Qualitative Evaluation of Change Processes in Multifamily Therapy for Adolescents With Anorexia Nervosa (QUALI-TMF-TCA)

Therapeutic Process at Work in Multiple Family Therapy Groups for Anorexia Nervosa During Adolescence. An Exploratory Study.

Anorexia nervosa is a characterised disorder which forms part of the wider spectrum of eating disorders. It is a common pathology, particularly in adolescence, with a complex, severe prognosis in both somatic and psychiatric terms, and significant psychosocial consequences, particularly for family relationships.

The treatment of anorexia requires a multidisciplinary team of specialists who can offer individual and family-based approaches. International recommendations highlight the encouraging results of family therapy in the treatment of anorexia nervosa in adolescence. Various types of family approach exist, including "Family Based Treatments", which are a specific but highly effective approach, particularly widespread in the United States. Multifamily therapy (MFT), which involves bringing several families together to address the problem of anorexia, has proved effective for several years now.

Since January 2019, multifamily therapy has been offered to adolescents aged 12 to 18 who are being followed at the Maison de Solenn-Maison des Adolescents at Cochin hospital, for anorexia nervosa, as well as their families.

Each group brings together 5 to 7 families and comprises 10 3-hour sessions, with 3 weeks between each session. 2 groups are offered per year. Multi-family therapy therefore involves 10 to 14 families per year. It complements the other approaches available in the department.

To be able to describe the therapeutic processes at work in multifamily groups in order to be able to better describe our therapeutic device and envisage possible modifications. These processes would be broken down into four areas: MFT and its effects on the anorexic symptom, MFT and its effects on the family, MFT as group therapy and ways of improving the MFT system.

Study Overview

• Status: Recruiting
• Conditions: Anorexia Nervosa
• Intervention / Treatment: Behavioral: Psychotherapy

Detailed Description

Anorexia nervosa is a characterised disorder which forms part of the wider spectrum of eating disorders. It is a common pathology, particularly in adolescence, with a complex, severe prognosis in both somatic and psychiatric terms, and significant psychosocial consequences, particularly for family relationships.

The treatment of anorexia requires a multidisciplinary team of specialists who can offer individual and family-based approaches. International recommendations highlight the encouraging results of family therapy in the treatment of anorexia nervosa. Various types of family approach exist, including "Family Based Treatments", which are a specific but highly effective approach, particularly widespread in the United States. Multifamily therapy (MFT), which involves bringing several families together to address the problem of anorexia, has proved effective for several years now.

Since January 2019, multifamily therapy has been offered to adolescents aged 12 to 18 who are being followed at the Maison de Solenn-Maison des Adolescents at Cochin Hospital for anorexia nervosa, as well as their families.

Each group brings together 5 to 7 families and comprises 10 3-hour sessions, with 3 weeks between each session. 2 groups are offered per year. Multi-family therapy therefore involves 10 to 14 families per year. It complements the other approaches available in the department.

Primary objective:

To be able to describe the therapeutic processes at work in these multifamily groups in order to be able to better describe our therapeutic device and envisage possible modifications. These processes would be broken down into four areas: MFT and its effects on the anorexic symptom, MFT and its effects on the family, MFT as a group therapy and ways of improving the MFT system.

Secondary objectives:

• MFT and its effect on the symptom: to better describe and analyse the processes at work in multifamily therapy that lead to symptomatic improvement in adolescents through the perception of the adolescent himself, his parents or his brothers and sisters.
• MFT and its effects on the family: to describe in detail the psychotherapeutic processes within the MFT system that are involved in changing family relationships.
• MFT and its effects as group therapy: The context of group therapy is often a powerful lever/motivator of change and the investigators are seeking to better describe and understand the mechanisms at play in the group and how this influences the family and the anorexic symptom.
• Areas for improvement in MFT: Our study also aims to determine, in the context of a multifamily group for anorexia nervosa, the therapeutic contexts (single-family, intragenerational, multigenerational) and therapeutic mediations most conducive to change, in order to improve our practice and therapeutic proposals.

The study is therefore being proposed to all the families who have taken part in the multifamily therapy for anorexia nervosa, i.e. the adolescents being followed, their parents and siblings.

The investigators propose to use a qualitative methodology aimed at collecting the experiences of patients suffering from anorexia nervosa, their parents and their siblings, using alternately, depending on the group, data collection by focus group or by individual semi-structured interview according to a semi-structured interview guide specifically designed by the research team. The data was collected 4 to 6 months after the tenth and final session of the multifamily group.

The theoretical framework is qualitative and no statistical comparison is expected.

The investigators chose to use Interpretative Phenomenological Analysis (IPA) to study the meaning that the subject constructs from lived experiences. IPA is a recognised method of content analysis, particularly in health psychology.

Approximately 3 months after the end of a multifamily group on anorexia nervosa, the investigators will contact the families by telephone or e-mail to invite the families to take part in research interviews which will take place 4 to 6 months after the tenth and last session of the multifamily group in which the family took part.

The investigators will arrange to meet the families in the department on the same day to carry out an information interview, collect non-oppositions, interviews to collect socio-demographic data and then individual semi-structured interviews or focus groups (depending on staff availability).

The qualitative analysis of our research concerns the thematic analysis of the participants' discourse (adolescent patients, parents and siblings of these adolescents), so the main evaluation criterion concerns the extraction of sufficiently rich material from the discourse to carry out this analysis.

• Study Type: Observational
• Enrollment (Estimated): 138

Contacts and Locations

• Study Contact: Name: Marie Benhammani-Godard; Phone Number: 0033158411190; Email: marie.godard@aphp.fr
• Study Contact Backup: Name: Salomé Grandclerc, MD; Phone Number: 0033158412426; Email: salome.grandclerc@aphp.fr

Study Locations

• France
  • Île-de-France Region
    • Paris, Île-de-France Region, France, 75014
      • Recruiting
      • University Hospital Cochin, Maison des Adolescents - Youth Department (Maison de Solenn)
      • Contact: Salomé Grandclerc, MD; Phone Number: 0033158412426; Email: salome.grandclerc@aphp.fr
      • Contact: Eloïse Hellier; Phone Number: 0033158412426; Email: eloise.hellier@aphp.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

The study is therefore being offered to all families who have taken part in multifamily therapy for anorexia nervosa, i.e. the adolescent patients being treated for anorexia nervosa, their parents and siblings.

These patients and their families come from the clinical population followed in our institution for anorexia nervosa: the Maison des Adolescents of the Cochin Hospital - Maison de Solenn (APHP, Paris). Participation in a multi-family group is complementary to the usual care provided in the department (psychiatric, pediatric and dietetic follow-up) and does not replace the usual individual care.

Description

Inclusion Criteria:

Families who have taken part in a multifamily group on anorexia nervosa, i.e. :

• Parents (or any adult identified as a referent by the teenager), teenagers and siblings (over 6 years old) who have taken part in multi-family therapy (people from the teenager's family who have not taken part in the group will not be included),
• Adolescents aged 12 to 20,
• Adolescents with anorexia nervosa according to DSM5 criteria,
• Adolescents treated at the Maison des Adolescents at Cochin Hospital,
• Non-opposition of adolescents, their parents and siblings.

It will be possible to include in the study a parent or sibling whose adolescent did not wish to take part in the research but who participated in the MFT group.

Exclusion Criteria:

• Contraindication to multifamily therapy (i.e. any family situation that makes it impossible to bring parents and children together in family therapy without changing the setting (parents stripped of parental authority, educational removal measure, mediated visits, etc.),
• Any patient whose main diagnosis is not anorexia nervosa according to DSM5 criteria.
• Patients with an autistic spectrum disorder, a chronic psychotic disorder or an intellectual disability as their primary or secondary diagnosis according to DSM 5.
• Participants under curatorship or guardianship
• Participants not covered by a Social Security scheme.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

Participants in a multifamily therapy group for adolescents, their parents and siblings; The study is therefore being proposed to all the families who have taken part in the multifamily therapy for anorexia nervosa, i.e. the adolescents being followed, their parents and siblings. The investigators propose to use a qualitative methodology aimed at collecting the experiences of patients suffering from anorexia nervosa, their parents and their siblings, using alternately, depending on the group, data collection by focus group or by individual semi-structured interview according to a semi-structured interview guide specifically designed by the research team. The data was collected 4 to 6 months after the tenth and final session of the multi-family group.

Behavioral: Psychotherapy; Multifamily therapy (MFT), which involves bringing several families together to address the problem of anorexia nervosa, has proved effective for several years now. Since January 2019, multifamily therapy has been offered to adolescents aged 12 to 18 who are being treated for anorexia nervosa at the Maison de Solenn-Maison des Adolescents at Cochin Hospital, and to their families. Each group brings together 5 to 7 families and comprises 10 3-hour sessions, with 3 weeks between each session. 2 groups are offered per year. Multifamily therapy therefore involves 10 to 14 families per year. It complements the other approaches available in the department.; Other Names: Multifamily Therapy for anorexia nervosa during adolescence

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Semi-structured qualitative interviews	Semi-structured individual or group (focus group) interviews following a pre-designed interview guide. The qualitative analysis of our research concerns the thematic analysis of the participants' discourse (adolescent patients, parents and siblings of these adolescents), so the main evaluation criterion concerns the extraction of sufficiently rich material from the discourse to carry out this analysis.	Day of inclusion

Collaborators and Investigators

• Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborators: URC Necker Cochin, France
• Investigators: Study Director: Marie-Rose MORO, MD, PhD, University Hospital Cochin, Maison des Adolescents - Youth Department, F-75014 Paris, France; Principal Investigator: Salomé Grandclerc, MD, University Hospital Cochin, Maison des Adolescents - Youth Department, F-75014 Paris, France

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2023
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): May 1, 2027

Study Registration Dates

• First Submitted: October 13, 2023
• First Submitted That Met QC Criteria: October 13, 2023
• First Posted (Actual): October 19, 2023

Study Record Updates

• Last Update Posted (Estimated): September 12, 2025
• Last Update Submitted That Met QC Criteria: September 5, 2025
• Last Verified: September 1, 2025

More Information

Terms related to this study

• Keywords: Adolescence; Group therapy; Qualitative study; Anorexia nervosa; Familial relationships; Multiple family therapy groups; Therapeutic process
• Additional Relevant MeSH Terms: Mental Disorders; Feeding and Eating Disorders; Anorexia Nervosa; Behavioral Disciplines and Activities; Socioenvironmental Therapy; Psychotherapy; Psychotherapy, Group
• Other Study ID Numbers: APHP230662; 2023-A00668-37 (Other Identifier: ANSM (France))

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No