarify different causes of sepsis in patients admitted to ICU . 3.Compare causes and outcomes of sepsis between diabetics versus non diabetics .

4.Screening for the co1.mmonest organism causing sepsis in critically ill patients .

Study Overview

• Status: Not yet recruiting
• Conditions: Sepsis
• Intervention / Treatment: Other: PCR for legionella ,blood ,urine cultures and from catheters or source of infection

Detailed Description

Sepsis, is defined as an infection with organ dysfunction, There is wide variation in sepsis rates, causative microorganisms, and outcome in ICU patients around the world.

Many conservative estimates considered sepsis as a leading cause of mortality and critical illness worldwide .

sepsis epidemiology studies worldwide revealed a highly variable incidence of 13-300 per 100,000 inhabitants per year for severe sepsis and 11 per 100,000 inhabitants per year for septic shock .

Factors such as advancing age, immunosuppression and multidrug-resistant infection play a role in increasing incidence of sepsis during recent decades .

Patients who survive sepsis often have long-term physical, psychological, and cognitive disabilities with significant health and social implications.

Patients with diabetes mellitus have an increased risk of developing infections and sepsis and they constitute 20.1-22.7% of all sepsis patients.

The prevalence of diabetes mellitus in ICU patients is as high as 30%, And such patients are at increased risk of experiencing in-hospital Complications, compared to patients without diabetes.

Infective complications may be reduced with lower blood glucose concentrations Moreover, in critically ill patients without diabetes, Hyperglycemia is associated with increased mortality, risk of infection, Kidney injury and cardiovascular complications.

Moreover, diabetes is a major risk factor for both Acute Kidney Injury and sepsis.

Sepsis also is a major cause of Acute Kidney Injury, which develops in one-fourth of all patients with sepsis and half of patients with bacteraemia or shock .

Sepsis-related AKI is associated with high mortality rates of up to 70%.

• Study Type: Observational
• Enrollment (Estimated): 85

Contacts and Locations

• Study Contact: Name: Mai Ahmed fathi, Specialist; Phone Number: 01009490399; Email: doc.maiahmad89@gmail.com
• Study Contact Backup: Name: Hala khalafalla el sherif, Professor; Phone Number: 01120110000; Email: dr_hala_elshereef@yahoo.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

All patients admitted to ICU diagnosed as sepsis or septic shock even on admission or later on then subdivided into 2 groups 1_Hyperglycemic (diabetic and non diabetic) .2_Normoglycemic(diabetic and non diabetic)

Description

Inclusion Criteria:

• according to sofa criteria Suspected /documented infection+sofa score >_2 or +ve Q sofa defined as 2or more 1_ hypotesion SBP<90.2_altered mental status GCS<13 3_ Exclusion Criteria:tachypnea>22 or septic shock criteria
• previous history of pulmonary problem Previous history of cardiac disease Previous history of autoimmune disease

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Detect the most common organism causing sepsis in ICU	Applying culture and sensitivity test for patients developed sepsis on admission and follow up will direct us for appropriate treatment for all patients	20 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of sepsis in diabetics versus non diabetics in ICU.	Assess the effect of hyperglycemia on spsis outcomes.	15 days

Collaborators and Investigators

• Sponsor: Assiut University

Study record dates

Study Major Dates

• Study Start (Estimated): July 1, 2023
• Primary Completion (Estimated): July 1, 2024
• Study Completion (Estimated): August 1, 2024

Study Registration Dates

• First Submitted: June 13, 2023
• First Submitted That Met QC Criteria: June 13, 2023
• First Posted (Actual): June 22, 2023

Study Record Updates

• Last Update Posted (Actual): June 26, 2023
• Last Update Submitted That Met QC Criteria: June 22, 2023
• Last Verified: June 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Sepsis; Toxemia
• Other Study ID Numbers: Sepsis pts investigate causes

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No